Protein Alignment kek2 and Lingo4

DIOPT Version :10

• Sequence 1: NP_523551.1
• Gene: kek2 / 34582
• FlyBaseID: FBgn0015400
• Length: 894
• Species: Drosophila melanogaster
• Sequence 2: NP_001102659.1
• Gene: Lingo4 / 499668
• RGDID: 1562025
• Length: 618
• Species: Rattus norvegicus
• Alignment Length: 525
• Identity: 119/525 - (22%)
• Similarity: 173/525 - (32%)
• Gaps: 193/525 - (36%)

  Fly     6 IWIPLLALLAI----TAACPPEVCVCKWKGGKQTVECGGQQLSNLPEGMDPGTQVLNFSGNALQV 66
            :|.|||.||.:    .::||   .:|......:.|.|..::|..:|.|:...|:||:.|||.|..
  Rat    38 LWSPLLFLLLLPGGSISSCP---TLCDCTSQTRAVLCAHRRLDTVPGGLPLDTEVLDLSGNRLWG 99

  Fly    67 LQSERFLRMDLLNLQKIYLSRNQLIRIHEKAFRGLTNLVELDLSENALQNVPSETFQDYSSLMRL 131
            ||.....|:.  .||::.||.|||..:...||.||.:|:.|.|..|.|:.|....|...|:|..|
  Rat   100 LQRGMLSRLG--QLQELDLSYNQLSTLEPGAFHGLQSLLTLRLQGNRLRIVGPGIFSGLSALTLL 162

  Fly   132 SLSGNPI--------------RELKT----------SAFRHLSFLTTLELSNC------------ 160
            .|..|.|              ::|:.          .||..|:.|:|:.|..|
  Rat   163 DLRLNQIVLFLDGAFGELGSLQQLEVGDNHLVFVAPGAFSGLAKLSTITLERCNLSTVPGLALAQ 227

  Fly   161 ------------QVERIENEAFVGMDNLE------WLRLD----GNRIG---------------- 187
                        .:||:.:.|..|:..|:      |..|:    |:.:|
  Rat   228 LPALVALRLRELDIERLPSGALRGLGQLKELEIHHWPSLEALDPGSLVGLNLSSLAITHCNLSSV 292

  Fly   188 ---------FIQG--------------------------------THILPKSLHGIS-------- 203
                     |:|.                                |.|...:.||::
  Rat   293 PFQALHHLSFLQVLDLSQNPISAIPARRLSPLVRLQELRLSGACLTSIAAHAFHGLTAFHLLDVA 357

  Fly   204 ----------------------LHSNRWNCDCRLLDIHFWLVNYNTPL---AEEPKCMEPARLKG 243
                                  |..|...||||||    ||:.....|   ...|.|..|..::|
  Rat   358 DNALQTLEETAFPSPDKLVTLRLSGNPLTCDCRLL----WLLRLRRRLDFGTSPPACAGPQHVQG 418

  Fly   244 QVIKS----LQREQLACLPEVSPQSS--YTEVSEGRNMSITCLVRAIPEPKVLWL-----FNGQV 297
            :.::.    |......|.|.:..:|.  :....||.:...:|.....|.|.|.|:     :.|:|
  Rat   419 KNLREFSDILPPGHFTCKPALIRKSGPRWVIAEEGGHAVFSCSGDGDPAPTVSWMRPQGSWLGRV 483

  Fly   298 MSNDSLMDNLHMYYYIDETIGVSGAEEKRSEIFIYNVGAEDNGTFSCVGQNIAGTTFSNYTLRVI 362
            .....|.|               |..|.||      |...|.|.:.||..|:||.......|.||
  Rat   484 GRVRVLED---------------GTLEIRS------VQLRDRGAYVCVVSNVAGNDSLRTWLEVI 527

  Fly   363 IKEPP 367
            ..|||
  Rat   528 QVEPP 532

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kek2	NP_523551.1	LRR	<34..>204	CDD:443914	62/314 (20%)
		leucine-rich repeat	34..52	CDD:275380	5/17 (29%)
		leucine-rich repeat	54..79	CDD:275380	10/24 (42%)
		leucine-rich repeat	80..103	CDD:275380	11/22 (50%)
		leucine-rich repeat	104..127	CDD:275380	7/22 (32%)
		leucine-rich repeat	128..151	CDD:275380	9/46 (20%)
		leucine-rich repeat	152..175	CDD:275380	8/46 (17%)
		leucine-rich repeat	176..198	CDD:275380	9/88 (10%)
		LRRCT	207..256	CDD:214507	15/55 (27%)
		Ig_3	258..348	CDD:464046	22/96 (23%)
Lingo4	NP_001102659.1	leucine-rich repeat	87..110	CDD:275380	10/24 (42%)
		LRR	<88..441	CDD:443914	74/358 (21%)
		leucine-rich repeat	111..134	CDD:275380	11/22 (50%)
		leucine-rich repeat	135..158	CDD:275380	7/22 (32%)
		leucine-rich repeat	159..182	CDD:275380	5/22 (23%)
		leucine-rich repeat	183..206	CDD:275380	4/22 (18%)
		leucine-rich repeat	207..230	CDD:275380	4/22 (18%)
		leucine-rich repeat	231..254	CDD:275380	4/22 (18%)
		leucine-rich repeat	255..302	CDD:275380	5/46 (11%)
		leucine-rich repeat	303..326	CDD:275380	1/22 (5%)
		leucine-rich repeat	327..348	CDD:275380	3/20 (15%)
		leucine-rich repeat	351..374	CDD:275380	0/22 (0%)
		IG_like	445..526	CDD:214653	24/101 (24%)
		Ig strand B	456..460	CDD:409353	0/3 (0%)
		Ig strand C	469..473	CDD:409353	1/3 (33%)
		Ig strand E	492..496	CDD:409353	1/3 (33%)
		Ig strand F	506..511	CDD:409353	1/4 (25%)
		Ig strand G	519..522	CDD:409353	0/2 (0%)