DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment kek2 and CG18480

DIOPT Version :9

Sequence 1:NP_523551.1 Gene:kek2 / 34582 FlyBaseID:FBgn0015400 Length:894 Species:Drosophila melanogaster
Sequence 2:NP_001285960.1 Gene:CG18480 / 34920 FlyBaseID:FBgn0028518 Length:550 Species:Drosophila melanogaster


Alignment Length:378 Identity:83/378 - (21%)
Similarity:141/378 - (37%) Gaps:71/378 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 IWIPL--------LALLAITAACP---------PEVCVCKWKGGKQTVECGGQQLSNLPEGMDPG 53
            :|:.|        |.|..:...|.         |.||.|.....:....|..::|.:....:...
  Fly    11 MWLGLKQILLYVGLLLCVLLQVCRSKTQSQMFCPTVCHCDLHAQRNRAVCSAKRLISANIEIPTT 75

  Fly    54 TQVLNFSGNALQVLQSERF-LRMDLLNLQKIYLSRNQLIRIHEKAFRGLTNLVELDLSENALQNV 117
            .::|:.|.|.:..:..:.| ..:.||||.   |:.|.:..::..||..||.|..||||.|.|:.:
  Fly    76 VELLDLSYNDITTIDDDSFKTTIHLLNLT---LAHNAIHTLYGDAFVELTRLRYLDLSYNRLEQI 137

  Fly   118 PSETFQDYSSLMRLSLSGNPIRELKTSAFRHLSFLTTLELSNCQVERIENEAFVGMDNLEWLRLD 182
            .....:..:.|:.|:|.||.:..|..........|.:|.|.|.||.::..:....:..|..|.|.
  Fly   138 DEHILESNNQLIHLNLEGNKLSTLGKGPILRSPSLRSLNLRNSQVNQLGTQLLSALPQLRQLDLA 202

  Fly   183 GNRIGFIQ-GTHILPKSLHGISLHSNRWNCDCRLLDIHFWL------------------------ 222
            .|.:..:. |....|::|..:::..|.:|||..|..:...|                        
  Fly   203 QNLLLTLSPGDFHAPRNLASLNVEENPFNCDRALAKVATGLRQRGVAIFMSNCMEEEVQDHQDDA 267

  Fly   223 --VNY--NTPLAEEPKCMEPARLKGQVIKSLQREQLACLPEVSPQ-----SSYTEVSEGRNMSI- 277
              ||:  .....|..:.:||:....|.:.|:.|:..:...:.|.|     ||.::|.||....: 
  Fly   268 EAVNFPNKNEKFESMEYLEPSTRGPQSVLSVWRDLDSSEEQNSSQDDEQMSSLSDVCEGSREKLC 332

  Fly   278 ----TCLVRAIPEPKVLWLFNGQVMSNDSLM-------DNLHMYYYIDETIGV 319
                .||.|...|    .|..|.....|.::       |:|.:.:.:....||
  Fly   333 LRYRICLERVSHE----LLAGGNSQLEDEIIRTHTYDEDDLKLAFVVGGATGV 381

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kek2NP_523551.1 leucine-rich repeat 34..52 CDD:275380 2/17 (12%)
leucine-rich repeat 54..79 CDD:275380 5/25 (20%)
LRR_8 79..138 CDD:290566 20/58 (34%)
LRR_RI <80..187 CDD:238064 30/106 (28%)
leucine-rich repeat 80..103 CDD:275380 6/22 (27%)
leucine-rich repeat 104..127 CDD:275380 7/22 (32%)
LRR_8 126..186 CDD:290566 16/59 (27%)
leucine-rich repeat 128..151 CDD:275380 6/22 (27%)
leucine-rich repeat 152..175 CDD:275380 6/22 (27%)
leucine-rich repeat 176..198 CDD:275380 6/22 (27%)
TPKR_C2 207..256 CDD:301599 14/76 (18%)
I-set 258..361 CDD:254352 18/79 (23%)
Ig_2 263..361 CDD:290606 17/74 (23%)
CG18480NP_001285960.1 LRR_8 74..134 CDD:290566 20/62 (32%)
LRR_RI <76..230 CDD:238064 41/156 (26%)
leucine-rich repeat 76..99 CDD:275380 4/22 (18%)
leucine-rich repeat 100..123 CDD:275380 9/25 (36%)
LRR_8 122..182 CDD:290566 18/59 (31%)
leucine-rich repeat 124..147 CDD:275380 7/22 (32%)
leucine-rich repeat 148..171 CDD:275380 6/22 (27%)
LRR_8 170..230 CDD:290566 14/59 (24%)
leucine-rich repeat 172..195 CDD:275380 6/22 (27%)
leucine-rich repeat 196..219 CDD:275380 6/22 (27%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - P PTHR24366
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
22.010

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