DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kek2 and LRRC3

DIOPT Version :9

Sequence 1:	NP_523551.1	Gene:	kek2 / 34582	FlyBaseID:	FBgn0015400	Length:	894	Species:	Drosophila melanogaster
Sequence 2:	NP_112153.1	Gene:	LRRC3 / 81543	HGNCID:	14965	Length:	257	Species:	Homo sapiens

Alignment Length:	172	Identity:	53/172 - (30%)
Similarity:	74/172 - (43%)	Gaps:	21/172 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LLALLAITAACPPEVCVCKWKGGKQTVECGGQQLSNLPEGMDPGTQVLNFSGNALQVLQSERFLR 74
            ||..|.:.||| |:.|.|....|...|.|..:.|..:||.:...|.:|....|.:..|....|
Human    23 LLFCLHLGAAC-PQPCRCPDHAGAVAVFCSLRGLQEVPEDIPANTVLLKLDANKISHLPDGAF-- 84

  Fly    75 MDLLNLQKIYLSRNQLIRIHEKAFRGLT-NLVELDLSENALQNVPSETFQDYSSLMRLSLSGNPI 138
            ..|..|:::.||.|.:..|....|.||. .|..||||.|.:|.:|.:.....|:.:|  ||.||:
Human    85 QHLHRLRELDLSHNAIEAIGSATFAGLAGGLRLLDLSYNRIQRIPKDALGKLSAKIR--LSHNPL 147

  Fly   139 R---ELKTSAFRHLSFLTTLELSNCQVERIE-----NEAFVG 172
            .   .|:.:       |..|:|....|:.|.     .|.|||
Human   148 HCECALQEA-------LWELKLDPDSVDEIACHTSVQEEFVG 182

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek2	NP_523551.1	leucine-rich repeat	34..52	CDD:275380	5/17 (29%)
		leucine-rich repeat	54..79	CDD:275380	6/24 (25%)
		LRR_8	79..138	CDD:290566	21/59 (36%)
		LRR_RI	<80..187	CDD:238064	32/102 (31%)
		leucine-rich repeat	80..103	CDD:275380	8/23 (35%)
		leucine-rich repeat	104..127	CDD:275380	8/22 (36%)
		LRR_8	126..186	CDD:290566	16/55 (29%)
		leucine-rich repeat	128..151	CDD:275380	6/25 (24%)
		leucine-rich repeat	152..175	CDD:275380	9/26 (35%)
		leucine-rich repeat	176..198	CDD:275380
		TPKR_C2	207..256	CDD:301599
		I-set	258..361	CDD:254352
		Ig_2	263..361	CDD:290606
LRRC3	NP_112153.1	LRRNT	32..68	CDD:214470	12/36 (33%)
		leucine-rich repeat	48..65	CDD:275378	5/16 (31%)
		LRR 1	65..86		5/22 (23%)
		leucine-rich repeat	66..89	CDD:275378	6/24 (25%)
		LRR_8	69..125	CDD:290566	19/57 (33%)
		LRR_4	69..103	CDD:289563	9/35 (26%)
		LRR_4	89..129	CDD:289563	15/39 (38%)
		LRR 2	89..110		6/20 (30%)
		leucine-rich repeat	90..114	CDD:275378	8/23 (35%)
		LRR 3	114..135		8/20 (40%)
		leucine-rich repeat	115..138	CDD:275378	8/22 (36%)
		LRR 4	136..157		7/29 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000