DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vha100-5 and Atp6v0a2

DIOPT Version :9

Sequence 1:	NP_001260388.1	Gene:	Vha100-5 / 34587	FlyBaseID:	FBgn0032373	Length:	814	Species:	Drosophila melanogaster
Sequence 2:	NP_035726.2	Gene:	Atp6v0a2 / 21871	MGIID:	104855	Length:	856	Species:	Mus musculus

Alignment Length:	874	Identity:	375/874 - (42%)
Similarity:	543/874 - (62%)	Gaps:	81/874 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGDMFRSEKMALCQLFIQPEAAYASIAELGEKGCVQFRDLNEEVSAFQRKYVNEVRRCDDMERRL 65
            ||.:||||.|.|.|||:|...||..::.|||||.|||||||:.||:||||:|.||:||:::||.|
Mouse     1 MGSLFRSESMCLAQLFLQSGTAYECLSALGEKGLVQFRDLNQNVSSFQRKFVGEVKRCEELERIL 65

  Fly    66 RYVESEMKKDEVKLPVLRPEEEPIAPNPREIVDLEAQLEKTDNELREMSANGASLDANFRHMQEL 130
            .|:..|:.:.::.||  ..|..|.||..:.:::::.||:|.:.||||::.|...|..|...:.|.
Mouse    66 VYLVQEITRADIPLP--EGEASPPAPPLKHVLEMQEQLQKLEVELREVTKNKEKLRKNLLELVEY 128

  Fly   131 KYVLENTEGFFSDQEVINLDVNRKLDP--------EDPANLP-GAAQR--GQLAFVAGVIKLERF 184
            .::|..|:.|        |..|.:.:|        |:.:.|. ...||  .:|.||:|:|:..|.
Mouse   129 THMLRVTKTF--------LKRNVEFEPTYEEFPALENDSLLDYSCMQRLGAKLGFVSGLIQQGRV 185

  Fly   185 FSFERMLWRISRGNIFLRRADIDGLVADEETGRPVLKTVFVAFFQGEQLKQRIKKVCTGYHAAVY 249
            .:|||||||..:|...:..|::|..:.|.|||..:...||:..|.|||:..::||:|..||..:|
Mouse   186 EAFERMLWRACKGYTIVTYAELDECLEDPETGEVIKWYVFLISFWGEQIGHKVKKICDCYHCHIY 250

  Fly   250 PCPSSHAERKEMIKDVNVRLEDLKLVLSQSADHRSRVLNSASKHLPRWSIMVRKMKAIYHILNFF 314
            |.|::..||:|:.:.:|.|::||..||.::.|:..:||..|::.:....:.|||||||||:||..
Mouse   251 PYPNTAEERREIQEGLNTRIQDLYTVLHKTEDYLRQVLCKAAESVCSRVVQVRKMKAIYHMLNMC 315

  Fly   315 NPDVTGKCLIGEGWVPTNDISTVQDALARASKISESSIPAFMNVIETNEMPPTYTRTNKFTNGFQ 379
            :.|||.||||.|.|.|..|:..::.||...|:.|.::||:|||.|.|.|.|||..||||||.|||
Mouse   316 SFDVTNKCLIAEVWCPEVDLPGLRRALEEGSRESGATIPSFMNTIPTKETPPTLIRTNKFTEGFQ 380

  Fly   380 NLVDSYGMASYREVNPALYACITFPFLFAVMFGDLGHGLILLLFASWLIIKEK--QLSSIKEEIF 442
            |:||:||:.|||||||||:..|||||||||||||.|||.::.|||..|::.|.  :||. .:||.
Mouse   381 NIVDAYGVGSYREVNPALFTIITFPFLFAVMFGDFGHGFVMFLFALLLVLNENHPRLSQ-SQEIL 444

  Fly   443 NIFFGGRYIIFLMGIFSIYTGFIYNDVFSKSMNIFGSAWHMN--YTRDVVEDENLKYI-----TL 500
            .:||.||||:.|||:||:|||.||||.||||:|:|||.|:::  |:.....:|..|.:     |:
Mouse   445 RMFFDGRYILLLMGLFSVYTGLIYNDCFSKSVNLFGSGWNVSAMYSSSHSPEEQRKMVLWNDSTI 509

  Fly   501 RPNDT---------VYK-TYPFGMDPIWQLADNKIIFLNTFKMKLSIIVGVIHMIFGVSMSVVNF 555
            |.:.|         |:: .||||:||||.||.|::.|||:||||:|:|:|:.||.|||.:.:.|.
Mouse   510 RHSRTLQLDPNIPGVFRGPYPFGIDPIWNLATNRLTFLNSFKMKMSVILGIFHMTFGVVLGIFNH 574

  Fly   556 AYYKKYASIFLEFLPQVLFLLLLFGYMVFMMFFKWVVYNDTVEGPLSPACAPSILILFINMILQG 620
            .:::|..:::|..:|::||:|.:|||::||:.:||:.|:......     ||||||.||||.|..
Mouse   575 LHFRKKFNVYLVSVPEILFMLCIFGYLIFMIIYKWLAYSAETSRE-----APSILIEFINMFLFP 634

  Fly   621 SQDTPEPCKEFMFDGQKSIQQVFVVVAIICIPWMLLGKPLYIM-----------------IKRKT 668
            :..|     ..::.||..:|:|.|.:.::.:|.:.|||||:::                 :.||.
Mouse   635 TSKT-----HGLYPGQAHVQRVLVALTVLAVPVLFLGKPLFLLWLHNGRNCFGMSRSGYTLVRKD 694

  Fly   669 NGAP------------PPKPQSGGGEGHGEDDEMGEIFIHQAIHTIEYVLSTVSHTASYLRLWAL 721
            :...            ..:.:.|..|...|:...|||.:.||||:|||.|..:|:||||||||||
Mouse   695 SEEEVSLLGNQDIEEGNSRMEEGCREVTCEEFNFGEILMTQAIHSIEYCLGCISNTASYLRLWAL 759

  Fly   722 SLAHAQLSEVLWNMVFSMGFKYDSYIGGILIYVFFGAWALLTVGILVLIEGLSAFLHTLRLHWVE 786
            ||||||||:|||.|:..:|.:.|:..|.:|:......:|:||:.||:::||||||||.:||||||
Mouse   760 SLAHAQLSDVLWAMLMRVGLRVDTTYGVLLLLPVMAFFAVLTIFILLVMEGLSAFLHAIRLHWVE 824

  Fly   787 FMSKFYEGAGYAFEPFAFKTILD-VSEDD 814
            |.:|||.|||..|.||:|..:.. .|.||
Mouse   825 FQNKFYVGAGTKFVPFSFSLLSSKFSNDD 853

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vha100-5	NP_001260388.1	NtpI	5..805	CDD:224188	369/858 (43%)
Vha100-5	NP_001260388.1	V_ATPase_I	28..804	CDD:279793	357/834 (43%)
Atp6v0a2	NP_035726.2	NtpI	5..839	CDD:224188	367/854 (43%)
Atp6v0a2	NP_035726.2	V_ATPase_I	28..839	CDD:279793	355/831 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1269
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53812
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000328
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100301
Panther	1	1.100	-	-	O	PTHR11629
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X226
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.820