DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek2 and haf

DIOPT Version :9

Sequence 1:	NP_523551.1	Gene:	kek2 / 34582	FlyBaseID:	FBgn0015400	Length:	894	Species:	Drosophila melanogaster
Sequence 2:	NP_001356954.1	Gene:	haf / 33339	FlyBaseID:	FBgn0261509	Length:	1347	Species:	Drosophila melanogaster

Alignment Length:	1295	Identity:	255/1295 - (19%)
Similarity:	366/1295 - (28%)	Gaps:	594/1295 - (45%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 PLLALLAIT--------AACP-----PEV---CVCKWKGGKQ-TVEC------------------ 38
            |||.||.:.        |.||     |::   |:|.:..|:: :|:|
  Fly    16 PLLLLLPLILGRLHVAHAQCPWQRDVPDLQTSCICAYNLGRELSVQCDQVDFSQLLAAMNTHARL 80

  Fly    39 --------GGQQLSNLPE---------------------------GMDPGTQVLNFSGNALQVLQ 68
                    ....:|.||:                           |.:...:.||...|.|..:.
  Fly    81 KPVDLLYVNNSTISELPDAVFSNLSLHNLQLSSCGIQRIATGAFKGQESVLRNLNLQDNLLADVP 145

  Fly    69 SERFLRMDLLNLQKIYLSRNQLIRIHEKAFRGLTNLVELDLSEN--------------ALQN--- 116
            .|....:..|||  :.||:|||..|.:.||.|||.|..|.|::|              :|:|
  Fly   146 VEALKVLGKLNL--LDLSKNQLSHIPDDAFVGLTKLSTLKLNDNNVTLASNAFRGLEQSLKNLNL 208

  Fly   117 -------VPSETFQDYSSLMRLSLSGNPIRELKTS----AFRHLSFLTTLELSNCQVERIENEAF 170
                   || |:.:...||..|.||.|.|:||..:    .|..|..||.|.|....::.|...||
  Fly   209 KGTKQRKVP-ESIRGLKSLAFLDLSQNGIKELPGAGGIRVFDGLDALTALNLERNLIQSIGETAF 272

  Fly   171 VG----------MDNL---------------------------------------EWLRLDGNRI 186
            .|          ::||                                       ..|.||||.:
  Fly   273 AGVRKTLSSLSLLNNLLAEFPIGAVHSLKELRVLDIGFNLLTSLPEAAFRGNPGITLLALDGNPL 337

  Fly   187 GFI-QGTHI-LPKSLHGISLHSNRWNCDCRLLDIHFWLVNYNTPLAEEPK----CMEPARLKGQV 245
            ..: :|... |..:|.|:||.....:|||:|..:..|:.|.:..:....:    |..|.|.:.:.
  Fly   338 SSVPEGAFAHLNATLRGLSLGGRFLHCDCKLRWVAEWIRNGDLQVTSRERNPQFCGTPPRFRDRG 402

  Fly   246 IKSLQREQLACLPEVSPQSSYTEVSEGRNMSITCLVRAIPEPKVLWLFNGQVMSNDSLMDNLHMY 310
            ..|:|.|:|:| |:::..:....|....|:..|     :|.            |.||      :.
  Fly   403 FYSIQPEELSC-PDIADAALRGPVGLADNLKPT-----LPS------------SPDS------VE 443

  Fly   311 YYIDETIGVSGAEEKRSEIFIYNVGAEDNGTFSCVGQNIAGTTFSNYTLRVIIKEPPVVNEVSFP 375
            |......|..|.....|.....:|   .:.|.:........||.:..|.|.....||..:..:
  Fly   444 YETGTGTGTVGTGTAASAPVTSSV---SSSTSTTTPTTTTTTTTAEPTTRRSTTRPPTKSTTT-- 503

  Fly   376 RDYMNYIVASSAGGGIIFVVLLCTIVVKCKKTSEPAKQRKKCDQVTSIAGGTDSSTGSTQDTGMG 440
                  |.|::|                 ...|.|........|.|||...:.||:.|:..||.|
  Fly   504 ------ISATTA-----------------SPASNPPVNGTGTVQATSITTSSSSSSSSSTSTGHG 545

  Fly   441 MMKCASILNDGGDSMNGNPGLLLGDTLTPTKAANGAAGGGIILGNQMKQNLLLYATPNSAQQQLQ 505
            ..|.|.....|..:.|||.|:             |.|||             |:.
  Fly   546 NGKQAPGWRQGVTNGNGNSGV-------------GGAGG-------------LHK---------- 574

  Fly   506 LNVNLMGTGPGSPPLLLSNGHGLAAAYCSPPASLRNYQEKNPDLVNDAESVKHKLKTAVSLDGAG 570
                     |..|||:|                  .|..:....::||..|  ::|.|...|.:.
  Fly   575 ---------PQRPPLVL------------------GYPPQRGTRIDDANEV--QVKHAFRQDSSV 610

  Fly   571 EYETQSDCGQYEG---CYQLAAAPHPHQGHQHPHPGHPLMGRFAQAMTTLPRGMQLKPAPHQ--- 629
            ..:..||.....|   .|:|.       |.:....|.||        .:..|..::|..|.|
  Fly   611 IIQWDSDTANILGFRVVYRLF-------GEKAFKQGPPL--------ESSEREFKIKNVPAQECI 660

  Fly   630 -------VDVHLNP-------------------------------VC---------FL------- 640
                   .::|:.|                               :|         |:
  Fly   661 IVCVISLEELHVTPETVPYQQCREVRTVASQASNMDKITIAASAAICGTIIVAVIVFIAASRRSR 725

  Fly   641 ---------------------------GQDGSFA----------YDYSSAHM-----------VQ 657
                                       |..||.|          :|..||:.           |:
  Fly   726 KLQSSQQKSPLPIGGLPVNCCGPTGSPGPLGSIATLSAFNNHKEWDQVSAYSGRSIPRPRIYPVE 790

  Fly   658 QPPQQQQQ-----------------QQQVQPANNFYR---------TLPHNRLHKQQQFQAAAAA 696
            ||...:..                 |.|...:||.:|         .|.::|...:|..|:.|||
  Fly   791 QPDDMRSHFSGMPGKVGKSRSLADGQSQHSFSNNSHRGYLGSAFPSNLVNSRPELRQSRQSLAAA 855

  Fly   697 -----------------------GGNVGVGGN--------------------------------- 705
                                   |||.|.|||
  Fly   856 SERMSRASYAGSIHGGNGGGGGLGGNGGGGGNGLPVSSLMAMSGMVGGGGPASIASSARRSRPRS 920

  Fly   706 ---------------PTLRYSLEAE---------------------FIQRGPTVS---------- 724
                           |..|||....                     ::.|.||..
  Fly   921 RSREQLNTTHIHNHRPGSRYSQAGSTHTLNNYCDTSDNWTDHDMDIYMARNPTTRNGLVPLXGRL 985

  Fly   725 ---------------YEKYQLPNVRFT---AEGYPQQQQQQQQQLQQQQ-----QLQLQQQHQF- 765
                           : :|..|.:..|   ..|..|||||||||.||||     |.|.|||||.
  Fly   986 TLSXYFNVVLNWDGIFXQYLTPTIEGTEGRGRGRRQQQQQQQQQQQQQQQHQQLQHQQQQQHQHQ 1050

  Fly   766 ------PSPPEGYKSDLAVMPAPFQQWPSCLPGYRFAQSPTS-----LPAV--ATPPPAAVVATP 817
                  ....:.:::|        |||..   .|:.||....     :|..  .|.||..|
  Fly  1051 LQQLRNERHQQRHRND--------QQWEQ---PYQPAQQQHQRLQYYMPQTERCTSPPDVV---- 1100

  Fly   818 PPPTSAVSTQSTATSTIPELDESEASSPRLEEAAGSAAPPAGEEESSDTAKLKQLNGPLA 877
              |.:|....|..||| ...|.|.:.               |...||.:...:|...|||
  Fly  1101 --PRAANFHNSNTTST-GHNDNSNSH---------------GSSSSSSSNIAQQQQAPLA 1142

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek2	NP_523551.1	leucine-rich repeat	34..52	CDD:275380	6/71 (8%)
		leucine-rich repeat	54..79	CDD:275380	5/24 (21%)
		LRR_8	79..138	CDD:290566	28/82 (34%)
		LRR_RI	<80..187	CDD:238064	47/183 (26%)
		leucine-rich repeat	80..103	CDD:275380	11/22 (50%)
		leucine-rich repeat	104..127	CDD:275380	9/46 (20%)
		LRR_8	126..186	CDD:290566	26/112 (23%)
		leucine-rich repeat	128..151	CDD:275380	10/26 (38%)
		leucine-rich repeat	152..175	CDD:275380	8/32 (25%)
		leucine-rich repeat	176..198	CDD:275380	8/62 (13%)
		TPKR_C2	207..256	CDD:301599	13/52 (25%)
		I-set	258..361	CDD:254352	17/102 (17%)
		Ig_2	263..361	CDD:290606	16/97 (16%)
haf	NP_001356954.1	LRR	<52..>252	CDD:227223	45/202 (22%)
		leucine-rich repeat	86..105	CDD:275380	3/18 (17%)
		leucine-rich repeat	106..129	CDD:275380	1/22 (5%)
		LRR_8	131..189	CDD:338972	23/59 (39%)
		leucine-rich repeat	131..154	CDD:275380	5/22 (23%)
		leucine-rich repeat	155..178	CDD:275380	13/24 (54%)
		leucine-rich repeat	179..202	CDD:275380	4/22 (18%)
		leucine-rich repeat	203..225	CDD:275380	5/22 (23%)
		leucine-rich repeat	226..253	CDD:275380	10/26 (38%)
		LRR_8	254..337	CDD:338972	15/82 (18%)
		leucine-rich repeat	254..302	CDD:275380	10/47 (21%)
		leucine-rich repeat	303..326	CDD:275380	0/22 (0%)
		leucine-rich repeat	327..350	CDD:275380	7/22 (32%)
		PCC	332..>413	CDD:188093	23/80 (29%)
		PRK10927	<1061..>1097	CDD:236797	9/46 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24366
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100