DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment kek2 and ISLR2

DIOPT Version :9

Sequence 1:NP_523551.1 Gene:kek2 / 34582 FlyBaseID:FBgn0015400 Length:894 Species:Drosophila melanogaster
Sequence 2:NP_001123608.1 Gene:ISLR2 / 57611 HGNCID:29286 Length:745 Species:Homo sapiens


Alignment Length:832 Identity:174/832 - (20%)
Similarity:281/832 - (33%) Gaps:246/832 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 IWIPLLALLAITAACPPEVCVCKWKGGKQTVECGGQQLSNLPEGMDPGTQVLNFSGNALQVLQSE 70
            :|: :.|||.:..:| ||.|.|..|...|..:|..::|..:|||:......|:.|.|.:.||:..
Human     7 LWL-VWALLGVAGSC-PEPCACVDKYAHQFADCAYKELREVPEGLPANVTTLSLSANKITVLRRG 69

  Fly    71 RFLRMDLLNLQKIYLSRNQLIRIHEKAFRGLTNLVELDLSENALQNVPSETFQDYSSLMRLSLSG 135
            .|  .|:..:..::|:.|::..:...|...|:.|..||||.|.:.:.|      :|.|       
Human    70 AF--ADVTQVTSLWLAHNEVRTVEPGALAVLSQLKNLDLSHNFISSFP------WSDL------- 119

  Fly   136 NPIRELKTSAFRHLSFLTTLELSNCQVERIENEAFVGMDNLEWLRLDGNRIGFI-QGTHILPKSL 199
                       |:||.|..|::::.::..:..:|...:.:|..||::.||:..: .||.....:|
Human   120 -----------RNLSALQLLKMNHNRLGSLPRDALGALPDLRSLRINNNRLRTLAPGTFDALSAL 173

  Fly   200 HGISLHSNRWNCDCRLLDIHFWLVNYNTPLAEEPK--CMEPARLKGQVIKSLQREQLACLP---- 258
            ..:.|:.|.::|.|.|:.:..|..:....|.|...  |..|..|:|..:..|  ..|.|.|    
Human   174 SHLQLYHNPFHCGCGLVWLQAWAASTRVSLPEPDSIACASPPALQGVPVYRL--PALPCAPPSVH 236

  Fly   259 ---EVSPQSSYTEVSEGRNMSITCLVRAIPEPKVLW---LFNGQVMSNDSLMDNLHMYYYIDETI 317
               |...::..|.:..|....:.|:....|.|::.|   :..|.|:....::..        |..
Human   237 LSAEPPLEAPGTPLRAGLAFVLHCIADGHPTPRLQWQLQIPGGTVVLEPPVLSG--------EDD 293

  Fly   318 GVSGAEEKRSE------------------------------------IFIYNVGAEDNGTFSCVG 346
            || ||||...|                                    :.:..:.|::.|.::|..
Human   294 GV-GAEEGEGEGDGDLLTQTQAQTPTPAPAWPAPPATPRFLALANGSLLVPLLSAKEAGVYTCRA 357

  Fly   347 QNIAGTTFSNYTLRVIIKEPPVVNEVSFPRDYMNYIVASSAGGGIIFVVLLCTIVVKCKKTSEPA 411
            .|..|...::..:.|....||.              .|..|||.              .....|.
Human   358 HNELGANSTSIRVAVAATGPPK--------------HAPGAGGE--------------PDGQAPT 394

  Fly   412 KQRKKCDQ---------------------VTSIAGGTDSSTGSTQDTGMGMMKCASILNDGGDSM 455
            .:||...:                     ..||.|.|:  |...:||..|......||.|..:..
Human   395 SERKSTAKGRGNSVLPSKPEGKIKGQGLAKVSILGETE--TEPEEDTSEGEEAEDQILADPAEEQ 457

  Fly   456 ---NGNP----------------------GLLLGDT--------LTPTKA----ANGAAGGGIIL 483
               ||:|                      |::..|.        |||..|    ..|.|||....
Human   458 RCGNGDPSRYVSNHAFNQSAELKPHVFELGVIALDVAEREARVQLTPLAARWGPGPGGAGGAPRP 522

  Fly   484 GNQMKQNLLLYATP---NSAQQ--QLQLNVN---LMGTGPGSPPLLLSNGHGLAAAYCSPPASLR 540
            |.:..:  |||..|   .:|.|  :::..||   ..|..||:.   .|....||...|.......
Human   523 GRRPLR--LLYLCPAGGGAAVQWSRVEEGVNAYWFRGLRPGTN---YSVCLALAGEACHVQVVFS 582

  Fly   541 NYQEKNPDLVNDAESVKHKLKTAVSLDGAGEYETQSDCGQYEGCYQLAAAP-HPHQGHQHPHPGH 604
            ..:|....||..|.||...:...|.|.||.       |     |:.||..| .|::....|....
Human   583 TKKELPSLLVIVAVSVFLLVLATVPLLGAA-------C-----CHLLAKHPGKPYRLILRPQAPD 635

  Fly   605 PLMGRFAQAMTTLPRGMQLK-----PAPHQVDVHLNPVCFLGQDGSFAYDYSSAHMVQQPPQQQ- 663
            |:..|.|....  ||...|:     ||.             |:.|.           ::|...| 
Human   636 PMEKRIAADFD--PRASYLESEKSYPAG-------------GEAGG-----------EEPEDVQG 674

  Fly   664 ----QQQQQVQPANNFYR--------TLPHNRLHKQQQFQAAAAAGGNVGVG 703
                :..:|..|:.:..|        .:.......|::|:|.:.....:.:|
Human   675 EGLDEDAEQGDPSGDLQREESLAACSLVESQSKANQEEFEAGSEYSDRLPLG 726

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kek2NP_523551.1 leucine-rich repeat 34..52 CDD:275380 6/17 (35%)
leucine-rich repeat 54..79 CDD:275380 7/24 (29%)
LRR_8 79..138 CDD:290566 13/58 (22%)
LRR_RI <80..187 CDD:238064 24/106 (23%)
leucine-rich repeat 80..103 CDD:275380 4/22 (18%)
leucine-rich repeat 104..127 CDD:275380 7/22 (32%)
LRR_8 126..186 CDD:290566 12/59 (20%)
leucine-rich repeat 128..151 CDD:275380 3/22 (14%)
leucine-rich repeat 152..175 CDD:275380 3/22 (14%)
leucine-rich repeat 176..198 CDD:275380 7/22 (32%)
TPKR_C2 207..256 CDD:301599 13/50 (26%)
I-set 258..361 CDD:254352 23/148 (16%)
Ig_2 263..361 CDD:290606 21/136 (15%)
ISLR2NP_001123608.1 leucine-rich repeat 36..52 CDD:275380 5/15 (33%)
LRR_8 52..109 CDD:404697 16/58 (28%)
LRR 1 52..73 6/22 (27%)
leucine-rich repeat 53..76 CDD:275380 7/24 (29%)
LRR 2 76..97 3/20 (15%)
leucine-rich repeat 77..100 CDD:275380 4/22 (18%)
LRR_8 99..159 CDD:404697 19/83 (23%)
LRR 3 100..123 10/46 (22%)
leucine-rich repeat 101..124 CDD:275380 11/46 (24%)
LRR 4 124..145 3/20 (15%)
leucine-rich repeat 125..148 CDD:275380 3/22 (14%)
LRR 5 148..169 7/20 (35%)
leucine-rich repeat 149..172 CDD:275380 7/22 (32%)
PCC 154..>228 CDD:188093 18/75 (24%)
Ig_3 232..359 CDD:404760 21/135 (16%)
Ig strand B 256..263 CDD:409353 1/6 (17%)
Ig strand C 269..274 CDD:409353 1/4 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 287..326 8/47 (17%)
Ig strand C' 305..307 CDD:409353 0/1 (0%)
Ig strand D 331..335 CDD:409353 0/3 (0%)
Ig strand E 338..343 CDD:409353 0/4 (0%)
Ig strand F 351..359 CDD:409353 2/7 (29%)
Ig strand G 362..372 CDD:409353 1/9 (11%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 375..466 23/120 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 656..722 12/89 (13%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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