Protein Alignment kek2 and islr2

DIOPT Version :10

• Sequence 1: NP_523551.1
• Gene: kek2 / 34582
• FlyBaseID: FBgn0015400
• Length: 894
• Species: Drosophila melanogaster
• Sequence 2: NP_001013541.1
• Gene: islr2 / 541396
• ZFINID: ZDB-GENE-050320-95
• Length: 712
• Species: Danio rerio
• Alignment Length: 588
• Identity: 127/588 - (21%)
• Similarity: 225/588 - (38%)
• Gaps: 139/588 - (23%)

  Fly     7 WIPLLAL---LAITAACPPEVCVCKWKGGKQTVECGGQQLSNLPEGMDPGTQVLNFSGNALQVLQ 68
            ::.|:||   |...|.|.|:.|.|..|...|.|:|..:.|..:|.|:......|:.|.|.::||:
Zfish     5 YLMLIALGTALIGNAHCCPKQCACSDKYNHQFVDCAYKDLVEVPVGLPSNASTLSLSANKIKVLK 69

  Fly    69 SERFLRMDLLNLQKIYLSRNQLIRIHEKAFRGLTNLVELDLSENALQNVPSETFQDYSSLMRLSL 133
            |:.|  :::..:..::|:.|::|.:.......|..|..||:|.|.:.:.|.|...:..:|..|.:
Zfish    70 SKTF--VNVTQVTSLWLAHNEIITVERDTLAPLIQLKNLDISNNKIVHFPWEDLANLGALQLLKM 132

  Fly   134 SGNPIRELKTSAFRHLSFLTTLELSNCQVERIENEAFVGMDNLEWLRLDGNRIGFIQGTHILPKS 198
            :.|.:..:..:||.:|..|.::        ||.|..|..:               :|||.....:
Zfish   133 NNNEMVSIPKNAFSNLKDLRSI--------RINNNKFTTI---------------VQGTFDSLAA 174

  Fly   199 LHGISLHSNRWNCDCRLLDIHFWLVNYNTPLAEEPK--CMEPARLKGQVIKSLQREQLAC-LPEV 260
            :..:.:..|.:.|.|.|..:..|::..:..:.|:..  |..|:.|||..:.|:.:  |.| .|.|
Zfish   175 MSHLQIFHNPFICSCNLEWLRDWILKSSISIPEQNNIACDAPSHLKGSQVTSMPK--LNCKAPSV 237

  Fly   261 S----PQSSYTEVSEGRNMSITCLVRAIPEPKVLWLFNGQVMSNDSLMDNLHMYYYIDET-IGVS 320
            |    |....||:.||..:.:.|..:..|:|:|.|    ::.:.:.|: ...:...:::: |.::
Zfish   238 SITYQPNIEKTELYEGYMVMLYCETKGTPKPEVTW----EIFAGNQLI-TFPLPAIVEKSDIPIN 297

  Fly   321 GAEE-------KRSEIFIYNVGAEDNGTFSCVGQNIAGTTFSNYTLRVIIKEPPVVNEV------ 372
            |...       :...:.:..:..::.|.::|...|..|...|:..|.|...:....|.:
Zfish   298 GPPTNTRFLVFQNGTLIVPRMSKKEEGNYTCSAVNDIGKAESSVRLVVAGTKKHATNSMLDTKSP 362

  Fly   373 -SFPRDYMNYIVASSAGGGIIFVVLLCTIVVKCKKTSEPAKQRKKCDQVTSIAGGTDSSTGSTQD 436
             ..|.|.:.                     .|..|.|..:.:.|..::..|:..||...|...:.
Zfish   363 GLLPEDKLG---------------------SKGSKNSVISMRPKFEEKTKSLPTGTSVITVDKEQ 406

  Fly   437 TGMG------MMKCASILNDGGDSMN------------------GNPGLLLGDT-----LTPTKA 472
            ...|      :.||.  :|||...::                  |...|.:.:|     |.|.:.
Zfish   407 VDEGADTLPFVGKCG--INDGTQYISNHAFNLSLDELKQYTFDFGVIALEVSETEAKVQLNPMQM 469

  Fly   473 ANGAAGGGIILGNQMKQNLLLYATPNSAQQQLQLNVN-----LMGTGPGSPPLLL-------SNG 525
            ||.            |.|:.|     |.||.|| .||     |..|.....||.|       .||
Zfish   470 ANA------------KSNIHL-----SQQQDLQ-TVNKEPFSLFQTSAKKSPLDLLYLCVSTGNG 516

  Fly   526 HGL 528
            |.:
Zfish   517 HSV 519

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kek2	NP_523551.1	LRR	<34..>204	CDD:443914	38/169 (22%)
		leucine-rich repeat	34..52	CDD:275380	6/17 (35%)
		leucine-rich repeat	54..79	CDD:275380	7/24 (29%)
		leucine-rich repeat	80..103	CDD:275380	4/22 (18%)
		leucine-rich repeat	104..127	CDD:275380	7/22 (32%)
		leucine-rich repeat	128..151	CDD:275380	6/22 (27%)
		leucine-rich repeat	152..175	CDD:275380	5/22 (23%)
		leucine-rich repeat	176..198	CDD:275380	3/21 (14%)
		LRRCT	207..256	CDD:214507	13/50 (26%)
		Ig_3	258..348	CDD:464046	18/101 (18%)
islr2	NP_001013541.1	LRR	<35..>182	CDD:443914	38/171 (22%)
		leucine-rich repeat	35..53	CDD:275380	6/17 (35%)
		leucine-rich repeat	57..78	CDD:275380	7/22 (32%)
		leucine-rich repeat	79..102	CDD:275380	4/22 (18%)
		leucine-rich repeat	103..126	CDD:275380	7/22 (32%)
		leucine-rich repeat	127..150	CDD:275380	6/22 (27%)
		leucine-rich repeat	151..174	CDD:275380	8/45 (18%)
		LRRCT	183..>221	CDD:214507	9/37 (24%)
		Ig	240..345	CDD:472250	19/109 (17%)
		Ig strand B	256..260	CDD:409405	0/3 (0%)
		Ig strand C	269..273	CDD:409405	2/7 (29%)
		Ig strand E	312..315	CDD:409405	0/2 (0%)
		Ig strand F	325..330	CDD:409405	1/4 (25%)
		Ig strand G	338..341	CDD:409405	1/2 (50%)