DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vha100-5 and Atp6v0a1

DIOPT Version :9

Sequence 1:	NP_001260388.1	Gene:	Vha100-5 / 34587	FlyBaseID:	FBgn0032373	Length:	814	Species:	Drosophila melanogaster
Sequence 2:	XP_006532112.1	Gene:	Atp6v0a1 / 11975	MGIID:	103286	Length:	870	Species:	Mus musculus

Alignment Length:	883	Identity:	431/883 - (48%)
Similarity:	587/883 - (66%)	Gaps:	82/883 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGDMFRSEKMALCQLFIQPEAAYASIAELGEKGCVQFRDLNEEVSAFQRKYVNEVRRCDDMERRL 65
            ||::||||:|.|.|||:|.||||..::||||.|.|||||||.:|:.||||:|||||||::|:|:|
Mouse     1 MGELFRSEEMTLAQLFLQSEAAYCCVSELGELGKVQFRDLNPDVNVFQRKFVNEVRRCEEMDRKL 65

  Fly    66 RYVESEMKKDEVKLPVLRPEEEPIAPNPREIVDLEAQLEKTDNELREMSANGASLDANFRHMQEL 130
            |:||.|::|  ..:|::...|.|..|.||:::||||..||.:|||:|::.|..:|..||..:.||
Mouse    66 RFVEKEIRK--ANIPIMDTGENPEVPFPRDMIDLEANFEKIENELKEINTNQEALKRNFLELTEL 128

  Fly   131 KYVLENTEGFFSDQEVINLDVNRKLDP---EDPANL--PGAAQRG---QLAFVAGVIKLERFFSF 187
            |::|..|:.||.:.|   |...:..||   |:.::|  |....||   :|.||||||..||..:|
Mouse   129 KFILRKTQQFFDEAE---LHHQQMADPDLLEESSSLLEPNEMGRGAPLRLGFVAGVINRERIPTF 190

  Fly   188 ERMLWRISRGNIFLRRADIDGLVADEETGRPVLKTVFVAFFQGEQLKQRIKKVCTGYHAAVYPCP 252
            ||||||:.|||:|||:|:|:..:.|..||..|.|:||:.||||:|||.|:||:|.|:.|::||||
Mouse   191 ERMLWRVCRGNVFLRQAEIENPLEDPVTGDYVHKSVFIIFFQGDQLKNRVKKICEGFRASLYPCP 255

  Fly   253 SSHAERKEMIKDVNVRLEDLKLVLSQSADHRSRVLNSASKHLPRWSIMVRKMKAIYHILNFFNPD 317
            .:..|||||...||.|::||::||:|:.|||.|||.:|:|::..|.|.|||||||||.||..|.|
Mouse   256 ETPQERKEMASGVNTRIDDLQMVLNQTEDHRQRVLQAAAKNIRVWFIKVRKMKAIYHTLNLCNID 320

  Fly   318 VTGKCLIGEGWVPTNDISTVQDALARASKISESSIPAFMNVIETNEMPPTYTRTNKFTNGFQNLV 382
            ||.||||.|.|.|..|:.::|.||.|.::.|.|::|:.:|.::||:.||||.:|||||:||||:|
Mouse   321 VTQKCLIAEVWCPVTDLDSIQFALRRGTEHSGSTVPSILNRMQTNQTPPTYNKTNKFTHGFQNIV 385

  Fly   383 DSYGMASYREVNPALYACITFPFLFAVMFGDLGHGLILLLFASWLIIKEKQLSSIK--EEIFNIF 445
            |:||:.:|||:|||.|..|||||||||||||.|||:::.|||.|::::|.::.|.|  .|:|::.
Mouse   386 DAYGIGTYREINPAPYTVITFPFLFAVMFGDFGHGILMTLFAVWMVLRESRILSQKHENEMFSMV 450

  Fly   446 FGGRYIIFLMGIFSIYTGFIYNDVFSKSMNIFGSAWHM-------NYTRDVVEDENLKYITLRPN 503
            |.|||||.|||:||||||.||||.||||:|||||:|.:       |:|.:.:...::..:.....
Mouse   451 FSGRYIILLMGLFSIYTGLIYNDCFSKSLNIFGSSWSVRPMFTQGNWTEETLLGSSVLQLNPAIP 515

  Fly   504 DTVYKTYPFGMDPIWQLADNKIIFLNTFKMKLSIIVGVIHMIFGVSMSVVNFAYYKKYASIFLEF 568
            ......||||:||||.:|.||:.|||:||||:|:|:|:|||:||||:|:.|..|:||..:|:..|
Mouse   516 GVFGGPYPFGIDPIWNIATNKLTFLNSFKMKMSVILGIIHMLFGVSLSLFNHIYFKKPLNIYFGF 580

  Fly   569 LPQVLFLLLLFGYMVFMMFFKWVVYNDTVEGPLSPACAPSILILFINMILQGSQDTPEPCKEFMF 633
            :|:::|:..||||:|.::|:||..|:     ..|...|||:||.||||.|   ...||.....::
Mouse   581 IPEIIFMSSLFGYLVILIFYKWTAYD-----AHSSRNAPSLLIHFINMFL---FSYPESGNAMLY 637

  Fly   634 DGQKSIQQVFVVVAIICIPWMLLGKPLYI----MIKRKTNGAP-----PPKPQSGG--------- 680
            .|||.||...:|||::|:|||||.|||.:    :.|:...|.|     .|.|...|
Mouse   638 SGQKGIQCFLIVVAMLCVPWMLLFKPLILRHQYLRKKHLEGQPVEAPVTPTPSQQGLEAAPAATG 702

  Fly   681 ---------GEG----------------HGEDDE---------MGEIFIHQAIHTIEYVLSTVSH 711
                     |.|                |.||.|         .|:..:|||||||||.|..:|:
Mouse   703 TLNFGGIRVGNGPTEEDAEIIQHDQLSTHSEDAEEPTEDEVFDFGDTMVHQAIHTIEYCLGCISN 767

  Fly   712 TASYLRLWALSLAHAQLSEVLWNMVFSMGFKYDSYIGGILIYVFFGAWALLTVGILVLIEGLSAF 776
            ||||||||||||||||||||||.||..:|....|..||:.::..|.|:|.|||.||:::||||||
Mouse   768 TASYLRLWALSLAHAQLSEVLWTMVIHIGLHVRSLAGGLGLFFIFAAFATLTVAILLIMEGLSAF 832

  Fly   777 LHTLRLHWVEFMSKFYEGAGYAFEPFAFKTILDVSEDD 814
            ||.||||||||.:|||.|.|:.|.||:|:.|.:...|:
Mouse   833 LHALRLHWVEFQNKFYTGTGFKFLPFSFEHIREGKFDE 870

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vha100-5	NP_001260388.1	NtpI	5..805	CDD:224188	426/868 (49%)
Vha100-5	NP_001260388.1	V_ATPase_I	28..804	CDD:279793	412/844 (49%)
Atp6v0a1	XP_006532112.1	V_ATPase_I	27..860	CDD:366676	412/845 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167838554
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1269
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S598
OMA	1	1.010	-	-		QHG53812
OrthoDB	1	1.010	-	-		D164762at33208
OrthoFinder	1	1.000	-	-		FOG0000328
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100301
Panther	1	1.100	-	-	O	PTHR11629
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X226
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.670