DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek2 and vasn

DIOPT Version :9

Sequence 1:	NP_523551.1	Gene:	kek2 / 34582	FlyBaseID:	FBgn0015400	Length:	894	Species:	Drosophila melanogaster
Sequence 2:	NP_001005036.1	Gene:	vasn / 448556	XenbaseID:	XB-GENE-941552	Length:	661	Species:	Xenopus tropicalis

Alignment Length:	365	Identity:	94/365 - (25%)
Similarity:	136/365 - (37%)	Gaps:	107/365 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LPIWIPLLALL--AITAACPPEVCVCKWKGGKQTVECGGQQLSNLPEGMDPGTQVLNFSGNALQV 66
            |.:||.|||..  .||..||.. |.|   ...|||.|..::.||.|..:.|.|..|....|.:..
Frog     4 LLVWIILLATAQQMITEGCPAG-CQC---NTPQTVFCLARKNSNFPRSVPPDTLNLYVFENGISS 64

  Fly    67 LQSERFLRMDLLNLQKIYLSRNQLIRIHEKAFRGLTNLVELDLSENALQNVPSETFQDYSSLMRL 131
            ::...|:.::.|:|  :.||.|||..:....||.|.||..|||:.|.|..:.::|||..|.|.||
Frog    65 IEESSFIGLNGLHL--LDLSHNQLSSLPGGVFRNLANLSNLDLTSNQLTEISADTFQGLSRLERL 127

  Fly   132 SLSGNPIRELKTSAFRHLSFLTTLELSNCQ----------------------------------- 161
            .|:||.||.:...||:.:..|..|:|||.|
Frog   128 YLNGNRIRSIHPEAFKGIESLLELKLSNNQLVTPPAFSLPHLLLLDLSYNAIPVIQQGVFNAGNI 192

  Fly   162 ---------VERIENEAFVGMDNLEWLRLDGNR-------------------IGFIQ-------- 190
                     ::.:..|...|:.||..|.|..|:                   :||.|
Frog   193 ESLRLAGLGLKEVPEELLSGLKNLHELDLSDNQLDKVPPGLHGLTKLNIAGNVGFSQIQVDDLSN 257

  Fly   191 ------------GTHILPKS-------LHGISLHSNRWNCDCRLLDIHFWLVNYNTPL--AEEPK 234
                        ....|||.       |..:||..|.:||.|.|..:..|:......|  .:|.:
Frog   258 LPALQELDLSGLSLQTLPKGLFRSSKRLRAVSLAQNPFNCVCSLGWLSEWMRVSGVVLLRPDETR 322

  Fly   235 CMEPARLKGQVIKSLQREQLAC-------LPEVSPQSSYT 267
            |..|.:..|:.::.|:..:..|       :|...|.|:.|
Frog   323 CHFPPKNAGKTLRQLRDSEYGCPAPTTIQMPSTMPPSTTT 362

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek2	NP_523551.1	leucine-rich repeat	34..52	CDD:275380	7/17 (41%)
		leucine-rich repeat	54..79	CDD:275380	4/24 (17%)
		LRR_8	79..138	CDD:290566	26/58 (45%)
		LRR_RI	<80..187	CDD:238064	43/169 (25%)
		leucine-rich repeat	80..103	CDD:275380	9/22 (41%)
		leucine-rich repeat	104..127	CDD:275380	9/22 (41%)
		LRR_8	126..186	CDD:290566	24/122 (20%)
		leucine-rich repeat	128..151	CDD:275380	10/22 (45%)
		leucine-rich repeat	152..175	CDD:275380	8/66 (12%)
		leucine-rich repeat	176..198	CDD:275380	9/60 (15%)
		TPKR_C2	207..256	CDD:301599	12/50 (24%)
		I-set	258..361	CDD:254352	4/10 (40%)
		Ig_2	263..361	CDD:290606	2/5 (40%)
vasn	NP_001005036.1	LRRNT	21..52	CDD:214470	12/34 (35%)
		leucine-rich repeat	52..75	CDD:275380	4/22 (18%)
		LRR 1	52..72		4/19 (21%)
		LRR	<60..>276	CDD:227223	50/217 (23%)
		LRR 2	75..96		8/22 (36%)
		leucine-rich repeat	76..99	CDD:275380	10/24 (42%)
		LRR_8	99..158	CDD:338972	26/58 (45%)
		LRR 3	99..120		9/20 (45%)
		leucine-rich repeat	100..123	CDD:275380	9/22 (41%)
		LRR 4	123..144		10/20 (50%)
		leucine-rich repeat	124..147	CDD:275380	10/22 (45%)
		LRR 5	147..168		6/20 (30%)
		leucine-rich repeat	148..169	CDD:275380	6/20 (30%)
		LRR 6	169..189		0/19 (0%)
		leucine-rich repeat	170..191	CDD:275380	0/20 (0%)
		LRR 7	191..212		1/20 (5%)
		leucine-rich repeat	192..215	CDD:275380	2/22 (9%)
		LRR 8	215..237		5/21 (24%)
		leucine-rich repeat	216..235	CDD:275380	4/18 (22%)
		leucine-rich repeat	236..260	CDD:275380	3/23 (13%)
		LRR 9	238..258		3/19 (16%)
		LRR 10	259..281		3/21 (14%)
		leucine-rich repeat	261..281	CDD:275380	3/19 (16%)
		PCC	265..>344	CDD:188093	18/78 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	348..395		4/15 (27%)
		EGF	407..438	CDD:333761
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	591..661
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	124	1.000	Inparanoid score	I4567
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm49155
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.960