DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kek2 and LINGO1

DIOPT Version :9

Sequence 1:	NP_523551.1	Gene:	kek2 / 34582	FlyBaseID:	FBgn0015400	Length:	894	Species:	Drosophila melanogaster
Sequence 2:	NP_116197.4	Gene:	LINGO1 / 84894	HGNCID:	21205	Length:	620	Species:	Homo sapiens

Alignment Length:	589	Identity:	121/589 - (20%)
Similarity:	197/589 - (33%)	Gaps:	219/589 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LPIWIPLLALL------AITAACPPEVCVCKWKGGKQTVECGGQQLSNLPEGMDPGTQVLNFSGN 62
            |..|.|:|.|:      .....|||.   |:.....:.|.|..::...:|||:...|::|:...|
Human    20 LACWQPILLLVLGSVLSGSATGCPPR---CECSAQDRAVLCHRKRFVAVPEGIPTETRLLDLGKN 81

  Fly    63 ALQVLQSERFLRM----------------------DLLNLQKIYLSRNQLIRIHEKAFRGLTNLV 105
            .::.|..:.|...                      :|.||:.:.|..|:|..|....|.||:||.
Human    82 RIKTLNQDEFASFPHLEELELNENIVSAVEPGAFNNLFNLRTLGLRSNRLKLIPLGVFTGLSNLT 146

  Fly   106 ELDLSENALQNVPSETFQDYSSLMRLSLSGNP--------------------------------- 137
            :||:|||.:..:....|||..:|..|.:..|.
Human   147 KLDISENKIVILLDYMFQDLYNLKSLEVGDNDLVYISHRAFSGLNSLEQLTLEKCNLTSIPTEAL 211

  Fly   138 ----------IRELKTSAFRHLSF-----------------------------LTTLELSNC--- 160
                      :|.|..:|.|..||                             ||:|.:::|
Human   212 SHLHGLIVLRLRHLNINAIRDYSFKRLYRLKVLEISHWPYLDTMTPNCLYGLNLTSLSITHCNLT 276

  Fly   161 ---------------------------------------------QVERIENEAFVGMDNLEWLR 180
                                                         |:..:|..||.|::.|..|.
Human   277 AVPYLAVRHLVYLRFLNLSYNPISTIEGSMLHELLRLQEIQLVGGQLAVVEPYAFRGLNYLRVLN 341

  Fly   181 LDGNRIGFIQGT--HILPKSLHGISLHSNRWNCDCRLLDI--HFWLVNYNTPLAEEPKCMEPARL 241
            :.||::..::.:  |.: .:|..:.|.||...||||||.:  ..|.:|:|   .::|.|..|..:
Human   342 VSGNQLTTLEESVFHSV-GNLETLILDSNPLACDCRLLWVFRRRWRLNFN---RQQPTCATPEFV 402

  Fly   242 KGQVIKSLQREQLACLPEVSPQSSYT--------------EVSEGRNMSITCLVRAIPEPKVLWL 292
            :|:..|.        .|:|...:.:|              .|.||..:...|.....|.|.:|||
Human   403 QGKEFKD--------FPDVLLPNYFTCRRARIRDRKAQQVFVDEGHTVQFVCRADGDPPPAILWL 459

  Fly   293 FNGQVMSNDSLMDNLHMYYYIDETIGVSGAEEKRSEIFIYNVGAEDNGTFSCVGQNIAGT----- 352
            ...:.:.  |...|..:..:.|.|:.|..|:            .:||||:.|:..|..|.
Human   460 SPRKHLV--SAKSNGRLTVFPDGTLEVRYAQ------------VQDNGTYLCIAANAGGNDSMPA 510

  Fly   353 -----TFS-------NYTLRVIIKEP------PVVNEVSFPRDYMNYIVASSAGG-GIIFVVLLC 398
                 ::|       |.|...|..:|      .....|.||.|....|:|::.|. ..:.|||.|
Human   511 HLHVRSYSPDWPHQPNKTFAFISNQPGEGEANSTRATVPFPFDIKTLIIATTMGFISFLGVVLFC 575

  Fly   399 TIVV 402
            .:::
Human   576 LVLL 579

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek2	NP_523551.1	leucine-rich repeat	34..52	CDD:275380	5/17 (29%)
		leucine-rich repeat	54..79	CDD:275380	6/46 (13%)
		LRR_8	79..138	CDD:290566	22/101 (22%)
		LRR_RI	<80..187	CDD:238064	40/226 (18%)
		leucine-rich repeat	80..103	CDD:275380	8/22 (36%)
		leucine-rich repeat	104..127	CDD:275380	9/22 (41%)
		LRR_8	126..186	CDD:290566	22/179 (12%)
		leucine-rich repeat	128..151	CDD:275380	7/65 (11%)
		leucine-rich repeat	152..175	CDD:275380	9/70 (13%)
		leucine-rich repeat	176..198	CDD:275380	5/23 (22%)
		TPKR_C2	207..256	CDD:301599	15/50 (30%)
		I-set	258..361	CDD:254352	28/133 (21%)
		Ig_2	263..361	CDD:290606	26/128 (20%)
LINGO1	NP_116197.4	LRRNT	41..75	CDD:214470	10/36 (28%)
		LRR	<66..371	CDD:227223	55/305 (18%)
		LRR 1	72..93		5/20 (25%)
		leucine-rich repeat	73..96	CDD:275380	5/22 (23%)
		LRR 2	96..117		0/20 (0%)
		leucine-rich repeat	97..120	CDD:275380	1/22 (5%)
		LRR_8	120..179	CDD:338972	22/58 (38%)
		LRR 3	120..141		7/20 (35%)
		leucine-rich repeat	121..144	CDD:275380	8/22 (36%)
		LRR 4	144..165		8/20 (40%)
		leucine-rich repeat	145..192	CDD:275380	12/46 (26%)
		LRR 5	168..189		3/20 (15%)
		LRR 6	192..213		0/20 (0%)
		leucine-rich repeat	193..216	CDD:275380	0/22 (0%)
		LRR 7	216..237		6/20 (30%)
		leucine-rich repeat	217..264	CDD:275380	6/46 (13%)
		LRR 8	264..285		4/20 (20%)
		leucine-rich repeat	265..288	CDD:275380	4/22 (18%)
		LRR 9	288..309		0/20 (0%)
		leucine-rich repeat	289..312	CDD:275380	0/22 (0%)
		LRR 10	312..333		4/20 (20%)
		leucine-rich repeat	313..336	CDD:275380	5/22 (23%)
		LRR 11	336..357		4/20 (20%)
		leucine-rich repeat	337..357	CDD:275380	4/19 (21%)
		PCC	341..>421	CDD:188093	23/91 (25%)
		Ig	439..514	CDD:386229	20/88 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm41933
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910