DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek2 and lrrc24

DIOPT Version :9

Sequence 1:	NP_523551.1	Gene:	kek2 / 34582	FlyBaseID:	FBgn0015400	Length:	894	Species:	Drosophila melanogaster
Sequence 2:	XP_031759297.1	Gene:	lrrc24 / 779773	XenbaseID:	XB-GENE-923418	Length:	569	Species:	Xenopus tropicalis

Alignment Length:	460	Identity:	122/460 - (26%)
Similarity:	195/460 - (42%)	Gaps:	52/460 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 IPLLALLAITAACPPEVCVCKWKGGKQTVECGGQQLSNLPEGMDPGTQVLNFSGNALQVLQSERF 72
            :|:|..|. |..||.| |.|.    ..|||||.::|.::|..:.|.||.:....||:..:|
Frog    44 LPVLLALG-TQGCPAE-CRCY----SMTVECGSKELRSVPSSIHPSTQTVFLQDNAISQIQ---- 98

  Fly    73 LRMD---LLNLQKIYLSRNQLIRIHEKAFRGLTNLVELDLSENALQNVPSETFQDYSSLMRLSLS 134
             ::|   |..||.:||..|.:..:...||:...:|:||.|:.|.:..:.|..|:....|..|.|:
Frog    99 -QLDLSPLSGLQYLYLQNNSISALEPGAFKSQQHLLELALNGNRIHLINSSIFKGLEHLRVLYLA 162

  Fly   135 GNPIRELKTSAFRHLSFLTTLELSNCQVERIENEAFVGMDNLEWLRLDGNRIGFIQGTHILPK-S 198
            ||.|..|....|..|..|..|.|....:|.::::||.|:.:|..|.|..|.:..|..:.:.|. |
Frog   163 GNQITRLLAYTFSDLQRLQELHLQENSIETLQDQAFSGLSSLALLDLSKNNMRTISRSALRPLIS 227

  Fly   199 LHGISLHSNRWNCDCRLLDIHFWLVNYN----TPLAEEPKCMEPARLKGQVIKSLQREQLACLPE 259
            |..:.|..|.|.|||.|..:..|:.:..    :.|.::..|.||.||..|.:..:....|.|:|.
Frog   228 LQVLRLTENPWRCDCALHWLRAWIKDEGQRLLSSLDKKIICSEPPRLLHQSLVDISGNSLVCIPP 292

  Fly   260 ---VSPQSSYTEVSE--GRNMSITCLVRAIPEPKVLWLFNGQVMSNDSLMD----NLHMYYYIDE 315
               |.|.    ||:.  |..:.::|.....|:|.|.|.......:....::    :...:...:.
Frog   293 MVLVEPM----EVTARLGEELRVSCRATGYPQPLVTWRKVSHARTGPPKINVKSTSSRKFELSER 353

  Fly   316 TIGVS-GAEEKRSEIFIYNVGAEDNGTFSCVGQNIAGT---------TFSN-----YTLRVIIKE 365
            ::|.. .|......:|:.|:.....|.:.||..|..||         ..||     ||...|.:|
Frog   354 SVGEQFDAATGSGMLFLNNISMSHAGKYECVASNPGGTAKVLFHLAVNLSNQQSRTYTSADISQE 418

  Fly   366 PPV-VNEVSFPRDYMNYIVASSAGGGIIFVVLLCTIVVKCKKTSEPAKQRKKCDQVTSIAGGTDS 429
            |.. :..:.|....|....|.:.|..::.:..:..||:..:|    ..:|||..:..:|....|.
Frog   419 PLYDLESMEFNALSMATQTAIAIGISLLALTAMLLIVMIYRK----HHKRKKAKKEENILYVNDY 479

  Fly   430 STGST 434
            |.|.|
Frog   480 SDGPT 484

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek2	NP_523551.1	leucine-rich repeat	34..52	CDD:275380	7/17 (41%)
		leucine-rich repeat	54..79	CDD:275380	7/27 (26%)
		LRR_8	79..138	CDD:290566	19/58 (33%)
		LRR_RI	<80..187	CDD:238064	34/106 (32%)
		leucine-rich repeat	80..103	CDD:275380	7/22 (32%)
		leucine-rich repeat	104..127	CDD:275380	7/22 (32%)
		LRR_8	126..186	CDD:290566	20/59 (34%)
		leucine-rich repeat	128..151	CDD:275380	9/22 (41%)
		leucine-rich repeat	152..175	CDD:275380	7/22 (32%)
		leucine-rich repeat	176..198	CDD:275380	6/22 (27%)
		TPKR_C2	207..256	CDD:301599	15/52 (29%)
		I-set	258..361	CDD:254352	25/126 (20%)
		Ig_2	263..361	CDD:290606	22/118 (19%)
lrrc24	XP_031759297.1	LRRNT	54..85	CDD:214470	13/35 (37%)
		leucine-rich repeat	65..83	CDD:275380	7/17 (41%)
		leucine-rich repeat	84..107	CDD:275380	7/27 (26%)
		PPP1R42	87..>236	CDD:411060	44/153 (29%)
		LRR_8	106..166	CDD:404697	19/59 (32%)
		leucine-rich repeat	108..131	CDD:275380	7/22 (32%)
		leucine-rich repeat	132..155	CDD:275380	7/22 (32%)
		leucine-rich repeat	156..179	CDD:275380	9/22 (41%)
		leucine-rich repeat	180..203	CDD:275380	7/22 (32%)
		leucine-rich repeat	204..227	CDD:275380	6/22 (27%)
		LRRCT	236..289	CDD:214507	15/52 (29%)
		Ig_3	291..387	CDD:404760	18/99 (18%)
		Ig strand A	291..295	CDD:409353	1/3 (33%)
		Ig strand A'	300..304	CDD:409353	2/3 (67%)
		Ig strand B	307..316	CDD:409353	1/8 (13%)
		Ig strand C	322..328	CDD:409353	2/5 (40%)
		Ig strand C'	345..348	CDD:409353	0/2 (0%)
		Ig strand D	356..359	CDD:409353	1/2 (50%)
		Ig strand E	366..372	CDD:409353	1/5 (20%)
		Ig strand F	379..387	CDD:409353	3/7 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm14083
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.910