DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment kek2 and RTN4RL2

DIOPT Version :9

Sequence 1:NP_523551.1 Gene:kek2 / 34582 FlyBaseID:FBgn0015400 Length:894 Species:Drosophila melanogaster
Sequence 2:NP_848665.1 Gene:RTN4RL2 / 349667 HGNCID:23053 Length:420 Species:Homo sapiens


Alignment Length:302 Identity:82/302 - (27%)
Similarity:122/302 - (40%) Gaps:53/302 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly    10 LLALLAITAACP--PEVCVCKWKGGKQTVECGGQQLSNLPEGMDPGTQVLNFSGNALQVLQ---- 68
            ||.|||:..|.|  |.:|.|  .....||.|.....|::|..:.|.||.|....|.::.|:    
Human    18 LLMLLALPLAAPSCPMLCTC--YSSPPTVSCQANNFSSVPLSLPPSTQRLFLQNNLIRTLRPGTF 80

  Fly    69 ----------------------------------SERFLR-------MDLLNLQKIYLSRNQLIR 92
                                              ..|.||       ..|..||.::|.|.||..
Human    81 GSNLLTLWLFSNNLSTIYPGTFRHLQALEELDLGDNRHLRSLEPDTFQGLERLQSLHLYRCQLSS 145

  Fly    93 IHEKAFRGLTNLVELDLSENALQNVPSETFQDYSSLMRLSLSGNPIRELKTSAFRHLSFLTTLEL 157
            :....||||.:|..|.|.||:|.::..:.|.|.::|..|.|.||.:|.|....||.|..|..|.|
Human   146 LPGNIFRGLVSLQYLYLQENSLLHLQDDLFADLANLSHLFLHGNRLRLLTEHVFRGLGSLDRLLL 210

  Fly   158 SNCQVERIENEAFVGMDNLEWLRLDGNRIGFIQGTHI--LPKSLHGISLHSNRWNCDCRLLDIHF 220
            ...:::.:...||.|:..|..|.|..|.:..:.|..:  || ||..:.|::|.|.||||...:..
Human   211 HGNRLQGVHRAAFRGLSRLTILYLFNNSLASLPGEALADLP-SLEFLRLNANPWACDCRARPLWA 274

  Fly   221 WLVNYNTPLAEEPKCMEPARLKGQVIKSLQREQLACLPEVSP 262
            |....... :.:..|..|...:|:.:::|:.......|..:|
Human   275 WFQRARVS-SSDVTCATPPERQGRDLRALREADFQACPPAAP 315

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kek2NP_523551.1 leucine-rich repeat 34..52 CDD:275380 5/17 (29%)
leucine-rich repeat 54..79 CDD:275380 9/69 (13%)
LRR_8 79..138 CDD:290566 23/58 (40%)
LRR_RI <80..187 CDD:238064 38/106 (36%)
leucine-rich repeat 80..103 CDD:275380 10/22 (45%)
leucine-rich repeat 104..127 CDD:275380 8/22 (36%)
LRR_8 126..186 CDD:290566 20/59 (34%)
leucine-rich repeat 128..151 CDD:275380 10/22 (45%)
leucine-rich repeat 152..175 CDD:275380 6/22 (27%)
leucine-rich repeat 176..198 CDD:275380 7/23 (30%)
TPKR_C2 207..256 CDD:301599 11/48 (23%)
I-set 258..361 CDD:254352 2/5 (40%)
Ig_2 263..361 CDD:290606 82/302 (27%)
RTN4RL2NP_848665.1 LRR_8 60..117 CDD:290566 6/56 (11%)
leucine-rich repeat 62..83 CDD:275380 5/20 (25%)
leucine-rich repeat 84..107 CDD:275380 0/22 (0%)
LRR_RI 103..>261 CDD:238064 48/158 (30%)
LRR_8 108..167 CDD:290566 19/58 (33%)
leucine-rich repeat 108..132 CDD:275380 4/23 (17%)
leucine-rich repeat 133..156 CDD:275380 10/22 (45%)
LRR_8 156..215 CDD:290566 21/58 (36%)
leucine-rich repeat 157..180 CDD:275380 8/22 (36%)
leucine-rich repeat 181..204 CDD:275380 10/22 (45%)
LRR_8 204..262 CDD:290566 16/58 (28%)
leucine-rich repeat 205..228 CDD:275380 6/22 (27%)
leucine-rich repeat 229..252 CDD:275380 7/23 (30%)
TPKR_C2 261..311 CDD:301599 11/50 (22%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

Return to query results.
Submit another query.