DRSC/TRiP Functional Genomics Resources

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Protein Alignment kek2 and LRRN3

DIOPT Version :9

Sequence 1:NP_523551.1 Gene:kek2 / 34582 FlyBaseID:FBgn0015400 Length:894 Species:Drosophila melanogaster
Sequence 2:NP_001093128.1 Gene:LRRN3 / 54674 HGNCID:17200 Length:708 Species:Homo sapiens


Alignment Length:707 Identity:151/707 - (21%)
Similarity:242/707 - (34%) Gaps:266/707 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MSGLPIWIPLLALLAITAA---------CPPEVCVCK---WKGGK------QTVECGGQQLSNLP 47
            |..:|:.|.:|..||||..         | |.:|.|:   |...:      .||:|....|...|
Human     1 MKDMPLRIHVLLGLAITTLVQAVDKKVDC-PRLCTCEIRPWFTPRSIYMEASTVDCNDLGLLTFP 64

  Fly    48 EGMDPGTQVL------------------NFSG--------------------NALQVLQSERFLR 74
            ..:...||:|                  |.:|                    ..|.|...|..|.
Human    65 ARLPANTQILLLQTNNIAKIEYSTDFPVNLTGLDLSQNNLSSVTNINVKKMPQLLSVYLEENKLT 129

  Fly    75 -------MDLLNLQKIYLSRNQLIRIHEKAFRGLTNLVELDLSENALQNVPSETFQDYSSLMRLS 132
                   .:|.|||::|::.|.|..|...||.||.||:.|.|:.|.||.:.|:.|....:|..|.
Human   130 ELPEKCLSELSNLQELYINHNLLSTISPGAFIGLHNLLRLHLNSNRLQMINSKWFDALPNLEILM 194

  Fly   133 LSGNPIRELKTSAFRHLSFLTTLELSNCQVERIENEAFVGMDNLEWLRLDGNRIGFIQGTHI--- 194
            :..|||..:|...|:.|..|.:|.::...:..|.:.|.||::|||.:....||:  |:..|:   
Human   195 IGENPIIRIKDMNFKPLINLRSLVIAGINLTEIPDNALVGLENLESISFYDNRL--IKVPHVALQ 257

  Fly   195 ----------------------------------------------------------------- 194
                                                                             
Human   258 KVVNLKFLDLNKNPINRIRRGDFSNMLHLKELGINNMPELISIDSLAVDNLPDLRKIEATNNPRL 322

  Fly   195 ----------LPK--SL-----------HG----------ISLHSNRWNCDC--RLLDIHFWLVN 224
                      |||  ||           ||          ||:|||...|||  |.::::...:.
Human   323 SYIHPNAFFRLPKLESLMLNSNALSALYHGTIESLPNLKEISIHSNPIRCDCVIRWMNMNKTNIR 387

  Fly   225 YNTPLAEEPKCMEPARLKGQVIKSLQ-REQL-ACLPEVSPQS--SYTEVSEGRNMSITCLVRAIP 285
            :..|  :...|::|...:||.::.:. |:.: .|||.::|:|  |...|..|..:|..|...|.|
Human   388 FMEP--DSLFCVDPPEFQGQNVRQVHFRDMMEICLPLIAPESFPSNLNVEAGSYVSFHCRATAEP 450

  Fly   286 EPKVLWLF-NGQVMSNDSLMDNLHMYYYIDETIGVSGAEEKRSEIFIYNVGAEDNGTFSCVGQNI 349
            :|::.|:. :||.:..::|.|.  .|.:.:.|:.::|...|            :.|.::|:..|:
Human   451 QPEIYWITPSGQKLLPNTLTDK--FYVHSEGTLDINGVTPK------------EGGLYTCIATNL 501

  Fly   350 AGTTFSNYTLRVIIKEPPVVNEVSFPRD------------YMNYIVAS-SAGGGIIFVVLLCTIV 401
            .|....:..::|         :.|||:|            ..|.::.| .|...|:...:..|..
Human   502 VGADLKSVMIKV---------DGSFPQDNNGSLNIKIRDIQANSVLVSWKASSKILKSSVKWTAF 557

  Fly   402 VKCKKTS-------------------EPA--------------KQRKKCDQVTSIAGGTDSSTGS 433
            ||.:.:.                   .|:              |.||||..||:.....|.....
Human   558 VKTENSHAAQSARIPSDVKVYNLTHLNPSTEYKICIDIPTIYQKNRKKCVNVTTKGLHPDQKEYE 622

  Fly   434 TQDTG------------MGMMKCASILN-----DGGDSMNGN----PGLLLGDTLTP 469
            ..:|.            :|::...|.|:     |||.|...|    |...||:...|
Human   623 KNNTTTLMACLGGLLGIIGVICLISCLSPEMNCDGGHSYVRNYLQKPTFALGELYPP 679

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kek2NP_523551.1 leucine-rich repeat 34..52 CDD:275380 5/17 (29%)
leucine-rich repeat 54..79 CDD:275380 10/69 (14%)
LRR_8 79..138 CDD:290566 23/58 (40%)
LRR_RI <80..187 CDD:238064 38/106 (36%)
leucine-rich repeat 80..103 CDD:275380 10/22 (45%)
leucine-rich repeat 104..127 CDD:275380 8/22 (36%)
LRR_8 126..186 CDD:290566 18/59 (31%)
leucine-rich repeat 128..151 CDD:275380 8/22 (36%)
leucine-rich repeat 152..175 CDD:275380 6/22 (27%)
leucine-rich repeat 176..198 CDD:275380 9/101 (9%)
TPKR_C2 207..256 CDD:301599 11/52 (21%)
I-set 258..361 CDD:254352 24/105 (23%)
Ig_2 263..361 CDD:290606 22/100 (22%)
LRRN3NP_001093128.1 LRRNT 28..72 CDD:214470 10/44 (23%)
LRR 1 70..91 3/20 (15%)
leucine-rich repeat 72..93 CDD:275380 2/20 (10%)
LRR <75..355 CDD:227223 55/281 (20%)
LRR 2 93..114 2/20 (10%)
leucine-rich repeat 94..117 CDD:275380 1/22 (5%)
LRR 3 117..138 4/20 (20%)
leucine-rich repeat 118..141 CDD:275380 5/22 (23%)
LRR 4 141..162 9/20 (45%)
leucine-rich repeat 142..165 CDD:275380 10/22 (45%)
LRR 5 165..186 9/20 (45%)
leucine-rich repeat 166..189 CDD:275380 8/22 (36%)
LRR 6 189..210 7/20 (35%)
leucine-rich repeat 190..213 CDD:275380 8/22 (36%)
LRR 7 213..234 4/20 (20%)
leucine-rich repeat 214..237 CDD:275380 6/22 (27%)
LRR 8 237..258 7/22 (32%)
leucine-rich repeat 238..261 CDD:275380 6/24 (25%)
LRR 9 261..282 0/20 (0%)
leucine-rich repeat 262..285 CDD:275380 0/22 (0%)
LRR 10 285..304 0/18 (0%)
leucine-rich repeat 286..310 CDD:275380 0/23 (0%)
LRR 11 310..332 0/21 (0%)
leucine-rich repeat 311..333 CDD:275380 0/21 (0%)
LRR 12 335..358 5/22 (23%)
leucine-rich repeat 336..359 CDD:275380 4/22 (18%)
PCC 341..>442 CDD:188093 25/102 (25%)
Ig 437..513 CDD:325142 19/89 (21%)
fn3 526..593 CDD:306538 8/66 (12%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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