DRSC/TRiP Functional Genomics Resources

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Protein Alignment kek2 and AMIGO3

DIOPT Version :9

Sequence 1:NP_523551.1 Gene:kek2 / 34582 FlyBaseID:FBgn0015400 Length:894 Species:Drosophila melanogaster
Sequence 2:NP_942015.1 Gene:AMIGO3 / 386724 HGNCID:24075 Length:504 Species:Homo sapiens


Alignment Length:523 Identity:112/523 - (21%)
Similarity:189/523 - (36%) Gaps:104/523 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MSGLPIWIPLLALLAITAACP-------------PEVCVCKWKGGKQTVECGGQQLSNLPEGMDP 52
            |:.|.:...||.:|.:....|             |..|:|    ....:.|.|..|.::|..:..
Human     1 MTWLVLLGTLLCMLRVGLGTPDSEGFPPRALHNCPYKCIC----AADLLSCTGLGLQDVPAELPA 61

  Fly    53 GTQVLNFSGNALQVLQSERFLRMDLLNLQKIYLSRNQLIRIHEKAFRGLTNLVELDLSENALQNV 117
            .|..|:.|.||||.|:....  ..|..|:.::|..|:|..:....|...:.|..||||.|.|:.:
Human    62 ATADLDLSHNALQRLRPGWL--APLFQLRALHLDHNELDALGRGVFVNASGLRLLDLSSNTLRAL 124

  Fly   118 PSETFQDYSSLMRLSLSGNPIRELKTSAFRHLSFLTTLELSNCQVERIENEAFVGMDNLEWLRLD 182
            .........:|.:|.|..|.:..|...||..|..|:.|.|...::.....:...|:.....|.||
Human   125 GRHDLDGLGALEKLLLFNNRLVHLDEHAFHGLRALSHLYLGCNELASFSFDHLHGLSATHLLTLD 189

  Fly   183 --GNRIGFIQGTHI--LPKSL-HGISLHSNRWNCDCRLLDI----HFWLVNYNTPLAEEPKCMEP 238
              .||:|.|....:  ||..| :|:.||:|...|||||..:    |...::.....|.|..|: .
Human   190 LSSNRLGHISVPELAALPAFLKNGLYLHNNPLPCDCRLYHLLQRWHQRGLSAVRDFAREYVCL-A 253

  Fly   239 ARLKGQVIKSLQR----EQLACLP----EVSPQSSYTEVSEGRNMSITCLVRAIPEPKVLWLFNG 295
            .::....::..|.    |..:..|    |...:..|..|  ||::.:.|.. ::|..::.|:...
Human   254 FKVPASRVRFFQHSRVFENCSSAPALGLERPEEHLYALV--GRSLRLYCNT-SVPAMRIAWVSPQ 315

  Fly   296 QVM-----SNDSLMDNLHMYYYIDETIGVSGAEEKRSEIFIYNVGAEDNGTFSCV--GQNIAGTT 353
            |.:     |.|..:..|     .|.::.:...:|:.:            |.|.|:  |..:....
Human   316 QELLRAPGSRDGSIAVL-----ADGSLAIGNVQEQHA------------GLFVCLATGPRLHHNQ 363

  Fly   354 FSNYTLRVIIKEPPVVNEVSFPR---DYMN--YIVASSAGGGIIFVVL--------LCTIVVKCK 405
            ...|.:           .|.|||   :..|  :........|::.|:|        .|....:|:
Human   364 THEYNV-----------SVHFPRPEPEAFNTGFTTLLGCAVGLVLVLLYLFAPPCRCCRRACRCR 417

  Fly   406 KTSEPAKQRKKCDQVTSIAGGTDSSTGSTQDTGMGMMKCASILNDGGDSMNG------------- 457
            :..:.....::....:|:...|.....|.:   ..:.|....|..|...:||             
Human   418 RWPQTPSPLQELSAQSSVLSTTPPDAPSRK---ASVHKHVVFLEPGRRGLNGRVQLAVAEEFDLY 479

  Fly   458 NPG 460
            |||
Human   480 NPG 482

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kek2NP_523551.1 leucine-rich repeat 34..52 CDD:275380 4/17 (24%)
leucine-rich repeat 54..79 CDD:275380 9/24 (38%)
LRR_8 79..138 CDD:290566 16/58 (28%)
LRR_RI <80..187 CDD:238064 29/108 (27%)
leucine-rich repeat 80..103 CDD:275380 5/22 (23%)
leucine-rich repeat 104..127 CDD:275380 7/22 (32%)
LRR_8 126..186 CDD:290566 16/61 (26%)
leucine-rich repeat 128..151 CDD:275380 8/22 (36%)
leucine-rich repeat 152..175 CDD:275380 4/22 (18%)
leucine-rich repeat 176..198 CDD:275380 9/25 (36%)
TPKR_C2 207..256 CDD:301599 12/56 (21%)
I-set 258..361 CDD:254352 20/113 (18%)
Ig_2 263..361 CDD:290606 18/104 (17%)
AMIGO3NP_942015.1 leucine-rich repeat 45..65 CDD:275380 5/19 (26%)
LRR 1 62..83 8/22 (36%)
LRR_8 <66..97 CDD:316378 11/32 (34%)
leucine-rich repeat 66..86 CDD:275380 8/21 (38%)
LRR_8 86..145 CDD:316378 16/58 (28%)
LRR 2 86..107 5/20 (25%)
leucine-rich repeat 87..110 CDD:275380 5/22 (23%)
LRR 3 110..133 7/22 (32%)
leucine-rich repeat 111..134 CDD:275380 7/22 (32%)
LRR 4 134..155 7/20 (35%)
LRR_8 135..195 CDD:316378 16/59 (27%)
leucine-rich repeat 135..158 CDD:275380 8/22 (36%)
LRR 5 158..178 3/19 (16%)
leucine-rich repeat 159..182 CDD:275380 4/22 (18%)
LRR 6 184..207 7/22 (32%)
leucine-rich repeat 185..208 CDD:275380 8/22 (36%)
IG_like 286..371 CDD:214653 18/115 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 422..448 3/28 (11%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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