DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kek2 and AMIGO2

DIOPT Version :9

Sequence 1:	NP_523551.1	Gene:	kek2 / 34582	FlyBaseID:	FBgn0015400	Length:	894	Species:	Drosophila melanogaster
Sequence 2:	NP_001137140.1	Gene:	AMIGO2 / 347902	HGNCID:	24073	Length:	522	Species:	Homo sapiens

Alignment Length:	505	Identity:	125/505 - (24%)
Similarity:	199/505 - (39%)	Gaps:	79/505 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LLALLAIT--------AACPPEVCVCKWKGGKQTVECGGQQLSNLPEGMDPGTQVLNFSGNALQV 66
            ||.||.||        ..| |..|:|    ....|.|..:.||.:|..:....:.|:.|.|.:.:
Human    23 LLCLLMITVTVGPGASGVC-PTACIC----ATDIVSCTNKNLSKVPGNLFRLIKRLDLSYNRIGL 82

  Fly    67 LQSERFLRMDLLNLQKIYLSRNQLIRIHEKAFRGLTNLVELDLSENALQNVPSETFQDYSSLMRL 131
            |.|| ::.:....|..:.|..|.:..|...:|....||..||||.|.|:.|.:..||:...|..|
Human    83 LDSE-WIPVSFAKLNTLILRHNNITSISTGSFSTTPNLKCLDLSSNKLKTVKNAVFQELKVLEVL 146

  Fly   132 SLSGNPIRELKTSAFRHLSFLTTLELSNCQVERIENEAFVG---MDNLEWLRLDGNRIGFIQGTH 193
            .|..|.|..|..|||..||.|..|.||...:.:...:.:||   :..|.:|.:..|||..:...|
Human   147 LLYNNHISYLDPSAFGGLSQLQKLYLSGNFLTQFPMDLYVGRFKLAELMFLDVSYNRIPSMPMHH 211

  Fly   194 I--LP-KSLHGISLHSNRWNCDCRLLD-IHFWLVNYNTPLAE---EPKC--MEPARLKGQVIKSL 249
            |  :| |.|.||.||.|.:.|||.|.. :.||...:.:.:.:   :..|  ...:|...||: .|
Human   212 INLVPGKQLRGIYLHGNPFVCDCSLYSLLVFWYRRHFSSVMDFKNDYTCRLWSDSRHSRQVL-LL 275

  Fly   250 QREQLACLPEVSPQSSYT-----EVSEGRNMSITCLVRAIPEPKV-------LWLF-NGQVMSND 301
            |...:.|...:...|...     |...|..:.:.|      :.|.       :|:. :.:::..|
Human   276 QDSFMNCSDSIINGSFRALGFIHEAQVGERLMVHC------DSKTGNANTDFIWVGPDNRLLEPD 334

  Fly   302 SLMDNLHMYYYIDETIGVSGAEEKRSEIFIYNVGAEDNGTFSCVGQNIAGTTFSNYTLRVIIKEP 366
            ..|:|.::::              ...:.|.:...||.|.:||:..|  .....|.|:.|.|.
Human   335 KEMENFYVFH--------------NGSLVIESPRFEDAGVYSCIAMN--KQRLLNETVDVTIN-- 381

  Fly   367 PVVNEVSFPRDYMN------YIVASSAGGGIIFVVL---LCTIVVKCKKTSEPAKQRKKCDQVTS 422
              |:..:..|.:.:      :...::....|:.|:|   |.....|| ||........:.:..:|
Human   382 --VSNFTVSRSHAHEAFNTAFTTLAACVASIVLVLLYLYLTPCPCKC-KTKRQKNMLHQSNAHSS 443

  Fly   423 IAGGTDSSTGSTQDTGMGMMKCASILNDGGDSMNGNPGLLLGDTLTPTKA 472
            |.....:|..|..:...|..|....|....|:..|..|.:   .|.|::|
Human   444 ILSPGPASDASADERKAGAGKRVVFLEPLKDTAAGQNGKV---RLFPSEA 490

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek2	NP_523551.1	leucine-rich repeat	34..52	CDD:275380	5/17 (29%)
		leucine-rich repeat	54..79	CDD:275380	6/24 (25%)
		LRR_8	79..138	CDD:290566	20/58 (34%)
		LRR_RI	<80..187	CDD:238064	37/109 (34%)
		leucine-rich repeat	80..103	CDD:275380	5/22 (23%)
		leucine-rich repeat	104..127	CDD:275380	10/22 (45%)
		LRR_8	126..186	CDD:290566	20/62 (32%)
		leucine-rich repeat	128..151	CDD:275380	10/22 (45%)
		leucine-rich repeat	152..175	CDD:275380	6/25 (24%)
		leucine-rich repeat	176..198	CDD:275380	8/24 (33%)
		TPKR_C2	207..256	CDD:301599	13/54 (24%)
		I-set	258..361	CDD:254352	18/115 (16%)
		Ig_2	263..361	CDD:290606	18/110 (16%)
AMIGO2	NP_001137140.1	leucine-rich repeat	51..72	CDD:275380	5/20 (25%)
		LRR	<54..>240	CDD:227223	62/186 (33%)
		LRR 1	69..90		6/21 (29%)
		leucine-rich repeat	73..95	CDD:275380	6/22 (27%)
		LRR_8	94..175	CDD:338972	31/80 (39%)
		LRR 2	94..115		5/20 (25%)
		leucine-rich repeat	97..118	CDD:275380	4/20 (20%)
		LRR 3	118..139		10/20 (50%)
		leucine-rich repeat	119..142	CDD:275380	10/22 (45%)
		LRR 4	142..163		9/20 (45%)
		leucine-rich repeat	143..166	CDD:275380	10/22 (45%)
		LRR 5	166..187		4/20 (20%)
		leucine-rich repeat	167..193	CDD:275380	6/25 (24%)
		LRR 6	193..214		7/20 (35%)
		leucine-rich repeat	194..219	CDD:275380	8/24 (33%)
		TPKR_C2	228..283	CDD:387596	13/55 (24%)
		IG_like	298..380	CDD:214653	18/103 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	501..522
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910