DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kek2 and LRRC24

DIOPT Version :9

Sequence 1:	NP_523551.1	Gene:	kek2 / 34582	FlyBaseID:	FBgn0015400	Length:	894	Species:	Drosophila melanogaster
Sequence 2:	NP_001019849.2	Gene:	LRRC24 / 441381	HGNCID:	28947	Length:	513	Species:	Homo sapiens

Alignment Length:	456	Identity:	120/456 - (26%)
Similarity:	185/456 - (40%)	Gaps:	71/456 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 PIWIP-LLALLAITAACPPEVCVCKWKGGKQTVECGGQQLSNLPEGMDPGTQVLNFSGNALQVLQ 68
            |..:| ||.||.:.||..|..|.|.    ..|||||..:|..:|.|:.||||.|        .||
Human     6 PALLPLLLLLLPLRAAGCPAACRCY----SATVECGALRLRVVPLGIPPGTQTL--------FLQ 58

  Fly    69 SERFLRMD------LLNLQKIYLSRNQLIRIHEKAFRGLTNLVELDLSENALQNVPSETFQDYSS 127
            .....|::      |..|:::||..|.|..:...|||....|:||.|:.|.|:.:.|..|...:.
Human    59 DNNIARLEPGALAPLAALRRLYLHNNSLRALEAGAFRAQPRLLELALTSNRLRGLRSGAFVGLAQ 123

  Fly   128 LMRLSLSGNPIRELKTSAFRHLSFLTTLELSNCQVERIENEAFVGMDNLEWLRLDGNRIGFIQGT 192
            |..|.|:||.:..|....|.||..|..|.|....:|.:|::|..|:.:|..|.|..|::|.|...
Human   124 LRVLYLAGNQLARLLDFTFLHLPRLQELHLQENSIELLEDQALAGLSSLALLDLSRNQLGTISRE 188

  Fly   193 HILP-KSLHGISLHSNRWNCDCRLLDIHFWLVNYNTPL--AEEPK--CMEPARLKGQVIKSLQRE 252
            .:.| .||..:.|..|.|.|||.|..:..|:......|  :.:.|  |.||.||..|.:..:...
Human   189 ALQPLASLQVLRLTENPWRCDCALHWLGAWIKEGGQRLLTSRDRKIMCAEPPRLALQSLLDVSHS 253

  Fly   253 QLACL-PEVSPQSSYTEVSEGRNMSITCLVRAIPEPKVLWL-----FNGQVMSNDSLMDNLHMYY 311
            .|.|: |.|..|......:.|.::.:.|.....|:|.|.|.     ..|:..:...|...|
Human   254 SLICIPPSVHVQPLELTANLGEDLRVACQASGYPQPLVTWRKVPQPREGRPRAQAQLEGGL---- 314

  Fly   312 YIDETIGVSG---AEEKRSEIFIYNVGAEDNGTFSCVGQNIAGTTFSNYTLRVIIK--------- 364
                 :|:.|   ::.....:|:.|:.....|.:.|...|..|.  :....|:::.
Human   315 -----LGLGGHSASDTGSGMLFLSNITLAHAGKYECEASNAGGA--ARVPFRLLVNASRQQPQQP 372

  Fly   365 ---EPPVVNEV-SFPRDYMNYI----------VASSAGGGIIFVVLLCTIVVKCKKTSEPAKQRK 415
               .||..... |.||.....:          .|.:|...::.:..|..:.:.|::    .::||
Human   373 AQPPPPAARPAGSEPRPEAGSMAFRALGVATQTAIAAAIALLALTALLLVAMICRR----RRRRK 433

  Fly   416 K 416
            |
Human   434 K 434

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek2	NP_523551.1	leucine-rich repeat	34..52	CDD:275380	8/17 (47%)
		leucine-rich repeat	54..79	CDD:275380	7/30 (23%)
		LRR_8	79..138	CDD:290566	21/58 (36%)
		LRR_RI	<80..187	CDD:238064	36/106 (34%)
		leucine-rich repeat	80..103	CDD:275380	8/22 (36%)
		leucine-rich repeat	104..127	CDD:275380	8/22 (36%)
		LRR_8	126..186	CDD:290566	20/59 (34%)
		leucine-rich repeat	128..151	CDD:275380	9/22 (41%)
		leucine-rich repeat	152..175	CDD:275380	7/22 (32%)
		leucine-rich repeat	176..198	CDD:275380	7/22 (32%)
		TPKR_C2	207..256	CDD:301599	16/52 (31%)
		I-set	258..361	CDD:254352	20/110 (18%)
		Ig_2	263..361	CDD:290606	18/105 (17%)
LRRC24	NP_001019849.2	LRR_RI	49..>158	CDD:238064	37/116 (32%)
		LRR_8	<50..86	CDD:290566	13/43 (30%)
		LRR 1	51..72		7/28 (25%)
		leucine-rich repeat	53..75	CDD:275380	6/29 (21%)
		LRR 2	75..96		7/20 (35%)
		LRR_8	76..134	CDD:290566	21/57 (37%)
		leucine-rich repeat	76..99	CDD:275380	8/22 (36%)
		LRR 3	99..120		8/20 (40%)
		leucine-rich repeat	100..123	CDD:275380	8/22 (36%)
		LRR_8	123..205	CDD:290566	26/81 (32%)
		LRR 4	123..144		7/20 (35%)
		leucine-rich repeat	124..147	CDD:275380	9/22 (41%)
		LRR 5	147..168		6/20 (30%)
		leucine-rich repeat	148..171	CDD:275380	7/22 (32%)
		LRR 6	171..192		6/20 (30%)
		leucine-rich repeat	172..195	CDD:275380	7/22 (32%)
		LRRCT	204..257	CDD:214507	16/52 (31%)
		Ig	259..364	CDD:299845	21/115 (18%)
		IG_like	266..362	CDD:214653	18/106 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	365..391		5/25 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	3	2.870