DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek2 and kek4

DIOPT Version :9

Sequence 1:	NP_523551.1	Gene:	kek2 / 34582	FlyBaseID:	FBgn0015400	Length:	894	Species:	Drosophila melanogaster
Sequence 2:	NP_001260435.1	Gene:	kek4 / 34718	FlyBaseID:	FBgn0032484	Length:	649	Species:	Drosophila melanogaster

Alignment Length:	616	Identity:	151/616 - (24%)
Similarity:	247/616 - (40%)	Gaps:	145/616 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 CVCKWKGGKQTVECGGQQLSNLPEGMDPGTQVLNFSGNALQVLQSERFLRMDLLNLQKIYLSRNQ 89
            |.|||..||:|.:|....||.:||.:.|..|||:.|.|.:..|:...||...|.||||:.:....
  Fly    45 CHCKWNSGKKTADCRNLSLSGVPEYLSPEVQVLDLSHNHIFYLEENAFLTTHLQNLQKLLIRNGT 109

  Fly    90 LIRIHEKAFRGLTNLVELDLSENALQNVPSETFQDYSSLMRLSLSGNPIRELKTSAFRHLSFLTT 154
            |..:::::|..|..|:|||||.|.|.::....|...|.:..:.|:||.::.|:...||:|.:|..
  Fly   110 LKYLNQRSFTQLQILIELDLSNNLLVDLLPNVFDCLSKVRAIFLNGNLLQALRHGVFRNLKYLHK 174

  Fly   155 LELSNCQVERIENEAFVGMDNLEWLRLDGNRIG--FIQGTHILPKSLHGISLHSNRWNCDCRLLD 217
            :||...::..|:.:||||:..|..:.||.|.:.  .::....|.| |..:||..|.|||.|.|..
  Fly   175 IELKRNRLVSIDAKAFVGVPLLSQIYLDNNELTKLRVESFQDLTK-LTALSLVENPWNCTCDLQM 238

  Fly   218 IHFWLVNYN--TPLAEEPKCMEPARLKGQVIKSLQREQLACLPEVSPQSSYTEVSEGR-NMSITC 279
            ...:::..|  ||   ...|..|.:|:|::....|.|..||.|::...:..|.::..: |:::.|
  Fly   239 FRDFVIGMNLYTP---PTSCHYPLQLRGRLWIEDQPEAFACKPKIVYPTLSTSINTSKENVTLIC 300

  Fly   280 LVRAIPEPKVLWLFNGQVMSNDS----LMDNLHMYYYI---DET-IGVSGAEEKRSEIFIYNVGA 336
            .|...|...:.|.:..||..:.|    .:....:|..:   ||: |...|.:...|.:.|.|...
  Fly   301 RVHGSPNTVIAWDYTNQVYESRSKPVKSLQKQRIYIELLREDESKIRKFGHDVFVSRLTIVNARK 365

  Fly   337 EDNGTFSCVGQNIAGTTFSNYTLRVIIKEPPVVNEVSFPRDYMNYIVASSAGG----GIIFVVLL 397
            .|.|.::|:.:|..|.  .:..:.|::::.  :..:|........||...|.|    .|:|.::.
  Fly   366 SDEGVYTCLAENPGGK--DSVHISVVVQKD--MERISLIDSNFFAIVCLIAMGFLSMSILFSLVT 426

  Fly   398 CTIVVKCKK-----------TSEPAKQRKKCDQVTSIAGGTDSSTGSTQDTGM-----GMMKCAS 446
            |.|..:.|:           ||.|.:                 |.||.:.|.:     |:::.:.
  Fly   427 CLIFKRFKQFHPGQHTYLQPTSLPVQ-----------------SPGSEEATAISALSSGVIRESK 474

  Fly   447 ILNDGGDSMNGNPGLLLGDTLTPTKAANGAAGGGIILGNQMKQNLLLYATPNSAQQQLQLNVNLM 511
            |:                  |.|..|.|          ....:|..|:.|.|
  Fly   475 IV------------------LDPLSAIN----------EPSNKNYTLFKTSN------------- 498

  Fly   512 GTGPGSPPLLLSNGHGLAAAYCSPPASLRNYQE-------KNPDLVNDAESV------------- 556
                       |||        |.....|||::       ...:|.|.|||:
  Fly   499 -----------SNG--------SEYMHTRNYKDVRLNSNTYTENLDNQAESISSRNRELYSNIAG 544

  Fly   557 ---KHKLKTAVSLDGAGEYETQSDCGQYEGC 584
               |.:||....||    .:::....|..||
  Fly   545 DREKEELKQKDELD----KDSRQSSLQSTGC 571

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek2	NP_523551.1	leucine-rich repeat	34..52	CDD:275380	6/17 (35%)
		leucine-rich repeat	54..79	CDD:275380	9/24 (38%)
		LRR_8	79..138	CDD:290566	20/58 (34%)
		LRR_RI	<80..187	CDD:238064	35/106 (33%)
		leucine-rich repeat	80..103	CDD:275380	6/22 (27%)
		leucine-rich repeat	104..127	CDD:275380	9/22 (41%)
		LRR_8	126..186	CDD:290566	20/59 (34%)
		leucine-rich repeat	128..151	CDD:275380	7/22 (32%)
		leucine-rich repeat	152..175	CDD:275380	8/22 (36%)
		leucine-rich repeat	176..198	CDD:275380	5/23 (22%)
		TPKR_C2	207..256	CDD:301599	15/50 (30%)
		I-set	258..361	CDD:254352	23/111 (21%)
		Ig_2	263..361	CDD:290606	22/106 (21%)
kek4	NP_001260435.1	leucine-rich repeat	75..99	CDD:275380	9/23 (39%)
		LRR_8	99..158	CDD:290566	20/58 (34%)
		leucine-rich repeat	100..123	CDD:275380	6/22 (27%)
		leucine-rich repeat	124..147	CDD:275380	9/22 (41%)
		LRR_8	146..206	CDD:290566	20/59 (34%)
		leucine-rich repeat	148..171	CDD:275380	7/22 (32%)
		leucine-rich repeat	172..195	CDD:275380	8/22 (36%)
		leucine-rich repeat	196..219	CDD:275380	5/22 (23%)
		TPKR_C2	228..277	CDD:301599	16/51 (31%)
		IG_like	294..390	CDD:214653	22/97 (23%)
		Ig	296..387	CDD:143165	20/92 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005302
OrthoInspector	1	1.000	-	-		mtm8422
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24366
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	4.010