DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vha100-5 and unc-32

DIOPT Version :9

Sequence 1:	NP_001260388.1	Gene:	Vha100-5 / 34587	FlyBaseID:	FBgn0032373	Length:	814	Species:	Drosophila melanogaster
Sequence 2:	NP_001023017.1	Gene:	unc-32 / 176257	WormBaseID:	WBGene00006768	Length:	905	Species:	Caenorhabditis elegans

Alignment Length:	898	Identity:	436/898 - (48%)
Similarity:	574/898 - (63%)	Gaps:	93/898 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGD------------MFRSEKMALCQLFIQPEAAYASIAELGEKGCVQFRDLNEEVSAFQRKYVN 53
            |||            ::|||:|.|.||::|.:|:|..:|||||.|.|||||||.:||:|||||||
Worm     1 MGDYVTPGEEPPQPGIYRSEQMCLAQLYLQSDASYQCVAELGELGLVQFRDLNPDVSSFQRKYVN 65

  Fly    54 EVRRCDDMERRLRYVESEMKKDEVKLPVLRPEEEPIAPNPREIVDLEAQLEKTDNELREMSANGA 118
            ||||||:|||:|||:|.|:|||::  |:|...|.|.||.|||::||||..||.:|||||::.|..
Worm    66 EVRRCDEMERKLRYLEREIKKDQI--PMLDTGENPDAPLPREMIDLEATFEKLENELREVNKNEE 128

  Fly   119 SLDANFRHMQELKYVLENTEGFFSDQE-----VINLDVNRK-----------------LDPEDPA 161
            :|..||..:.|||::|..|:.||.:.:     ::.....|:                 :|.:..|
Worm   129 TLKKNFSELTELKHILRKTQTFFEEVDHDRWRILEGGSGRRGRSTEREETRPLIDIGDMDDDSAA 193

  Fly   162 NLPGAAQRGQLAFVAGVIKLERFFSFERMLWRISRGNIFLRRADIDGLVADEETGRPVLKTVFVA 226
            .:...|...:|.||||||:.||..:|||:|||..|||:|||.::||.::.|..||.||.|.||:.
Worm   194 RMSAQAAMLRLGFVAGVIQRERLPAFERLLWRACRGNVFLRTSEIDDVLNDTVTGDPVNKCVFII 258

  Fly   227 FFQGEQLKQRIKKVCTGYHAAVYPCPSSHAERKEMIKDVNVRLEDLKLVLSQSADHRSRVLNSAS 291
            ||||:.||.::||:|.|:.|.:||||.:..||:||...|..|:||||.||.|:.|||.|||.:||
Worm   259 FFQGDHLKTKVKKICEGFRATLYPCPDTPQERREMSIGVMTRIEDLKTVLGQTQDHRHRVLVAAS 323

  Fly   292 KHLPRWSIMVRKMKAIYHILNFFNPDVTGKCLIGEGWVPTNDISTVQDALARASKISESSIPAFM 356
            |::..|...|||:|:|||.||.||.|||.||||.|.|.|..::..::.||.|.:..|.|.:|:.:
Worm   324 KNVRMWLTKVRKIKSIYHTLNLFNIDVTQKCLIAEVWCPIAELDRIKMALKRGTDESGSQVPSIL 388

  Fly   357 NVIETNEMPPTYTRTNKFTNGFQNLVDSYGMASYREVNPALYACITFPFLFAVMFGDLGHGLILL 421
            |.:||||.||||.:|||||.||||:||:||:|:|||:|||.|..|:|||||||||||:|||.|:|
Worm   389 NRMETNEAPPTYNKTNKFTKGFQNIVDAYGIATYREINPAPYTMISFPFLFAVMFGDMGHGAIML 453

  Fly   422 LFASWLIIKEKQLSS--IKEEIFNIFFGGRYIIFLMGIFSIYTGFIYNDVFSKSMNIFGSAWHMN 484
            |.|.:.|:|||||.:  ||:|||..||||||:|||||.|||||||:||||||||:|.|||:|...
Worm   454 LAALFFILKEKQLEAARIKDEIFQTFFGGRYVIFLMGAFSIYTGFMYNDVFSKSINTFGSSWQNT 518

  Fly   485 YTRDVV----EDENLKYITL-RPNDTVY--KTYPFGMDPIWQLAD-NKIIFLNTFKMKLSIIVGV 541
            ....|:    :||......| .|.:|.:  ..||.|:||:|.||: ||:.|||:.|||:|::.|:
Worm   519 IPESVIDYYLDDEKRSESQLILPPETAFDGNPYPIGVDPVWNLAEGNKLSFLNSMKMKMSVLFGI 583

  Fly   542 IHMIFGVSMSVVNFAYYKKYASIFLEFLPQVLFLLLLFGYMVFMMFFKWVVY---NDTVEGPLSP 603
            ..|.|||.:|..||.|:|....|...|:||::||..:|.|:...:..||:.:   ..||.|...|
Worm   584 AQMTFGVLLSYQNFIYFKSDLDIKYMFIPQMIFLSSIFIYLCIQILSKWLFFGAVGGTVLGYKYP 648

  Fly   604 A--CAPSILILFINMILQGSQDT----------PEPCKEFMFDGQKSIQQVFVVVAIICIPWMLL 656
            .  ||||:||..|||.:..|::.          |:......:.||.:|:.:.||:|::.:|.||.
Worm   649 GSNCAPSLLIGLINMFMMKSRNAGFVDDSGETYPQCYLSTWYPGQATIEIILVVLALVQVPIMLF 713

  Fly   657 GKPLYIMIKRKTNG----------------------------AP--PPKPQSGGGEGHGEDD-EM 690
            .||.::..:.|...                            ||  .||| ||.|.|||:.. ||
Worm   714 AKPYFLYRRDKQQSRYSTLTAESNQHQSVRADINQDDAEVVHAPEQTPKP-SGHGHGHGDGPLEM 777

  Fly   691 GEIFIHQAIHTIEYVLSTVSHTASYLRLWALSLAHAQLSEVLWNMVFSMGFKYDSYIGGILIYVF 755
            |::.::|||||||:||..|||||||||||||||||||||:|||.|||...|..|.|.|.|..|:.
Worm   778 GDVMVYQAIHTIEFVLGCVSHTASYLRLWALSLAHAQLSDVLWTMVFRNAFVLDGYTGAIATYIL 842

  Fly   756 FGAWALLTVGILVLIEGLSAFLHTLRLHWVEFMSKFYEGAGYAFEPFAFKTIL 808
            |..:..|:|.||||:||||||||.||||||||.||||.|.||.|.||:|:.||
Worm   843 FFIFGSLSVFILVLMEGLSAFLHALRLHWVEFQSKFYGGLGYEFAPFSFEKIL 895

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vha100-5	NP_001260388.1	NtpI	5..805	CDD:224188	430/877 (49%)
Vha100-5	NP_001260388.1	V_ATPase_I	28..804	CDD:279793	419/853 (49%)
unc-32	NP_001023017.1	NtpI	40..892	CDD:224188	419/854 (49%)
unc-32	NP_001023017.1	V_ATPase_I	40..891	CDD:279793	419/853 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160160169
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S598
OMA	1	1.010	-	-		QHG53812
OrthoDB	1	1.010	-	-		D164762at33208
OrthoFinder	1	1.000	-	-		FOG0000328
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100301
Panther	1	1.100	-	-	O	PTHR11629
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X226
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.810