DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek2 and Lrrc4

DIOPT Version :9

Sequence 1:	NP_523551.1	Gene:	kek2 / 34582	FlyBaseID:	FBgn0015400	Length:	894	Species:	Drosophila melanogaster
Sequence 2:	NP_001032413.1	Gene:	Lrrc4 / 641521	RGDID:	1560026	Length:	652	Species:	Rattus norvegicus

Alignment Length:	509	Identity:	130/509 - (25%)
Similarity:	198/509 - (38%)	Gaps:	125/509 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 IWIPLLALLAITAACP---PEVCVCKWKGGKQTVECGGQQLSNLPEGMDPGTQVLNFSGNALQVL 67
            :||...|:.|..:|.|   |.||.|..:..|  |.|..:.||.:|:|:...|:.||...|.:|::
  Rat    27 VWILCAAIAAAASAGPQNCPSVCSCSNQFSK--VVCTRRGLSEVPQGIPSNTRYLNLMENNIQMI 89

  Fly    68 QSERFLRMDLLNLQKIYLSRNQLIRIHEKAFRGLTNLVELDLSENALQNVPSETFQDYSSLMRLS 132
            |::.|  ..|.:|:.:.|.||.:.:|...||.||.:|..|:|.:|.|..:||..|:..|.|..|.
  Rat    90 QADTF--RHLHHLEVLQLGRNAIRQIEVGAFNGLASLNTLELFDNWLTVIPSGAFEYLSKLRELW 152

  Fly   133 LSGNPIRELKTSAFRHLSFLTTLELSNC-QVERIENEAFVGMDNLEWLRLDGNRI---------- 186
            |..|||..:.:.||..:..|..|:|... ::|.|...||.|:.||::|.|....|
  Rat   153 LRNNPIESIPSYAFNRVPSLMRLDLGELKKLEYISEGAFEGLFNLKYLNLGMCNIKDMPNLTPLV 217

  Fly   187 GF----IQGTH---ILPKSLHGIS----------------------------------------- 203
            |.    :.|.|   |.|.|.||:|
  Rat   218 GLEELEMSGNHFPEIRPGSFHGLSSLKKLWVMNSQVSLIERNAFDGLASLVELNLAHNNLSSLPH 282

  Fly   204 -------------LHSNRWNCDCRLLDIHFWLVNY---NTPLAEEPKCMEPARLKGQVIKSLQRE 252
                         ||.|.|||||.:|.:.:||..|   |:...  .:|..|..::|:.:..:.:.
  Rat   283 DLFTPLRYLVELHLHHNPWNCDCDILWLAWWLREYIPTNSTCC--GRCHAPMHMRGRYLVEVDQA 345

  Fly   253 QLAC-LPEVSPQSSYTEVSEGRNMSITCLVRAIPEPKVLWLF-NGQVMSNDSLMDNLHMYYYIDE 315
            ...| .|.:........:||.|...:.|  |..|...|.||. ||.|:|:.|....:.:..  |.
  Rat   346 SFQCSAPFIMDAPRDLNISEDRMAELKC--RTPPMSSVKWLLPNGTVLSHASRHPRISVLN--DG 406

  Fly   316 TIGVSGAEEKRSEIFIYNVGAEDNGTFSCVGQNIAGTTFSNYTLRVIIKEPPVVNEVSFPRDYMN 380
            |:..|            .|...|.|.::|:..|:||.:.::..|.|...|   :|..:|.
  Rat   407 TLNFS------------RVLLIDTGVYTCMVTNVAGNSNASAYLNVSSAE---LNTPNFS----- 451

  Fly   381 YIVASSAGGGIIFVVLLCTIVVKCKKTSEPAKQRKKCDQVTSIAGGTDSSTGST 434
                           ...|:.|:..:.|.....||.....|:..|...:.|.||
  Rat   452 ---------------FFTTVTVETTEISPEDITRKYKPVPTTSTGYQPAYTTST 490

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek2	NP_523551.1	leucine-rich repeat	34..52	CDD:275380	6/17 (35%)
		leucine-rich repeat	54..79	CDD:275380	8/24 (33%)
		LRR_8	79..138	CDD:290566	22/58 (38%)
		LRR_RI	<80..187	CDD:238064	39/117 (33%)
		leucine-rich repeat	80..103	CDD:275380	9/22 (41%)
		leucine-rich repeat	104..127	CDD:275380	8/22 (36%)
		LRR_8	126..186	CDD:290566	21/60 (35%)
		leucine-rich repeat	128..151	CDD:275380	8/22 (36%)
		leucine-rich repeat	152..175	CDD:275380	8/23 (35%)
		leucine-rich repeat	176..198	CDD:275380	9/38 (24%)
		TPKR_C2	207..256	CDD:301599	14/51 (27%)
		I-set	258..361	CDD:254352	26/103 (25%)
		Ig_2	263..361	CDD:290606	25/98 (26%)
Lrrc4	NP_001032413.1	LRRNT	45..78	CDD:214470	12/34 (35%)
		LRR_8	74..132	CDD:404697	20/59 (34%)
		LRR 1	75..96		7/22 (32%)
		leucine-rich repeat	76..99	CDD:275380	8/24 (33%)
		PPP1R42	96..300	CDD:411060	51/203 (25%)
		LRR 2	99..120		7/20 (35%)
		leucine-rich repeat	100..123	CDD:275380	9/22 (41%)
		LRR 3	123..144		8/20 (40%)
		leucine-rich repeat	124..147	CDD:275380	8/22 (36%)
		LRR 4	147..168		8/20 (40%)
		leucine-rich repeat	148..171	CDD:275380	8/22 (36%)
		LRR 5	171..193		7/21 (33%)
		leucine-rich repeat	172..196	CDD:275380	8/23 (35%)
		LRR 6	196..217		5/20 (25%)
		leucine-rich repeat	197..218	CDD:275380	4/20 (20%)
		LRR 7	218..239		6/20 (30%)
		leucine-rich repeat	219..242	CDD:275380	7/22 (32%)
		LRR 8	242..263		0/20 (0%)
		leucine-rich repeat	243..266	CDD:275380	0/22 (0%)
		LRR 9	266..287		0/20 (0%)
		leucine-rich repeat	267..288	CDD:275380	0/20 (0%)
		LRRCT	299..350	CDD:214507	14/52 (27%)
		IG_like	358..440	CDD:214653	25/97 (26%)
		Ig strand B	369..373	CDD:409353	0/3 (0%)
		Ig strand C	380..384	CDD:409353	1/3 (33%)
		Ig strand E	406..410	CDD:409353	1/3 (33%)
		Ig strand F	420..425	CDD:409353	1/4 (25%)
		Ig strand G	433..436	CDD:409353	0/2 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46071
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910