DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vha100-5 and vha-6

DIOPT Version :9

Sequence 1:	NP_001260388.1	Gene:	Vha100-5 / 34587	FlyBaseID:	FBgn0032373	Length:	814	Species:	Drosophila melanogaster
Sequence 2:	NP_496436.1	Gene:	vha-6 / 174743	WormBaseID:	WBGene00006915	Length:	865	Species:	Caenorhabditis elegans

Alignment Length:	892	Identity:	384/892 - (43%)
Similarity:	534/892 - (59%)	Gaps:	111/892 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGDMFRSEKMALCQLFIQPEAAYASIAELGEKGCVQFRDLNEEVSAFQRKYVNEVRRCDDMERRL 65
            ||.::|||.|.|||:|.|.|:||..:|||||.|..||.|||||.:|:.||:||||||||:|||::
Worm     1 MGSIYRSEHMKLCQIFFQSESAYQCVAELGELGMAQFIDLNEEQNAYTRKFVNEVRRCDEMERKI 65

  Fly    66 RYVESEMKKDEVKLPVLRPEEEPIAPNPREIVDLEAQLEKTDNELREMSANGASLDANFRHMQEL 130
            .:||.|:.||.|.:|..  :|...||.|:.:.::||.|||.:.||.:::.|...|..|...:.|:
Worm    66 NFVEDEITKDLVPIPDY--DEHIPAPQPKHMGEMEANLEKLEEELVQINKNCKVLKNNHVQLLEM 128

  Fly   131 KYVLENTEGFFSDQEVINLDVNRKLDP---EDPANLPGAAQRG---------------------Q 171
            |.|||:              |...|||   .:.|.....|.||                     :
Worm   129 KAVLEH--------------VTSLLDPHSKREAAMSISEAARGEAGPISFGMKDEFDKPVKDEKE 179

  Fly   172 LAFVAGVIKLERFFSFERMLWRISRGNIFLRRADID---GLVADEETGRPVLKTVFVAFFQGEQL 233
            |.||.||:|..:..:|||.|||:||..:|.:...|.   .|.::|...    |.||:.||.||||
Worm   180 LKFVTGVVKRSKAIAFERFLWRLSRAKVFAKFIQIQEQTELFSNEFED----KCVFILFFSGEQL 240

  Fly   234 KQRIKKVCTGYHAAVYPCPSSHAERKEMIKDVNVRLEDLKLVLSQSADHRSRVLNSASKHLPRWS 298
            :.::||:|.|:.|..|..|.:.|||.:::.::.|:..|:|.|:.::.|:||:.:::|:.:|.:|.
Worm   241 RAKVKKICDGFQAKCYTVPENPAERTKLLLNIKVQTTDMKAVIEKTLDYRSKCIHAAATNLRKWG 305

  Fly   299 IMVRKMKAIYHILNFFNPDVTGKCLIGEGWVPTNDISTVQDALARASKISESSIPAFMNVIETNE 363
            ||:.|:|:|:|.||.|:.|||.||||.|.|||..||..|:::|...:..|.|::||.:|.:||::
Worm   306 IMLLKLKSIFHTLNMFSVDVTQKCLIAECWVPEADIGQVKNSLHMGTIHSGSTVPAILNEMETDK 370

  Fly   364 MPPTYTRTNKFTNGFQNLVDSYGMASYREVNPALYACITFPFLFAVMFGDLGHGLILLLFASWLI 428
            .||||.:.||||.||||:||:||:|:|||||||.:..|:|||||||||||.|||:|:|:.||..:
Worm   371 YPPTYFKLNKFTQGFQNIVDAYGIANYREVNPAPWTIISFPFLFAVMFGDAGHGIIMLIAASAFV 435

  Fly   429 IKEKQLSS--IKEEIFNIFFGGRYIIFLMGIFSIYTGFIYNDVFSKSMNIFGSAWHMNYTRDVV- 490
            |.||:|.|  ||:||||.||||||::.|||:|:|||||||||.:|||:|||||:|...|.:.::
Worm   436 IFEKKLISMKIKDEIFNTFFGGRYVVLLMGMFAIYTGFIYNDFYSKSVNIFGSSWVNPYNQTLLA 500

  Fly   491 ------EDENLKYITLRPNDTV----YKTYPFGMDPIWQLADNKIIFLNTFKMKLSIIVGVIHMI 545
                  .|.|.......|.:..    |..||||:||:|.||.|::.|||..|||.||::|:..|.
Worm   501 NMDAQGADSNTDLSLTFPPEIAFNHDYGPYPFGVDPVWNLAINRLNFLNPMKMKTSILLGISQMA 565

  Fly   546 FGVSMSVVNFAYYKKYASIFLEFLPQVLFLLLLFGYMVFMMFFKWV---VYNDTVEGPLSPA--C 605
            ||:.:|::|....:....|...|:||.|||..:|.|:...:..||:   |....:.|.|.|.  |
Worm   566 FGIMLSLMNHIGNRSVVDIVFVFIPQCLFLGCIFVYLCLQVLMKWIFFYVKPAYIFGRLYPGSNC 630

  Fly   606 APSILILFINMILQGSQDT-------PEPCKEFM--------------------FDGQKSIQQVF 643
            |||:||..|||.:..|:|.       ....||::                    :..|..::.:.
Worm   631 APSLLIGLINMFMVKSRDASFAHDVGTAAGKEWVIVNGQNVTYTINDQCYLQQWYPNQSLVELIL 695

  Fly   644 VVVAIICIPWMLLGKPLYIMIKRKTNGAPPPKPQSGG---GEGHGEDD----EMGEIFIHQAIHT 701
            :::|::.:|.|||.||.||..:           .|.|   ..|||.|:    ..|:|.:||||||
Worm   696 LLIAVVSVPVMLLVKPFYIRWR-----------HSRGLHIDLGHGPDEHGEFNFGDIMVHQAIHT 749

  Fly   702 IEYVLSTVSHTASYLRLWALSLAHAQLSEVLWNMVFSMGFKYDSYIGGILIYV-FFGAWALLTVG 765
            ||:||..|||||||||||||||||||||:|||.||..|......:.|...|.: |:..:::|:|.
Worm   750 IEFVLGCVSHTASYLRLWALSLAHAQLSDVLWTMVLRMSLTMGGWGGSAAITILFYFIFSILSVC 814

  Fly   766 ILVLIEGLSAFLHTLRLHWVEFMSKFYEGAGYAFEPFAFKTILDVSE 812
            ||:|:||||||||.:|||||||.||||.|.|..||||.|..|:.|.|
Worm   815 ILILMEGLSAFLHAIRLHWVEFQSKFYGGTGIQFEPFCFTKIIRVYE 861

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vha100-5	NP_001260388.1	NtpI	5..805	CDD:224188	378/879 (43%)
Vha100-5	NP_001260388.1	V_ATPase_I	28..804	CDD:279793	365/855 (43%)
vha-6	NP_496436.1	NtpI	28..858	CDD:224188	367/860 (43%)
vha-6	NP_496436.1	V_ATPase_I	28..853	CDD:279793	365/855 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	151	1.000	Domainoid score	I2677
eggNOG	1	0.900	-	-		E1_COG1269
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53812
OrthoDB	1	1.010	-	-		D164762at33208
OrthoFinder	1	1.000	-	-		FOG0000328
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100301
Panther	1	1.100	-	-	O	PTHR11629
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X226
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.830