DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kek2 and lrfn2b

DIOPT Version :9

Sequence 1:	NP_523551.1	Gene:	kek2 / 34582	FlyBaseID:	FBgn0015400	Length:	894	Species:	Drosophila melanogaster
Sequence 2:	XP_009292765.1	Gene:	lrfn2b / 558484	ZFINID:	ZDB-GENE-121214-111	Length:	781	Species:	Danio rerio

Alignment Length:	777	Identity:	161/777 - (20%)
Similarity:	270/777 - (34%)	Gaps:	205/777 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LLALLAITAACPPEVCVCKWKGGKQTVECGGQQLSNLPEGMDPGTQVLNFSGNALQVLQSERFLR 74
            :|.::|:.|...|:.|.|:.........|..:.|..:|..:|..|..|...||.:..:..:.|..
Zfish    10 VLGMVAVMARACPKYCACQNLSESLGTLCPAKGLLFVPSDIDRSTVELRLGGNFILRITQQDFAN 74

  Fly    75 M----------------------DLLNLQKIYLSRNQLIRIHEKAFRGLTNLVELDLSENALQNV 117
            |                      ||..|:.:::..|:|..:.....|||.:|..|.|:.|.|..|
Zfish    75 MTDLVDLTLSRNTISYIQPFSFGDLETLRSLHMDNNRLTELGPDDLRGLISLQHLILNNNQLSRV 139

  Fly   118 PSETFQDYSSLMR-LSLSGNPIRELKTSAFRHLSFLTTLELSNCQVERIENEAFVGMDNLEWLRL 181
            ....|:|.::.:. |.||.|.::.|...:.|.:..|..|.|.:..::.|....||.::.|..|.|
Zfish   140 SERAFEDLAATLEDLDLSYNNLQALPWHSVRQMINLHQLSLDHNLLDYIPEGTFVDLERLARLDL 204

  Fly   182 DGNRI--------------GFIQGTHILPKSLHGISLHSNRWNCDCRLLDIHFWLVNYNTPLAEE 232
            ..||:              ..:..|...|:.  .:|:..|..:|:|.||    |....... .:.
Zfish   205 TSNRLQKLPPDPIFARAQDSEVMTTPFAPQL--SLSIGGNPLHCNCELL----WFRRLERD-DDL 262

  Fly   233 PKCMEPARLKGQVIKSLQREQLACLPEVSPQSSYTEVS-EGRNMSITCLVRAIPEPKVLWLFNGQ 296
            ..|..|..|||:...:::..:..|...:..|.::..:: ||:..|:.|.....|.|.:.|
Zfish   263 ETCASPPGLKGRYFWNVREHEFLCEQPLITQHTHKLLALEGQTASLRCDAIGDPIPTIHW----- 322

  Fly   297 VMSNDSLMDNLHMYYYIDETIGVSGAEEKRSEIFIYNVG--------AEDNGTFSCVGQNIAGTT 353
            |...|.|:.|                   .|...:|..|        ::|:|||:|:..|:||.:
Zfish   323 VTPEDRLLGN-------------------SSRTVVYRNGTLEILITTSKDSGTFTCIAANLAGES 368

  Fly   354 FSNYTLRVIIKEPPVVN---EVSFPRDYMNYIVASS-AGGGI----------IFVVLLCTIVVK- 403
            .::..|. ||:.|.:.|   :.|.|:..::.|...| ...||          :..|.....:|:
Zfish   369 TASVELS-IIQLPHISNGTGQASQPKSRLSDITGGSRTNKGIPKGQPEKAVSVSEVTAVAALVRW 432

  Fly   404 -CKKTSEPAK--------------------QRKKCDQVTSIAGGT-----------DSSTGSTQD 436
             ..||:...|                    ...|...:|::..||           ||:|..|..
Zfish   433 TVGKTAPKVKMFQLQYNCSDDEVLIYRMIPSSSKAFHITNLVSGTRYDLCVLAAWEDSATTLTAT 497

  Fly   437 TGMGMM---------KCASILNDGGDSMNGNPGLLLGDTLTPT------------KAANGAAGGG 480
            ..:|.:         :|.|:   .|..:.|...|::|..:..|            ||.:   |||
Zfish   498 NVVGCVEFYTRDDYTQCQSL---QGQLLGGTMILVVGGVIVATLLVFIVILMVRYKAGD---GGG 556

  Fly   481 IILGNQMKQNLLLYATPNSAQQQLQLNVNLMGTGPGSPPLL--------------------LSNG 525
            ....:::..:...|:..|..:.. |..|.|.|....|...:                    .|:|
Zfish   557 DAPVSKLSDSSETYSQTNGGRLG-QNGVPLPGPKEKSTVTMRDEVVKFKCGSLQSSSSSSSSSSG 620

  Fly   526 HGLAAAYCSPPASLRNYQEKNPDLVNDAESVKHKLKTAVSLDGAGEYETQSDCGQYEGCYQLAAA 590
            ...|.:| ||.::|.|.....|.  ....::...|....||:..|  :::..|  ..|....|||
Zfish   621 SADATSY-SPNSALANILRSAPP--KQHNNIDQLLGAFTSLELRG--QSKDLC--LSGTPSSAAA 678

  Fly   591 PHPHQGHQHPHPGHPLMGR-----------------------FAQAMTTLPRGMQLKPAPHQ 629
            |.....  .|....||:||                       |.....|:|...||:..|.:
Zfish   679 PAVSPA--GPADKEPLLGRTLDSRLSKLLMLPLDSKPKRSHSFDMGDFTVPTAQQLRSYPRR 738

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek2	NP_523551.1	leucine-rich repeat	34..52	CDD:275380	3/17 (18%)
		leucine-rich repeat	54..79	CDD:275380	8/46 (17%)
		LRR_8	79..138	CDD:290566	18/59 (31%)
		LRR_RI	<80..187	CDD:238064	31/121 (26%)
		leucine-rich repeat	80..103	CDD:275380	6/22 (27%)
		leucine-rich repeat	104..127	CDD:275380	8/22 (36%)
		LRR_8	126..186	CDD:290566	16/60 (27%)
		leucine-rich repeat	128..151	CDD:275380	6/23 (26%)
		leucine-rich repeat	152..175	CDD:275380	6/22 (27%)
		leucine-rich repeat	176..198	CDD:275380	7/35 (20%)
		TPKR_C2	207..256	CDD:301599	11/48 (23%)
		I-set	258..361	CDD:254352	24/111 (22%)
		Ig_2	263..361	CDD:290606	24/106 (23%)
lrfn2b	XP_009292765.1	LRR_RI	27..>209	CDD:238064	43/181 (24%)
		LRR_8	52..112	CDD:290566	10/59 (17%)
		leucine-rich repeat	54..77	CDD:275380	6/22 (27%)
		leucine-rich repeat	78..101	CDD:275380	2/22 (9%)
		LRR_8	101..161	CDD:290566	18/59 (31%)
		LRR_4	102..141	CDD:289563	12/38 (32%)
		leucine-rich repeat	102..125	CDD:275380	6/22 (27%)
		leucine-rich repeat	126..149	CDD:275380	8/22 (36%)
		LRR_8	150..209	CDD:290566	16/58 (28%)
		leucine-rich repeat	151..174	CDD:275380	6/22 (27%)
		leucine-rich repeat	175..198	CDD:275380	6/22 (27%)
		leucine-rich repeat	235..246	CDD:275378	2/12 (17%)
		LRRCT	242..>274	CDD:214507	10/36 (28%)
		I-set	289..376	CDD:254352	24/111 (22%)
		Ig	303..376	CDD:299845	22/97 (23%)
		fn3	418..485	CDD:278470	9/66 (14%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm6336
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910