Protein Alignment kek2 and AMIGO3

DIOPT Version :10

• Sequence 1: NP_523551.1
• Gene: kek2 / 34582
• FlyBaseID: FBgn0015400
• Length: 894
• Species: Drosophila melanogaster
• Sequence 2: NP_942015.1
• Gene: AMIGO3 / 386724
• HGNCID: 24075
• Length: 504
• Species: Homo sapiens
• Alignment Length: 523
• Identity: 112/523 - (21%)
• Similarity: 189/523 - (36%)
• Gaps: 104/523 - (19%)

  Fly     1 MSGLPIWIPLLALLAITAACP-------------PEVCVCKWKGGKQTVECGGQQLSNLPEGMDP 52
            |:.|.:...||.:|.:....|             |..|:|    ....:.|.|..|.::|..:..
Human     1 MTWLVLLGTLLCMLRVGLGTPDSEGFPPRALHNCPYKCIC----AADLLSCTGLGLQDVPAELPA 61

  Fly    53 GTQVLNFSGNALQVLQSERFLRMDLLNLQKIYLSRNQLIRIHEKAFRGLTNLVELDLSENALQNV 117
            .|..|:.|.||||.|:....  ..|..|:.::|..|:|..:....|...:.|..||||.|.|:.:
Human    62 ATADLDLSHNALQRLRPGWL--APLFQLRALHLDHNELDALGRGVFVNASGLRLLDLSSNTLRAL 124

  Fly   118 PSETFQDYSSLMRLSLSGNPIRELKTSAFRHLSFLTTLELSNCQVERIENEAFVGMDNLEWLRLD 182
            .........:|.:|.|..|.:..|...||..|..|:.|.|...::.....:...|:.....|.||
Human   125 GRHDLDGLGALEKLLLFNNRLVHLDEHAFHGLRALSHLYLGCNELASFSFDHLHGLSATHLLTLD 189

  Fly   183 --GNRIGFIQGTHI--LPKSL-HGISLHSNRWNCDCRLLDI----HFWLVNYNTPLAEEPKCMEP 238
              .||:|.|....:  ||..| :|:.||:|...|||||..:    |...::.....|.|..|: .
Human   190 LSSNRLGHISVPELAALPAFLKNGLYLHNNPLPCDCRLYHLLQRWHQRGLSAVRDFAREYVCL-A 253

  Fly   239 ARLKGQVIKSLQR----EQLACLP----EVSPQSSYTEVSEGRNMSITCLVRAIPEPKVLWLFNG 295
            .::....::..|.    |..:..|    |...:..|..|  ||::.:.|.. ::|..::.|:...
Human   254 FKVPASRVRFFQHSRVFENCSSAPALGLERPEEHLYALV--GRSLRLYCNT-SVPAMRIAWVSPQ 315

  Fly   296 QVM-----SNDSLMDNLHMYYYIDETIGVSGAEEKRSEIFIYNVGAEDNGTFSCV--GQNIAGTT 353
            |.:     |.|..:..|     .|.::.:...:|:.:            |.|.|:  |..:....
Human   316 QELLRAPGSRDGSIAVL-----ADGSLAIGNVQEQHA------------GLFVCLATGPRLHHNQ 363

  Fly   354 FSNYTLRVIIKEPPVVNEVSFPR---DYMN--YIVASSAGGGIIFVVL--------LCTIVVKCK 405
            ...|.:           .|.|||   :..|  :........|::.|:|        .|....:|:
Human   364 THEYNV-----------SVHFPRPEPEAFNTGFTTLLGCAVGLVLVLLYLFAPPCRCCRRACRCR 417

  Fly   406 KTSEPAKQRKKCDQVTSIAGGTDSSTGSTQDTGMGMMKCASILNDGGDSMNG------------- 457
            :..:.....::....:|:...|.....|.:   ..:.|....|..|...:||
Human   418 RWPQTPSPLQELSAQSSVLSTTPPDAPSRK---ASVHKHVVFLEPGRRGLNGRVQLAVAEEFDLY 479

  Fly   458 NPG 460
            |||
Human   480 NPG 482

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kek2	NP_523551.1	LRR	<34..>204	CDD:443914	48/174 (28%)
		leucine-rich repeat	34..52	CDD:275380	4/17 (24%)
		leucine-rich repeat	54..79	CDD:275380	9/24 (38%)
		leucine-rich repeat	80..103	CDD:275380	5/22 (23%)
		leucine-rich repeat	104..127	CDD:275380	7/22 (32%)
		leucine-rich repeat	128..151	CDD:275380	8/22 (36%)
		leucine-rich repeat	152..175	CDD:275380	4/22 (18%)
		leucine-rich repeat	176..198	CDD:275380	9/25 (36%)
		LRRCT	207..256	CDD:214507	12/56 (21%)
		Ig_3	258..348	CDD:464046	19/100 (19%)
AMIGO3	NP_942015.1	leucine-rich repeat	45..65	CDD:275380	5/19 (26%)
		LRR 1	62..83		8/22 (36%)
		LRR	<66..>221	CDD:443914	46/156 (29%)
		leucine-rich repeat	66..86	CDD:275380	8/21 (38%)
		LRR 2	86..107		5/20 (25%)
		leucine-rich repeat	87..110	CDD:275380	5/22 (23%)
		LRR 3	110..133		7/22 (32%)
		leucine-rich repeat	111..134	CDD:275380	7/22 (32%)
		LRR 4	134..155		7/20 (35%)
		leucine-rich repeat	135..158	CDD:275380	8/22 (36%)
		LRR 5	158..178		3/19 (16%)
		leucine-rich repeat	159..182	CDD:275380	4/22 (18%)
		LRR 6	184..207		7/22 (32%)
		leucine-rich repeat	185..208	CDD:275380	8/22 (36%)
		IG_like	286..371	CDD:214653	18/115 (16%)
		Ig strand B	296..300	CDD:409353	0/3 (0%)
		Ig strand C	308..312	CDD:409353	0/3 (0%)
		Ig strand E	335..339	CDD:409353	0/3 (0%)
		Ig strand F	349..354	CDD:409353	2/4 (50%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	422..448		3/28 (11%)