DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek2 and LRFN1

DIOPT Version :9

Sequence 1:	NP_523551.1	Gene:	kek2 / 34582	FlyBaseID:	FBgn0015400	Length:	894	Species:	Drosophila melanogaster
Sequence 2:	NP_065913.1	Gene:	LRFN1 / 57622	HGNCID:	29290	Length:	771	Species:	Homo sapiens

Alignment Length:	846	Identity:	186/846 - (21%)
Similarity:	293/846 - (34%)	Gaps:	249/846 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSGLPIWIPLLALLAITAA----CPPEVCVCKWKGGKQTVECGGQQLSNLPEGMDPGTQVLNFSG 61
            :|..|..:|.|.||...|:    ||.. |:|:......|:.|....|..:|..:|.....|..:.
Human    11 LSPPPAALPFLLLLWAGASRGQPCPGR-CICQNVAPTLTMLCAKTGLLFVPPAIDRRVVELRLTD 74

  Fly    62 NALQVLQSERFLRMDLLNLQKIYLSRNQLIRIHEKAFRGLTNLVELDLSENALQNVPSETFQDYS 126
            |.:..::...|..|  .:|..:.||||.:.::...||..|..|..|.|..|.|..|..:..:...
Human    75 NFIAAVRRRDFANM--TSLVHLTLSRNTIGQVAAGAFADLRALRALHLDSNRLAEVRGDQLRGLG 137

  Fly   127 SLMRLSLSGNPIRELKTSAFRHLSFLTT---LELSNCQVERIENEAFVGMDNLEWLRLDGNRIGF 188
            :|..|.|..|.||.::::||.  :||:|   |:||...:|.:..||...|.||..|.||.|.|..
Human   138 NLRHLILGNNQIRRVESAAFD--AFLSTVEDLDLSYNNLEALPWEAVGQMVNLNTLTLDHNLIDH 200

  Fly   189 I---------------------------------QGTHILPKSLHGISLHSNRWNCDCRLLDIHF 220
            |                                 |||...|.:...:|...|..:|:|.||
Human   201 IAEGTFVQLHKLVRLDMTSNRLHKLPPDGLFLRSQGTGPKPPTPLTVSFGGNPLHCNCELL---- 261

  Fly   221 WLVNYNTPLAEE---PKCMEPARLKGQVIKSLQREQLACLPEVSPQSS--YTEVSEGRNMSITCL 280
            ||    ..|..|   ..|..|..|..:...|:..|:..|.|.:..:.:  ...|.||:.:|:.|.
Human   262 WL----RRLTREDDLETCATPEHLTDRYFWSIPEEEFLCEPPLITRQAGGRALVVEGQAVSLRCR 322

  Fly   281 VRAIPEPKVLWLF-NGQVMSNDSLM----DNLHMYYYIDETIGVSGAEEKRSEIFIYNVGAEDNG 340
            ....|||.|.|:. :|:::.|.|..    |..     :|.||                ....|:|
Human   323 AVGDPEPVVHWVAPDGRLLGNSSRTRVRGDGT-----LDVTI----------------TTLRDSG 366

  Fly   341 TFSCVGQNIAGTTFSNYTLRVI----IKEPPVV---------NEVSFP-RDYMNYIVASSAGGGI 391
            ||:|:..|.||...:...:.|:    :..||..         ::::.| |...|...|...
Human   367 TFTCIASNAAGEATAPVEVCVVPLPLMAPPPAAPPPLTEPGSSDIATPGRPGANDSAAERR---- 427

  Fly   392 IFVVLLCTIVVKCKKTSE------PAKQRK----KCDQVTSIAGGTDS-------STGST---QD 436
                     :|..:.||.      || ||.    :..||...:...||       ||..|   .|
Human   428 ---------LVAAELTSNSVLIRWPA-QRPVPGIRMYQVQYNSSVDDSLVYRMIPSTSQTFLVND 482

  Fly   437 TGMGM---MKCASILNDGGDSM-------------NGNP-------GLLLGDTLTPTKAANGAAG 478
            ...|.   :...::.:||..::             .|:|       ...||.|:.       .|.
Human   483 LAAGRAYDLCVLAVYDDGATALPATRVVGCVQFTTAGDPAPCRPLRAHFLGGTMI-------IAI 540

  Fly   479 GGIILGNQMKQNLLL------YATPNSAQ----------QQLQLNVNLMGTGPGSPPLLLSNGHG 527
            ||:|:.:.:...:||      |...:|.:          ..:....|..|||....|.|.:..|.
Human   541 GGVIVASVLVFIVLLMIRYKVYGDGDSRRVKGSRSLPRVSHVCSQTNGAGTGAAQAPALPAQDHY 605

  Fly   528 LAAAYCSPPASLRNYQ-EKNPDLVNDAESVKHKLKTAV-------SLDGAG-------EYETQSD 577
            .|         ||..: :..|.:..:|::::.:..:|.       ||.|:.       ..||..:
Human   606 EA---------LREVESQAAPAVAVEAKAMEAETASAEPEVVLGRSLGGSATSLCLLPSEETSGE 661

  Fly   578 CGQYEGCYQLAAAPHPHQ---GHQHPHPGHPLMGRFAQAMTTLPRGMQLKPAPHQVDVHLNPVCF 639
                    :..||..|.:   |...|....|      ..:..:|.|...:|.|.
Human   662 --------ESRAAVGPRRSRSGALEPPTSAP------PTLALVPGGAAARPRPQ----------- 701

  Fly   640 LGQDGSFAYDYSSAHMVQQPPQQQQQQQQVQPANNFYRTLPHNRLHKQQQFQAAAAAGGNVGVGG 704
              |..||..||.:.......|::.::.::       :|:.||          ...|.||..|..|
Human   702 --QRYSFDGDYGALFQSHSYPRRARRTKR-------HRSTPH----------LDGAGGGAAGEDG 747

  Fly   705 N 705
            :
Human   748 D 748

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek2	NP_523551.1	leucine-rich repeat	34..52	CDD:275380	4/17 (24%)
		leucine-rich repeat	54..79	CDD:275380	4/24 (17%)
		LRR_8	79..138	CDD:290566	18/58 (31%)
		LRR_RI	<80..187	CDD:238064	38/109 (35%)
		leucine-rich repeat	80..103	CDD:275380	8/22 (36%)
		leucine-rich repeat	104..127	CDD:275380	6/22 (27%)
		LRR_8	126..186	CDD:290566	24/62 (39%)
		leucine-rich repeat	128..151	CDD:275380	8/22 (36%)
		leucine-rich repeat	152..175	CDD:275380	9/25 (36%)
		leucine-rich repeat	176..198	CDD:275380	11/54 (20%)
		TPKR_C2	207..256	CDD:301599	14/51 (27%)
		I-set	258..361	CDD:254352	26/109 (24%)
		Ig_2	263..361	CDD:290606	25/104 (24%)
LRFN1	NP_065913.1	LRR_RI	<65..174	CDD:238064	32/112 (29%)
		LRR_8	65..125	CDD:290566	16/61 (26%)
		LRR 1	66..87		3/20 (15%)
		leucine-rich repeat	67..90	CDD:275380	4/24 (17%)
		LRR 2	90..111		7/20 (35%)
		leucine-rich repeat	91..114	CDD:275380	8/22 (36%)
		LRR_8	113..174	CDD:290566	20/62 (32%)
		LRR 3	114..135		6/20 (30%)
		leucine-rich repeat	115..138	CDD:275380	6/22 (27%)
		LRR 4	138..159		8/22 (36%)
		leucine-rich repeat	139..163	CDD:275380	10/25 (40%)
		LRR_8	162..222	CDD:290566	16/59 (27%)
		LRR 5	163..184		7/20 (35%)
		leucine-rich repeat	164..187	CDD:275380	7/22 (32%)
		LRR_4	165..203	CDD:289563	15/37 (41%)
		LRR 6	187..208		8/20 (40%)
		leucine-rich repeat	188..211	CDD:275380	7/22 (32%)
		LRR 7	211..232		0/20 (0%)
		leucine-rich repeat	212..230	CDD:275380	0/17 (0%)
		LRRCT	252..>284	CDD:214507	12/39 (31%)
		IG_like	310..385	CDD:214653	25/95 (26%)
		Ig	314..387	CDD:299845	23/93 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	397..422		4/24 (17%)
		fn3	426..500	CDD:278470	16/87 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	654..743		24/132 (18%)
		PDZ-binding	768..771
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm41933
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910