DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek2 and kek3

DIOPT Version :9

Sequence 1:	NP_523551.1	Gene:	kek2 / 34582	FlyBaseID:	FBgn0015400	Length:	894	Species:	Drosophila melanogaster
Sequence 2:	NP_001162986.1	Gene:	kek3 / 34912	FlyBaseID:	FBgn0028370	Length:	1021	Species:	Drosophila melanogaster

Alignment Length:	1035	Identity:	258/1035 - (24%)
Similarity:	389/1035 - (37%)	Gaps:	257/1035 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LPIWIPLLALL--------AITAACPPEVCVCKWKGGKQTVECGGQQLSNLPEGMDPGTQVLNFS 60
            ||:.:.||..|        .:.|.| |.||.||||.||::|.|....|:::|:.:|.|||:|:.|
  Fly    55 LPLHLHLLLWLLCCCSQLGQLRAEC-PAVCECKWKSGKESVLCLNANLTHIPQPLDAGTQLLDLS 118

  Fly    61 GNALQVLQSERFLRMDLLNLQKIYLSRNQLIRIHEKAFRGLTNLVELDLSENALQNVPSETFQDY 125
            ||.:|::..:.|....||||||:||:|..|..|...|||.|.||||||||:|.|..:||......
  Fly   119 GNEIQLIPDDSFATAQLLNLQKVYLARCHLRLIERHAFRKLINLVELDLSQNLLSAIPSLALYHV 183

  Fly   126 SSLMRLSLSGNPIRELKTSAFRHLSFLTTLELSNCQVERIENEAFVGMD-NLEWLRLDGNRIGFI 189
            |.|..|.||||||..:...||.|:..|..||||:|::..|...||.|:: :||||:|||||:..:
  Fly   184 SELRELRLSGNPILRVPDDAFGHVPQLVKLELSDCRLSHIAVRAFAGLESSLEWLKLDGNRLSEV 248

  Fly   190 Q-GTHILPKSLHGISLHSNRWNCDCRLLDIHFWLVNYNTPLAEEPKCMEPARLKGQVIKSLQREQ 253
            : ||.....||||:.|..|.|||.|.|..:..|::..|.|....|.|..|.||.|:....|..:.
  Fly   249 RSGTITSLASLHGLELARNTWNCSCSLRPLRAWMLQQNIPSGIPPTCESPPRLSGRAWDKLDVDD 313

  Fly   254 LACLPEVSPQSSYTEVSEGRNMSITCLVRAIPEPKVLWLFNGQVMSN-------DSLMDNLHMYY 311
            .||:|::....:.....||||::::|.|..:|:|.|.||...::::|       ||
  Fly   314 FACVPQIVATDTTAHGVEGRNITMSCYVEGVPQPAVKWLLKNRLIANLSAGGDGDS--------- 369

  Fly   312 YIDETIGVSGAEEKR-----------SEIFIYNVGAEDNGTFSCVGQNIAGTTFSNYTLRVIIKE 365
              |.....:.|.:.|           |.:.|.....:|.|.::|..:|.||...::.|| .:.:.
  Fly   370 --DSEPRTAAATQGRKTYVVNMLRNASNLTILTADMQDAGIYTCAAENKAGKVEASVTL-AVSRR 431

  Fly   366 PPVVNEVSFPRDYMNYIVASSA-----GGGIIFVVLLCTIVVKCK----KTSEPAKQRKKCDQV- 420
            ||     ..|......::.:.|     ||.....:.||::..:.|    .:..|.::.:..:::
  Fly   432 PP-----EAPWGVRIILLGAVAALLLVGGSSFAAICLCSLQRRRKLRLWNSVPPVRRSESYEKIE 491

  Fly   421 ------TSIAGGTDSSTGSTQDTGMGMMKCA---SILNDGGDSMNGNPGLLLGDTLTPTKAANGA 476
                  ..:.||.....||.  ||.|:...|   ..|......:|.|........:.|:..:...
  Fly   492 MTARTRPDLGGGASCGGGSA--TGAGLFHDAEEQGYLRAAHTPLNDNDAGQAAAIVNPSAGSAQR 554

  Fly   477 AGGGII--------------LGNQMKQNLLLYATPNSAQQQLQLNVNLMGTGPGSPPLLLSNGHG 527
            ..|..:              |.:..:|.......|:..|||.|....             |.||.
  Fly   555 RNGDYLHVSTHCDDEEEDQQLHHHPQQQPASQHHPHPNQQQHQQRKG-------------SQGHV 606

  Fly   528 LAAAYCSPPASLRNYQEKNPDLVNDAESVKHKLKTAVSLDGAGEYETQSDCGQYEGCYQLAAAPH 592
            ::|:..:..|.|.......|.|::               .|..:..:.|...|.:...:||.
  Fly   607 VSASGANNSAPLEETDLHIPRLID---------------IGGTDSASSSISSQVDAAARLAG--- 653

  Fly   593 PHQGH------------QHPHPGHPLMGRFAQAMTTLPRGMQLKP----APHQVDVHLNPV-CFL 640
             :.||            ..|| ..|:......::.|     |..|    ..|..|.....| |..
  Fly   654 -YAGHTWKTTPIATTKINSPH-SKPVTSAAPSSLNT-----QATPYAHYGNHPADEMATSVFCSE 711

  Fly   641 GQDGS-FAYDYS-----SAHMVQQPPQQQQQQ---QQVQPANNFYRTLPHNRLHKQQQFQAAAAA 696
            ||:.. |..:|.     :.:.|.|..|:.:.|   |.....|....|||.......:.|:.::.:
  Fly   712 GQESDLFDSNYPDLLDIAKYAVAQAQQEGRGQGYAQATTTPNGGLCTLPRKLKTSGKYFRNSSDS 776

  Fly   697 -----GGNVGVGGNPTL--------------RYSLEAEFIQRGPTVSYEKYQLPNVRFTAEGYPQ 742
                 ..|....|:.||              |||.|:.:.....|.:|          |..|
  Fly   777 QSPLLADNSSKYGSSTLGDGSFLNEAMGLGRRYSAESSYANYSSTATY----------TGGG--- 828

  Fly   743 QQQQQQQQLQQQQQLQ-------LQQQHQFPSPPEGYKSDLAVMPAPFQQWPSCLPGYRFAQSPT 800
            |:......|.|....|       |.|:...||.|..::..|:....|...: |.|.......:.|
  Fly   829 QRANSFLNLVQSGAHQGKLLPSHLGQKPSLPSSPVQHQRSLSSAATPLLDF-SALASRAAGAANT 892

  Fly   801 SLPA----------------------------------------VATPPPAAVVATP-------- 817
            |:.|                                        ||....||.:|.|
  Fly   893 SVAAYDYHAAQLERFLEEYRNLQDQLCKMKETCDTIRKKETPLRVAIGQSAAQLADPVMYSAASH 957

  Fly   818 ---PPPTSAVSTQSTATSTIPELDESEASSPRLEEAAGSAAPPAGEEESSDTAKLKQLNG 874
               ||.||.:.|::......|:                  .||.....:   |.||:|||
  Fly   958 SPKPPATSNLKTKTLLPGQPPD------------------PPPYWLHRN---AMLKRLNG 996

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek2	NP_523551.1	leucine-rich repeat	34..52	CDD:275380	4/17 (24%)
		leucine-rich repeat	54..79	CDD:275380	9/24 (38%)
		LRR_8	79..138	CDD:290566	32/58 (55%)
		LRR_RI	<80..187	CDD:238064	55/107 (51%)
		leucine-rich repeat	80..103	CDD:275380	12/22 (55%)
		leucine-rich repeat	104..127	CDD:275380	11/22 (50%)
		LRR_8	126..186	CDD:290566	30/60 (50%)
		leucine-rich repeat	128..151	CDD:275380	11/22 (50%)
		leucine-rich repeat	152..175	CDD:275380	10/23 (43%)
		leucine-rich repeat	176..198	CDD:275380	11/22 (50%)
		TPKR_C2	207..256	CDD:301599	16/48 (33%)
		I-set	258..361	CDD:254352	28/120 (23%)
		Ig_2	263..361	CDD:290606	27/115 (23%)
kek3	NP_001162986.1	LRR_RI	<110..267	CDD:238064	74/156 (47%)
		leucine-rich repeat	112..137	CDD:275380	9/24 (38%)
		LRR_8	137..196	CDD:290566	32/58 (55%)
		leucine-rich repeat	138..161	CDD:275380	12/22 (55%)
		leucine-rich repeat	162..185	CDD:275380	11/22 (50%)
		LRR_8	184..245	CDD:290566	30/60 (50%)
		leucine-rich repeat	186..209	CDD:275380	11/22 (50%)
		leucine-rich repeat	210..234	CDD:275380	10/23 (43%)
		leucine-rich repeat	235..258	CDD:275380	11/22 (50%)
		LRRCT	267..316	CDD:214507	16/48 (33%)
		IG_like	328..428	CDD:214653	27/111 (24%)
		Ig	335..425	CDD:143165	21/100 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D23311at33392
OrthoFinder	1	1.000	-	-		FOG0005302
OrthoInspector	1	1.000	-	-		mtm8422
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24366
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	5.020