DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vha100-5 and atp6v0a1

DIOPT Version :9

Sequence 1:	NP_001260388.1	Gene:	Vha100-5 / 34587	FlyBaseID:	FBgn0032373	Length:	814	Species:	Drosophila melanogaster
Sequence 2:	XP_031749790.1	Gene:	atp6v0a1 / 100036694	XenbaseID:	XB-GENE-959346	Length:	871	Species:	Xenopus tropicalis

Alignment Length:	862	Identity:	436/862 - (50%)
Similarity:	590/862 - (68%)	Gaps:	65/862 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGDMFRSEKMALCQLFIQPEAAYASIAELGEKGCVQFRDLNEEVSAFQRKYVNEVRRCDDMERRL 65
            ||::||||:|.|.|||:|.||||..::||||.|.|||||||.:|:.||||:|||||||::|:|:|
Frog    27 MGELFRSEEMTLAQLFLQSEAAYCCVSELGELGKVQFRDLNPDVNVFQRKFVNEVRRCEEMDRKL 91

  Fly    66 RYVESEMKKDEVKLPVLRPEEEPIAPNPREIVDLEAQLEKTDNELREMSANGASLDANFRHMQEL 130
            |:||.|:||  ..:.:|...|.|..|.||:::||||..||.:.||:|::.|..:|..||..:.||
Frog    92 RFVEKEVKK--ANISILDTGENPEVPFPRDMIDLEANFEKIEIELKEINTNQEALKRNFLELTEL 154

  Fly   131 KYVLENTEGFFSDQEVINLDVNRKLDP---EDPANL--PGAAQRG---QLAFVAGVIKLERFFSF 187
            |::|..|:.||.:.::.:  ..:..||   |:.::|  |....||   :|.||||||..||..:|
Frog   155 KFILRKTQQFFDEAQLHH--HQQMADPDLLEESSSLLEPSEMGRGAPLRLGFVAGVINRERIPTF 217

  Fly   188 ERMLWRISRGNIFLRRADIDGLVADEETGRPVLKTVFVAFFQGEQLKQRIKKVCTGYHAAVYPCP 252
            ||||||:.|||:|||:|:|:..:.|..||..|.|:||:.||||:|||.|:||:|.|:.|::||||
Frog   218 ERMLWRVCRGNVFLRQAEIENPLEDPVTGDSVHKSVFIIFFQGDQLKNRVKKICEGFRASLYPCP 282

  Fly   253 SSHAERKEMIKDVNVRLEDLKLVLSQSADHRSRVLNSASKHLPRWSIMVRKMKAIYHILNFFNPD 317
            .:..|||||...||.|:|||::||:|:.|||.|||.:|:|.|..|.|.|||||||||.||..|.|
Frog   283 ETPQERKEMATGVNTRIEDLQMVLNQTEDHRQRVLQAAAKSLRVWFIKVRKMKAIYHTLNLCNID 347

  Fly   318 VTGKCLIGEGWVPTNDISTVQDALARASKISESSIPAFMNVIETNEMPPTYTRTNKFTNGFQNLV 382
            ||.||||.|.|.|..|:.::|.||.|.::.|.|::|:.:|.::||:.||||.:|||||.||||||
Frog   348 VTQKCLIAEVWCPVADLDSIQFALRRGTEHSGSTVPSILNRMQTNQTPPTYNKTNKFTYGFQNLV 412

  Fly   383 DSYGMASYREVNPALYACITFPFLFAVMFGDLGHGLILLLFASWLIIKEKQLSS--IKEEIFNIF 445
            |:||:.||||:|||.|..|||||||||||||.|||:::.|||.|::::|.::.|  |..|:|.:.
Frog   413 DAYGIGSYREINPAPYTIITFPFLFAVMFGDFGHGILMTLFAVWMVVRESRILSQKIDNELFTMM 477

  Fly   446 FGGRYIIFLMGIFSIYTGFIYNDVFSKSMNIFGSAWHMN--YTRDVVEDENLKY---ITLRPNDT 505
            |.|||||.|||:||||||.||||.|||::|:|||:|.:.  :| |...::.||:   :.|.||.|
Frog   478 FSGRYIILLMGLFSIYTGLIYNDCFSKALNLFGSSWSVRPMFT-DTWSEDLLKHTSVLQLNPNVT 541

  Fly   506 -VYK-TYPFGMDPIWQLADNKIIFLNTFKMKLSIIVGVIHMIFGVSMSVVNFAYYKKYASIFLEF 568
             |:. .||||:||||.||.||:.|||:||||:|:::|:|||.|||::|::|..|:||..:|:|.|
Frog   542 GVFNGPYPFGIDPIWSLATNKLTFLNSFKMKMSVVLGIIHMTFGVALSLLNHIYFKKPLNIYLGF 606

  Fly   569 LPQVLFLLLLFGYMVFMMFFKWVVYNDTVEGPLSPACAPSILILFINMILQGSQDTPEPCKEFMF 633
            :|:::|:..||||:|.::.:||..|:.:     :...|||:||.||||.|...|||..|   .::
Frog   607 IPEMIFMTTLFGYLVILIIYKWCAYDAS-----TSMVAPSLLIHFINMFLFSYQDTSLP---MLY 663

  Fly   634 DGQKSIQQVFVVVAIICIPWMLLGKPLYI---MIKRKTNGAPPPKPQSGG---GEG--------- 683
            .||..:|...||.||||:||||:.|||.:   .::||..|.    ...||   |.|
Frog   664 KGQMGLQCFLVVCAIICVPWMLVVKPLILRRQYLRRKHLGT----HNFGGIRVGNGPTEEDAEII 724

  Fly   684 ----------HGEDDEMGEIF------IHQAIHTIEYVLSTVSHTASYLRLWALSLAHAQLSEVL 732
                      .||:..|.|:|      :|||||||||.|..:|:|||||||||||||||||||||
Frog   725 QHDQLSMHSEEGEEPAMEEVFDFGDTVVHQAIHTIEYCLGCISNTASYLRLWALSLAHAQLSEVL 789

  Fly   733 WNMVFSMGFKYDSYIGGILIYVFFGAWALLTVGILVLIEGLSAFLHTLRLHWVEFMSKFYEGAGY 797
            |.||..:|....|..|||.:...|.|:|.||:.||:::||||||||.||||||||.:|||.|.|:
Frog   790 WTMVMHVGLSIRSLGGGIALVFVFSAFATLTIAILLIMEGLSAFLHALRLHWVEFQNKFYMGTGF 854

  Fly   798 AFEPFAFKTILDVSEDD 814
            .|.||:|:.|.:...|:
Frog   855 KFLPFSFENIREGKFDE 871

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vha100-5	NP_001260388.1	NtpI	5..805	CDD:224188	431/847 (51%)
Vha100-5	NP_001260388.1	V_ATPase_I	28..804	CDD:279793	417/823 (51%)
atp6v0a1	XP_031749790.1	V_ATPase_I	53..861	CDD:396194	417/824 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53812
OrthoDB	1	1.010	-	-		D164762at33208
OrthoFinder	1	1.000	-	-		FOG0000328
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11629
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X226
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.030