DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek2 and kek6

DIOPT Version :9

Sequence 1:	NP_523551.1	Gene:	kek2 / 34582	FlyBaseID:	FBgn0015400	Length:	894	Species:	Drosophila melanogaster
Sequence 2:	NP_001263151.1	Gene:	kek6 / 43729	FlyBaseID:	FBgn0039862	Length:	843	Species:	Drosophila melanogaster

Alignment Length:	895	Identity:	225/895 - (25%)
Similarity:	356/895 - (39%)	Gaps:	208/895 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LPI-WIPLLALLAITAA------CPPEVCVCKWKGGKQTVECGGQQLSNLPEGMDPGTQVLNFSG 61
            ||: || ||.|:|.|.|      |... |.|||..||::..|...||:.:|..:....|||..:.
  Fly    16 LPVCWI-LLCLVAWTVADDWSLSCASN-CTCKWTNGKKSAICSSLQLTTIPNTLSTELQVLVLND 78

  Fly    62 NALQVLQSERFLRMDLLNLQKIYLSRNQLIRIHEKAFRGLTNLVELDLSENALQNVPSETFQDYS 126
            |.:..|..|.|..:.|||||:|||.::::..||:::||.|..|||:|||:|.|:.:..:||....
  Fly    79 NHIPYLNREEFSTLGLLNLQRIYLKKSEVQYIHKESFRNLKILVEIDLSDNKLEMLDKDTFMGND 143

  Fly   127 SLMRLSLSGNPIRELKTSAFRHLSFLTTLELSNCQVERIENEAFVGMDNLEWLRLDGNRIGFIQG 191
            .|..|.|:|||::.|....|..|..|.||::.:|.:..|:..:...::.||:|.|..|.:..:..
  Fly   144 RLRILYLNGNPLKRLAAYQFPILPHLRTLDMHDCLISYIDPMSLANLNLLEFLNLKNNLLESLSE 208

  Fly   192 ---THILPKSLHGISLHSNRWNCDCRLLDIHFWLVNYNTPLAEEPKCMEPARLKGQVIKSLQREQ 253
               .|:  .:|..:||..|.|.|:|:|.....|.||.... :....|..|...|.:...|:..|.
  Fly   209 YVFQHM--ANLKTLSLEENPWQCNCKLRKFRGWYVNSRLS-SVSLVCKGPPAQKDRTWDSVDDEL 270

  Fly   254 LACLP--EVSPQSSYTEVSEGRNMSITCLVRAIPEPKVLWLFNGQVMSNDSLMDNLHMYYYIDET 316
            ..|.|  |:........:..|.|.:.:|||...|.|:|.|..||:::.||:::       :..|:
  Fly   271 FGCPPRVEIFNNEEVQNIDIGSNTTFSCLVYGDPLPEVAWELNGKILDNDNVL-------FESES 328

  Fly   317 IGVSGAEEKRSEIFIYNVGAEDNGTFSCVGQNIAGTTFSNYTLRVIIKEPPVVNEV--SFPRDYM 379
            |   .:::..|.:.::||.:.|.||::|.|.|..|:...|  :.:.:.|  :|..|  ..|..:.
  Fly   329 I---ASDKLWSNLTVFNVTSLDAGTYACTGSNSIGSMTQN--ISIYLSE--IVQHVLEKTPETFW 386

  Fly   380 NYIVASSAGGGIIFVVLLCTIVVKCKKTSEPAKQRKKCDQVTSIAGGTDSSTGSTQDTGMGMMKC 444
            .:.:.....|.:..::.:..:|..||:|:...:...|       ||...|.:.:.|:..:.....
  Fly   387 YFGLIMGIFGTVFLLISISFVVCLCKRTTRQHRHANK-------AGVKSSVSFNDQEKKLLDSSV 444

  Fly   445 ASILNDGGDS--MNGNP---GLLLGDTLTPTKAANGAAGGGIILGNQMKQNLLLYATPNSAQQQL 504
            .:..||.|||  ::..|   |:..||          :||.|.   ||::    ::|..
  Fly   445 TTTTNDRGDSYGIDNQPTSIGMNKGD----------SAGMGF---NQIE----IHAVE------- 485

  Fly   505 QLNVNLMGTGPGSPPLLLSNGHGLAAAYCSPPASLRNYQEKNPDLVNDAESVKHKLKTAVSLDGA 569
                              |:.||          |:...|:.....|.....::.:|...
  Fly   486 ------------------SHRHG----------SMLVQQQPQQQQVAGGGGMRQQLMQV------ 516

  Fly   570 GEYETQSDCGQYEGCYQLAAAPHPHQGHQHPHPGHPLMGRFAQAMTTLPRGMQLKPAPHQVDVHL 634
                ..|.||       :.:.|....||.|.||        ||.....|..:.:.|.|.:...::
  Fly   517 ----KDSTCG-------MMSVPTSMAGHAHSHP--------AQISEEFPLNVGVFPPPPEFCSNI 562

  Fly   635 NPVCFLGQDGSFAYDYSSAHMVQQPPQQQQQQQQVQPAN-NFYRTLPHNRLHKQQQFQAAAAAGG 698
            .|....|  |:.....|..            |..:..|: |.|..| .|...:.|..|.:.|...
  Fly   563 VPNPAFG--GNIFIRVSVT------------QDMLDGADLNMYPDL-LNIPKRMQDVQESGAGAV 612

  Fly   699 NVGVGGNPTL-RYSLEAEFIQRGPTVSYEKYQLPNVRFTAEGYPQQQQQQQQQLQQQQQLQLQQQ 762
            .|..|...|| |::.....:::..::..::.|      ..:.:..||||||||:||||..|||||
  Fly   613 AVPEGQFATLPRHTARRGILKKDTSLQQQQQQ------HQQQHQHQQQQQQQQIQQQQHQQLQQQ 671

  Fly   763 HQ-------------------FPSPPEGYKSDLAVMPAPFQQWPSCLPGYRFAQSPTSLPAVATP 808
            ||                   :.....||.|:...:|.|                         |
  Fly   672 HQPSGLYTHDEIVTYNLEASGYDPHQSGYHSNAMELPPP-------------------------P 711

  Fly   809 PPAAVVA------------------TPPPPTSAVSTQSTATSTIPELDES 840
            ||.||.|                  .||||::..|.....|...| ||.|
  Fly   712 PPPAVTAVVQCHHPSPNNCASCINNAPPPPSACQSPPVEVTPMRP-LDSS 760

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek2	NP_523551.1	leucine-rich repeat	34..52	CDD:275380	4/17 (24%)
		leucine-rich repeat	54..79	CDD:275380	8/24 (33%)
		LRR_8	79..138	CDD:290566	26/58 (45%)
		LRR_RI	<80..187	CDD:238064	39/106 (37%)
		leucine-rich repeat	80..103	CDD:275380	10/22 (45%)
		leucine-rich repeat	104..127	CDD:275380	10/22 (45%)
		LRR_8	126..186	CDD:290566	19/59 (32%)
		leucine-rich repeat	128..151	CDD:275380	9/22 (41%)
		leucine-rich repeat	152..175	CDD:275380	5/22 (23%)
		leucine-rich repeat	176..198	CDD:275380	6/24 (25%)
		TPKR_C2	207..256	CDD:301599	13/48 (27%)
		I-set	258..361	CDD:254352	28/104 (27%)
		Ig_2	263..361	CDD:290606	26/97 (27%)
kek6	NP_001263151.1	leucine-rich repeat	71..96	CDD:275380	8/24 (33%)
		LRR_8	96..155	CDD:290566	26/58 (45%)
		leucine-rich repeat	97..120	CDD:275380	10/22 (45%)
		leucine-rich repeat	121..144	CDD:275380	10/22 (45%)
		LRR_4	144..186	CDD:289563	14/41 (34%)
		leucine-rich repeat	145..168	CDD:275380	9/22 (41%)
		leucine-rich repeat	169..216	CDD:275380	11/48 (23%)
		LRRCT	225..274	CDD:214507	13/49 (27%)
		Ig	295..367	CDD:143165	24/83 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005302
OrthoInspector	1	1.000	-	-		mtm8422
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24366
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	4.010