DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek2 and SLITRK2

DIOPT Version :9

Sequence 1:	NP_523551.1	Gene:	kek2 / 34582	FlyBaseID:	FBgn0015400	Length:	894	Species:	Drosophila melanogaster
Sequence 2:	NP_001137475.1	Gene:	SLITRK2 / 84631	HGNCID:	13449	Length:	845	Species:	Homo sapiens

Alignment Length:	572	Identity:	127/572 - (22%)
Similarity:	206/572 - (36%)	Gaps:	153/572 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 ITAACPPEVCVCKWKGGKQ--TVECGGQQLSNL----PEGMDPGTQVLNFSGNALQVLQSERFLR 74
            :...||.. |||..:....  .|.|..::.:|:    |:...|  :.|..:||.||.:.....|.
Human   336 VPLTCPSS-CVCTSQSSDNGLNVNCQERKFTNISDLQPKPTSP--KKLYLTGNYLQTVYKNDLLE 397

  Fly    75 MDLLNLQKIYLSRNQLIRIHEKAFRGLTNLVELDLSENALQNVPSETFQDYSSLMRLSLSGNPIR 139
            ...|:|  ::|..|::..|.|.||..||:|..|.|:.|.|:.:....|....||..|.|..|.|:
Human   398 YSSLDL--LHLGNNRIAVIQEGAFTNLTSLRRLYLNGNYLEVLYPSMFDGLQSLQYLYLEYNVIK 460

  Fly   140 ELKTSAFRHLSFLTTLELSNCQVERIENEAFVGMDNLEWLRLDGNRIGFIQGTHILPK--SLHGI 202
            |:|...|..|..|..|.|:|..:..:.:..| |...|..|.|..|....:....:|.:  :...|
Human   461 EIKPLTFDALINLQLLFLNNNLLRSLPDNIF-GGTALTRLNLRNNHFSHLPVKGVLDQLPAFIQI 524

  Fly   203 SLHSNRWNCDCRLLDIHFWLVNYNTP-LAEEPKCMEPARLKGQVIKSLQREQLACLPE------- 259
            .|..|.|:|.|.::.:..|..:.|:| :..|..|..||:..|:::|.|.||  |..|:
Human   525 DLQENPWDCTCDIMGLKDWTEHANSPVIINEVTCESPAKHAGEILKFLGRE--AICPDSPNLSDG 587

  Fly   260 ----------------VSPQSSYTE---------------------VSEGRNMSITCLVRAIPEP 287
                            ||| |||.|                     |..|..:.:..|.|....|
Human   588 TVLSMNHNTDTPRSLSVSP-SSYPELHTEVPLSVLILGLLVVFILSVCFGAGLFVFVLKRRKGVP 651

  Fly   288 KVLWLFNGQVMSNDSLM-----------DNLHMYYYIDETIGVSGAEEKRSEIFIYNVGAEDNGT 341
            .|....|...:|:..|.           .:.|:|.||...:|    :..::.|::     :..|.
Human   652 SVPRNTNNLDVSSFQLQYGSYNTETHDKTDGHVYNYIPPPVG----QMCQNPIYM-----QKEGD 707

  Fly   342 FSCVGQNIAGTTFSNYTLRVIIKEPP-----------VVNEVSFPRD----YMNYI--VASSAGG 389
            .....:|:...::||...:   ||.|           ::.:.:.||:    |.|..  |......
Human   708 PVAYYRNLQEFSYSNLEEK---KEEPATPAYTISATELLEKQATPREPELLYQNIAERVKELPSA 769

  Fly   390 GIIFVVLLCTIVVKCKKTSEPAKQRKKCDQVTSIAGGTDSSTGSTQDTGMGMMKCASILNDGGDS 454
            |::. ...||:.   |:...|:.:.::.:|                                 |.
Human   770 GLVH-YNFCTLP---KRQFAPSYESRRQNQ---------------------------------DR 797

  Fly   455 MNGNPGLLLGDTLTPTKAANGAAGGGIILGNQMKQNLLLYATPNSAQQQLQL 506
            :|..  :|.|   ||.|.         .:|.....:.||.|.|.|....|::
Human   798 INKT--VLYG---TPRKC---------FVGQSKPNHPLLQAKPQSEPDYLEV 835

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek2	NP_523551.1	leucine-rich repeat	34..52	CDD:275380	4/23 (17%)
		leucine-rich repeat	54..79	CDD:275380	6/24 (25%)
		LRR_8	79..138	CDD:290566	20/58 (34%)
		LRR_RI	<80..187	CDD:238064	35/106 (33%)
		leucine-rich repeat	80..103	CDD:275380	8/22 (36%)
		leucine-rich repeat	104..127	CDD:275380	6/22 (27%)
		LRR_8	126..186	CDD:290566	20/59 (34%)
		leucine-rich repeat	128..151	CDD:275380	9/22 (41%)
		leucine-rich repeat	152..175	CDD:275380	6/22 (27%)
		leucine-rich repeat	176..198	CDD:275380	5/23 (22%)
		TPKR_C2	207..256	CDD:301599	16/49 (33%)
		I-set	258..361	CDD:254352	27/157 (17%)
		Ig_2	263..361	CDD:290606	23/129 (18%)
SLITRK2	NP_001137475.1	LRR 1	63..84
		leucine-rich repeat	67..87	CDD:275380
		LRR_RI	<82..>217	CDD:238064
		LRR_8	86..146	CDD:290566
		LRR 2	87..108
		leucine-rich repeat	88..111	CDD:275380
		LRR 3	111..132
		leucine-rich repeat	112..135	CDD:275380
		LRR_8	135..193	CDD:290566
		LRR 4	135..156
		leucine-rich repeat	136..159	CDD:275380
		LRR 5	159..180
		leucine-rich repeat	160..181	CDD:275380
		Required for interaction with PTPRD. /evidence=ECO:0000250\|UniProtKB:Q810C0	167..215
		leucine-rich repeat	208..369	CDD:275380	8/33 (24%)
		TPKR_C2	216..>252	CDD:301599
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	263..321
		leucine-rich repeat	370..400	CDD:275380	8/31 (26%)
		LRR 7	376..397		6/22 (27%)
		LRR_8	399..459	CDD:290566	21/61 (34%)
		LRR 8	400..421		8/22 (36%)
		leucine-rich repeat	401..424	CDD:275380	9/24 (38%)
		LRR_4	423..466	CDD:289563	15/42 (36%)
		LRR 9	424..445		6/20 (30%)
		leucine-rich repeat	425..448	CDD:275380	6/22 (27%)
		LRR 10	448..469		9/20 (45%)
		leucine-rich repeat	449..468	CDD:275380	7/18 (39%)
		LRR 11	472..493		5/21 (24%)
		leucine-rich repeat	473..491	CDD:275380	4/17 (24%)
		LRR 12	495..516		4/20 (20%)
		leucine-rich repeat	496..509	CDD:275378	4/12 (33%)
		leucine-rich repeat	521..533	CDD:275378	4/11 (36%)
		LRRCT	529..579	CDD:214507	17/51 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000