DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek2 and kek1

DIOPT Version :9

Sequence 1:	NP_523551.1	Gene:	kek2 / 34582	FlyBaseID:	FBgn0015400	Length:	894	Species:	Drosophila melanogaster
Sequence 2:	NP_001303320.1	Gene:	kek1 / 34688	FlyBaseID:	FBgn0015399	Length:	880	Species:	Drosophila melanogaster

Alignment Length:	908	Identity:	276/908 - (30%)
Similarity:	388/908 - (42%)	Gaps:	175/908 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 VCVCKWKGGKQTVECGGQQLSNLPEGMDPGTQVLNFSGNALQVLQSERFLRMDLLNLQKIYLSRN 88
            ||.||||||||||||..:.|..:||.:||.||||:.|||.||.|.:|:|:|.:||||||:||...
  Fly    93 VCACKWKGGKQTVECIDRHLIQIPEHIDPNTQVLDMSGNKLQTLSNEQFIRANLLNLQKLYLRNC 157

  Fly    89 QLIRIHEKAFRGLTNLVELDLSENALQNVPSETFQDYSSLMRLSLSGNPIRELKTSAFRHLSFLT 153
            ::..|..:.|:|||||||||||.|.|..|||.......||..|:|:.|.|.::::.||.:...|.
  Fly   158 KIGEIERETFKGLTNLVELDLSHNLLVTVPSLALGHIPSLRELTLASNHIHKIESQAFGNTPSLH 222

  Fly   154 TLELSNCQVERIENEAFVGMDNLEWLRLDGNRIGFIQGTHILPKS------LHGISLHSNRWNCD 212
            .|:||:|.::.|..:||.|:..|..|||:||::     :.:|||:      ||||.||.|.|.||
  Fly   223 KLDLSHCDIQTISAQAFGGLQGLTLLRLNGNKL-----SELLPKTIETLSRLHGIELHDNPWLCD 282

  Fly   213 CRLLDIHFWLVNYNTPLAEEPKCM-EPARLKGQVIKSLQREQLACLPEVSPQSSYTEVSEGRNMS 276
            |||.|...||:..|.|....|.|. .|.|:..:....|..::.||.||:.|.|.|.|.:.|.|.|
  Fly   283 CRLRDTKLWLMKRNIPYPVAPVCSGGPERIIDRSFADLHVDEFACRPEMLPISHYVEAAMGENAS 347

  Fly   277 ITCLVRAIPEPKVLWLFNGQVMSNDSLMDNLHMYYYIDETIGVSGAEEKRSEIFIYNVGAEDNGT 341
            |||..||:|...:.|.:||::::|:|........:.:::   |.|..||||::.:.|....|:..
  Fly   348 ITCRARAVPAANINWYWNGRLLANNSAFTAYQRIHMLEQ---VEGGFEKRSKLVLTNAQETDSSE 409

  Fly   342 FSCVGQNIAGTTFSNYTLRVIIKEPPVVNEVSFPRDYMNYIVASSAG--GGIIFV--VLLCTIVV 402
            |.||.:|.||...:|:||.|.::...:.:..|      ..||..||.  ..|:|.  |::|.::.
  Fly   410 FYCVAENRAGMAEANFTLHVSMRAAGMASLGS------GQIVGLSAALVALIVFALGVIMCLLLR 468

  Fly   403 KCKKTSEPAKQRKKCDQVTSIAGGTDSSTGSTQD-TGMGMMKCASILNDGGDSMNGNPGLLLGDT 466
            ..::....:|.....:.:||: ...:|.|..||. ||.|.:        ||
  Fly   469 VKRQPYVDSKTPNHMEVITSV-NHQNSITNKTQPATGNGSI--------GG-------------- 510

  Fly   467 LTPTKAANGAAG----GGIILGNQM-KQNLLLYATPNSAQQQLQLNVNLMGTGP-GSPPLLL--- 522
               ...||||..    ||::.|..: :::......|:....|...|       | ..||.|.
  Fly   511 ---VVIANGAVANIIDGGVVQGGTLERKSSGRGGVPHGVHDQRSAN-------PVQKPPRLTDLP 565

  Fly   523 -------SNGHGLAAAYC--SPPASLRNYQEKNPDLVNDAE--------SVKHKLKTAVSLDGAG 570
                   :||..|:.|.|  ||..|..| ...||||:||.:        .:|....:.|.:.|:|
  Fly   566 YSTQGYDNNGSVLSTASCFISPSGSTGN-GGNNPDLINDTKRFGSDEFADLKIPPISGVGVGGSG 629

  Fly   571 EYETQSDCGQYEGCYQLAAAPHPHQGHQHPHPGHPLMGRFAQAMTTLPRGMQLKPAPHQVDVHLN 635
            ||...:.|   :..|                                |.|:.         .|..
  Fly   630 EYSRANGC---DSLY--------------------------------PSGLW---------EHGA 650

  Fly   636 PVCFLGQDGSFAYDYSSAHMVQQPPQQQQQQQQVQPANNFYRTLPHNRLHKQQQFQAAAAAGGNV 700
            ||.....|..|...|:....:....|.....::....:.|.:|.|  |.|.||         |.:
  Fly   651 PVGTTSADDLFMKRYTDKTPIIDSTQLYDLHERTAATDYFSKTFP--RSHLQQ---------GMM 704

  Fly   701 GVGGNPTLRYSLEAEFIQRGPTVSY-EKYQLPNVRFTAEGYPQQQQQQQQQLQQQQQLQLQQQ-- 762
            ..||..|...|.....:..|.:..| ..|.||.|       |..:.|...|||.....|||||
  Fly   705 TGGGGGTSTASTVTTNLSGGSSSGYPNDYGLPLV-------PGAEHQHNHQLQMHPLQQLQQQLT 762

  Fly   763 ----HQFPSPPEGYKSDLAVMP-APFQQWPSCLPGYRFAQSPTSLPAVATPPPAAVVATPPPPTS 822
                ||   ..||  |.....| ...:..|....|.....|..|.|..|.....|..|..|
  Fly   763 STLNHQ---KQEG--SSTGSSPHFSSRTLPRLHEGSGGGGSSRSSPTPAVSGGHANQAANP---- 818

  Fly   823 AVSTQSTATSTIPELDESEASSPRLEEAAG-SAAPPAGEEESSDTAKLKQLNGPLADSPDEGY 884
              ||.|::.|.:|......|.:.|:.:..| ...||.       ||..:.|.....:||||||
  Fly   819 --STSSSSCSILPNGQPINAKTIRVWQKGGVPVLPPV-------TALKRALISSSRNSPDEGY 872

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek2	NP_523551.1	leucine-rich repeat	34..52	CDD:275380	8/17 (47%)
		leucine-rich repeat	54..79	CDD:275380	14/24 (58%)
		LRR_8	79..138	CDD:290566	29/58 (50%)
		LRR_RI	<80..187	CDD:238064	46/106 (43%)
		leucine-rich repeat	80..103	CDD:275380	9/22 (41%)
		leucine-rich repeat	104..127	CDD:275380	12/22 (55%)
		LRR_8	126..186	CDD:290566	23/59 (39%)
		leucine-rich repeat	128..151	CDD:275380	7/22 (32%)
		leucine-rich repeat	152..175	CDD:275380	9/22 (41%)
		leucine-rich repeat	176..198	CDD:275380	8/21 (38%)
		TPKR_C2	207..256	CDD:301599	17/49 (35%)
		I-set	258..361	CDD:254352	37/102 (36%)
		Ig_2	263..361	CDD:290606	34/97 (35%)
kek1	NP_001303320.1	leucine-rich repeat	103..122	CDD:275380	9/18 (50%)
		LRR_RI	<119..277	CDD:238064	73/162 (45%)
		leucine-rich repeat	123..148	CDD:275380	14/24 (58%)
		LRR_8	148..207	CDD:290566	29/58 (50%)
		leucine-rich repeat	149..172	CDD:275380	9/22 (41%)
		leucine-rich repeat	173..196	CDD:275380	12/22 (55%)
		LRR_8	195..255	CDD:290566	23/59 (39%)
		leucine-rich repeat	197..220	CDD:275380	7/22 (32%)
		leucine-rich repeat	221..244	CDD:275380	9/22 (41%)
		leucine-rich repeat	245..268	CDD:275380	9/27 (33%)
		LRRCT	277..327	CDD:214507	17/49 (35%)
		IG_like	338..429	CDD:214653	32/93 (34%)
		Ig	346..426	CDD:143165	27/82 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	48	1.000	Domainoid score	I8032
eggNOG	1	0.900	-	-		E33208_3BCQX
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	92	1.000	Inparanoid score	I5090
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D23311at33392
OrthoFinder	1	1.000	-	-		FOG0005302
OrthoInspector	1	1.000	-	-		mtm8422
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24366
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	8	7.970