DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek2 and LRRC4

DIOPT Version :9

Sequence 1:	NP_523551.1	Gene:	kek2 / 34582	FlyBaseID:	FBgn0015400	Length:	894	Species:	Drosophila melanogaster
Sequence 2:	NP_071426.1	Gene:	LRRC4 / 64101	HGNCID:	15586	Length:	653	Species:	Homo sapiens

Alignment Length:	575	Identity:	146/575 - (25%)
Similarity:	222/575 - (38%)	Gaps:	145/575 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 IWIPLLALLAITAACP---PEVCVCKWKGGKQTVECGGQQLSNLPEGMDPGTQVLNFSGNALQVL 67
            :||...|:.|..:|.|   |.||.|..:..|  |.|..:.||.:|:|:...|:.||...|.:|::
Human    28 VWILCAAIAAAASAGPQNCPSVCSCSNQFSK--VVCTRRGLSEVPQGIPSNTRYLNLMENNIQMI 90

  Fly    68 QSERFLRMDLLNLQKIYLSRNQLIRIHEKAFRGLTNLVELDLSENALQNVPSETFQDYSSLMRLS 132
            |::.|  ..|.:|:.:.|.||.:.:|...||.||.:|..|:|.:|.|..:||..|:..|.|..|.
Human    91 QADTF--RHLHHLEVLQLGRNSIRQIEVGAFNGLASLNTLELFDNWLTVIPSGAFEYLSKLRELW 153

  Fly   133 LSGNPIRELKTSAFRHLSFLTTLELSNC-QVERIENEAFVGMDNLEWLRLDGNRI---------- 186
            |..|||..:.:.||..:..|..|:|... ::|.|...||.|:.||::|.|....|
Human   154 LRNNPIESIPSYAFNRVPSLMRLDLGELKKLEYISEGAFEGLFNLKYLNLGMCNIKDMPNLTPLV 218

  Fly   187 GF----IQGTH---ILPKSLHGIS----------------------------------------- 203
            |.    :.|.|   |.|.|.||:|
Human   219 GLEELEMSGNHFPEIRPGSFHGLSSLKKLWVMNSQVSLIERNAFDGLASLVELNLAHNNLSSLPH 283

  Fly   204 -------------LHSNRWNCDCRLLDIHFWLVNY---NTPLAEEPKCMEPARLKGQVIKSLQRE 252
                         ||.|.|||||.:|.:.:||..|   |:...  .:|..|..::|:.:..:.:.
Human   284 DLFTPLRYLVELHLHHNPWNCDCDILWLAWWLREYIPTNSTCC--GRCHAPMHMRGRYLVEVDQA 346

  Fly   253 QLAC-LPEVSPQSSYTEVSEGRNMSITCLVRAIPEPKVLWLF-NGQVMSNDSLMDNLHMYYYIDE 315
            ...| .|.:........:||||...:.|  |..|...|.||. ||.|:|:.|....:.:..  |.
Human   347 SFQCSAPFIMDAPRDLNISEGRMAELKC--RTPPMSSVKWLLPNGTVLSHASRHPRISVLN--DG 407

  Fly   316 TIGVSGAEEKRSEIFIYNVGAEDNGTFSCVGQNIAGTTFSNYTLRVIIKEPPVVNEVSFPRDYMN 380
            |:..|            :|...|.|.::|:..|:||.:.::..|.|...|....|...|
Human   408 TLNFS------------HVLLSDTGVYTCMVTNVAGNSNASAYLNVSTAELNTSNYSFF------ 454

  Fly   381 YIVASSAGGGIIFVVLLCTIVVKCKKTSEPAKQRKKCDQVTSIAGG-----TDSSTGSTQDTGMG 440
                             .|:.|:..:.| |....:|...|.:.:.|     |.|:|...|.|.:
Human   455 -----------------TTVTVETTEIS-PEDTTRKYKPVPTTSTGYQPAYTTSTTVLIQTTRV- 500

  Fly   441 MMKCASILNDGGDSMNGNPGLLLGDTLTPTKAANGAAGGGIILGNQMKQNLLLYA 495
            ..:.|....|..|.|..:    |.:.:..||         ||:|..:...||..|
Human   501 PKQVAVPATDTTDKMQTS----LDEVMKTTK---------IIIGCFVAVTLLAAA 542

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek2	NP_523551.1	leucine-rich repeat	34..52	CDD:275380	6/17 (35%)
		leucine-rich repeat	54..79	CDD:275380	8/24 (33%)
		LRR_8	79..138	CDD:290566	22/58 (38%)
		LRR_RI	<80..187	CDD:238064	39/117 (33%)
		leucine-rich repeat	80..103	CDD:275380	9/22 (41%)
		leucine-rich repeat	104..127	CDD:275380	8/22 (36%)
		LRR_8	126..186	CDD:290566	21/60 (35%)
		leucine-rich repeat	128..151	CDD:275380	8/22 (36%)
		leucine-rich repeat	152..175	CDD:275380	8/23 (35%)
		leucine-rich repeat	176..198	CDD:275380	9/38 (24%)
		TPKR_C2	207..256	CDD:301599	14/51 (27%)
		I-set	258..361	CDD:254352	27/103 (26%)
		Ig_2	263..361	CDD:290606	26/98 (27%)
LRRC4	NP_071426.1	LRRNT	46..79	CDD:214470	12/34 (35%)
		LRR	<74..291	CDD:227223	56/218 (26%)
		LRR 1	76..97		7/22 (32%)
		leucine-rich repeat	77..100	CDD:275380	8/24 (33%)
		LRR 2	100..121		7/20 (35%)
		leucine-rich repeat	101..124	CDD:275380	9/22 (41%)
		LRR 3	124..145		8/20 (40%)
		leucine-rich repeat	125..148	CDD:275380	8/22 (36%)
		LRR 4	148..169		8/20 (40%)
		leucine-rich repeat	149..172	CDD:275380	8/22 (36%)
		LRR 5	172..194		7/21 (33%)
		leucine-rich repeat	173..197	CDD:275380	8/23 (35%)
		LRR 6	197..218		5/20 (25%)
		leucine-rich repeat	198..219	CDD:275380	4/20 (20%)
		LRR 7	219..240		6/20 (30%)
		leucine-rich repeat	220..243	CDD:275380	7/22 (32%)
		LRR 8	243..264		0/20 (0%)
		leucine-rich repeat	244..267	CDD:275380	0/22 (0%)
		LRR 9	267..288		0/20 (0%)
		leucine-rich repeat	268..289	CDD:275380	0/20 (0%)
		LRRCT	300..351	CDD:214507	14/52 (27%)
		IG	359..441	CDD:214652	26/97 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm41933
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910