DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Vha100-5 and si:ch73-173p19.2

DIOPT Version :9

Sequence 1:	NP_001260388.1	Gene:	Vha100-5 / 34587	FlyBaseID:	FBgn0032373	Length:	814	Species:	Drosophila melanogaster
Sequence 2:	XP_021326052.1	Gene:	si:ch73-173p19.2 / 100332691	ZFINID:	ZDB-GENE-141212-282	Length:	831	Species:	Danio rerio

Alignment Length:	856	Identity:	377/856 - (44%)
Similarity:	550/856 - (64%)	Gaps:	70/856 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGDMFRSEKMALCQLFIQPEAAYASIAELGEKGCVQFRDLNEEVSAFQRKYVNEVRRCDDMERRL 65
            |..:||||:|.|.|||:|.|:|:..|.|||..|.|||:|||...:||||::|.||::|:.|||.|
Zfish     2 MSCLFRSEEMCLVQLFLQTESAHNCINELGHLGLVQFKDLNPCATAFQRRFVKEVKKCEQMERIL 66

  Fly    66 RYVESEMKKDEVKLPVLRPEEEPIAPNPREIVDLEAQLEKTDNELREMSANGASLDANFRHMQEL 130
            ||:|.||.|..:.:...:  |:.:.|..|::::||:..||.:.||||::.|..:|..|...:.::
Zfish    67 RYLEKEMVKSNIVITATK--EKEMVPCARDVLELESTFEKLEQELREINHNHDTLRQNLIELMDI 129

  Fly   131 KYVLENTEGFFSDQE----------------VINLDVNRKLDPEDPANLPGAAQRGQLAFVAGVI 179
            ..:|..||.||.:.|                .|:..:..:.:.....:.|     ..|.|:||||
Zfish   130 DSLLRMTEDFFEEAESLLTFSEASSYDSVSMTISSFITSRRNSSSSTSGP-----LHLGFIAGVI 189

  Fly   180 KLERFFSFERMLWRISRGNIFLRRADIDGLVADEETGRPVLKTVFVAFFQGEQLKQRIKKVCTGY 244
            |.|||.:||::|||:..||..||.|:|......|.....|.|..|:.|.||:.::::|:|||.|:
Zfish   190 KQERFPAFEKVLWRLFHGNFVLRHAEIQTTEELEAVRGAVKKDAFIIFVQGDHVREKIRKVCEGF 254

  Fly   245 HAAVYPCPSSHAERKEMIKDVNVRLEDLKLVLSQSADHRSRVLNSASKHLPRWSIMVRKMKAIYH 309
            .|::|.||.:..|||||...:..|:|||:|||.::.::|:.||:.|::|:..|...|:||||||:
Zfish   255 RASLYSCPKTLYERKEMSNSIMTRMEDLRLVLRRTEEYRAGVLSRAAEHVQEWGSKVKKMKAIYY 319

  Fly   310 ILNFFNPDVTGKCLIGEGWVPTNDISTVQDALARASKISESSIPAFMNVIETNEMPPTYTRTNKF 374
            .||..|.|:|.|.::.|.|.|.:|::.||:||.:.|:.|.||:...:|.|:|.:.|||:.|||.|
Zfish   320 TLNLCNIDITQKLIVAEIWCPVSDLTVVQNALIKGSEQSGSSVTPVLNRIQTKQTPPTFNRTNSF 384

  Fly   375 TNGFQNLVDSYGMASYREVNPALYACITFPFLFAVMFGDLGHGLILLLFASWLIIKEKQLSSIKE 439
            |.|||.::|:||:.:|:|:|||.|..|||||||||||||.||||::.||:.|||.:...:...|.
Zfish   385 TEGFQAIIDAYGVGTYQEINPAPYTIITFPFLFAVMFGDCGHGLLMALFSVWLITQADYIRKWKN 449

  Fly   440 EIFNIFFGGRYIIFLMGIFSIYTGFIYNDVFSKSMNIFGSAW--------HMNYTRDVVEDENLK 496
            |:.::..|||:||.|||:||||||.||||.||||.|||||:|        |.::..:.:.|.:
Zfish   450 ELTDVLVGGRFIILLMGLFSIYTGLIYNDCFSKSFNIFGSSWCVRPMFHPHGSWQNETLHDHH-- 512

  Fly   497 YITLRP-NDTVYKTYP--FGMDPIWQLADNKIIFLNTFKMKLSIIVGVIHMIFGVSMSVVNFAYY 558
            ::.|.| ...|:..:|  ||:||||.:|.||:.|||:||||:|:|:||.||:|||::|:|||.::
Zfish   513 HLQLNPFVPGVFSGHPYVFGIDPIWNIASNKLSFLNSFKMKMSVILGVAHMLFGVTLSLVNFLHF 577

  Fly   559 KKYASIFLEFLPQVLFLLLLFGYMVFMMFFKWVVYNDTVEGPLSPACAPSILILFINMILQGSQD 623
            :|:..|.|:|:||::|:|.||||::|::.:||.|       .||...|||||:|||:|:|...|
Zfish   578 RKFQDILLQFVPQLVFMLCLFGYLIFLILYKWSV-------SLSSEMAPSILLLFISMMLFDYQ- 634

  Fly   624 TPEPCKEFMFDGQKSIQQVFVVVAIICIPWMLLGKPLYIMIKR-KTNGAPPPKPQSGGGE----- 682
               |..:.::.|||::|...||.|::.:|.:||.||..|...| ||      :.|..|..
Zfish   635 ---PDHKLLYGGQKAVQICLVVTAVLMVPVLLLVKPFLIYRSRMKT------RHQVFGNSLDDQQ 690

  Fly   683 ---------GHGEDD--EMGEIFIHQAIHTIEYVLSTVSHTASYLRLWALSLAHAQLSEVLWNMV 736
                     .|.:|:  .||::|::||||||||.|..:|:|||||||||||||||:||||||.||
Zfish   691 CTDKRSSFARHQKDETVSMGDVFVYQAIHTIEYCLGCISNTASYLRLWALSLAHAELSEVLWRMV 755

  Fly   737 FSMGFKYDSYIGGILIYVFFGAWALLTVGILVLIEGLSAFLHTLRLHWVEFMSKFYEGAGYAFEP 801
            ...|.|....:|.:::.:.|.|:|:|||.:|:::||||||||.||||||||.:|||||:||.|.|
Zfish   756 LQAGLKLSFGLGSLMLALLFAAFAVLTVTVLLVMEGLSAFLHALRLHWVEFQNKFYEGSGYKFTP 820

  Fly   802 FAFKTILDVSE 812
            .:|.::|...:
Zfish   821 LSFDSLLKTEQ 831

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vha100-5	NP_001260388.1	NtpI	5..805	CDD:224188	374/843 (44%)
Vha100-5	NP_001260388.1	V_ATPase_I	28..804	CDD:279793	361/819 (44%)
si:ch73-173p19.2	XP_021326052.1	V_ATPase_I	28..823	CDD:307581	361/820 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53812
OrthoDB	1	1.010	-	-		D164762at33208
OrthoFinder	1	1.000	-	-		FOG0000328
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100301
Panther	1	1.100	-	-	O	PTHR11629
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X226
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.930