DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kek2 and Lingo4

DIOPT Version :9

Sequence 1:	NP_523551.1	Gene:	kek2 / 34582	FlyBaseID:	FBgn0015400	Length:	894	Species:	Drosophila melanogaster
Sequence 2:	NP_796224.1	Gene:	Lingo4 / 320747	MGIID:	2444651	Length:	618	Species:	Mus musculus

Alignment Length:	527	Identity:	117/527 - (22%)
Similarity:	170/527 - (32%)	Gaps:	194/527 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LPIWIPLLALLAI----TAACPPEVCVCKWKGGKQTVECGGQQLSNLPEGMDPGTQVLNFSGNAL 64
            || |.|||.||.:    .::||   .||......:.|.|..::|..:|.|:...|::|:.|||.|
Mouse    37 LP-WSPLLFLLLLPGGSISSCP---TVCDCTSQTRAVFCAHRRLDTIPGGLPLDTELLDLSGNRL 97

  Fly    65 QVLQSERFLRMDLLNLQKIYLSRNQLIRIHEKAFRGLTNLVELDLSENALQNVP----------- 118
            ..||.....|:.  .||::.||.|||..:...||.||.:|:.|.|..|.|:.|.
Mouse    98 WGLQRGMLSRLG--QLQELDLSYNQLSTLEPGAFHGLQSLLTLRLQGNRLRIVGPGIFSGLTALT 160

  Fly   119 -------------SETFQDYSSLMRLSLSGNPIRELKTSAFRHLSFLTTLELSNC---------- 160
                         ...|.:..||.:|.:..|.:..:...||..|:.|:|:.|..|
Mouse   161 LLDLRLNQIVLFLDGAFSELGSLQQLEVGDNHLVFVAPGAFAGLAKLSTITLERCNLSTVPGLAL 225

  Fly   161 --------------QVERIENEAFVGMDNLE------WLRLD----GNRIGF------------- 188
                          .:||:...|..|:..|:      |..|:    |:.:|.
Mouse   226 AQLPALVALRLRELDIERLPAGALRGLGQLKELEIHHWPSLEALDPGSLVGLNLSSLAITRCNLS 290

  Fly   189 -----------------------------------------IQG---THILPKSLHGIS------ 203
                                                     :.|   |.|...:.||::
Mouse   291 SVPFQALHHLSFLRILDLSQNPISAIPARRLSPLVRLQELRLSGACLTSIAAHAFHGLTAFHLLD 355

  Fly   204 ------------------------LHSNRWNCDCRLLDIHFWLVNYNTPL---AEEPKCMEPARL 241
                                    |..|...||||||    ||:.....|   ...|.|..|..:
Mouse   356 VADNALQTLEETAFPSPDKLVTLRLSGNPLTCDCRLL----WLLRLRRRLDFGTSPPACAGPQHV 416

  Fly   242 KGQVIKS----LQREQLACLPEVSPQSS--YTEVSEGRNMSITCLVRAIPEPKVLWL-----FNG 295
            :|:.::.    |......|.|.:..:|.  :....||.:...:|.....|.|.|.|:     :.|
Mouse   417 QGKSLREFSDILPPGHFTCKPALIRKSGPRWVIAEEGGHAVFSCSGDGDPAPTVSWMRPQGAWLG 481

  Fly   296 QVMSNDSLMDNLHMYYYIDETIGVSGAEEKRSEIFIYNVGAEDNGTFSCVGQNIAGTTFSNYTLR 360
            :|.....|.|               |..|.||      |...|.|.:.||..|:||.......|.
Mouse   482 RVGRVRVLED---------------GTLEIRS------VQLRDRGAYVCVVSNVAGNDSLRTWLE 525

  Fly   361 VIIKEPP 367
            ||..|||
Mouse   526 VIQVEPP 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek2	NP_523551.1	leucine-rich repeat	34..52	CDD:275380	5/17 (29%)
		leucine-rich repeat	54..79	CDD:275380	9/24 (38%)
		LRR_8	79..138	CDD:290566	22/82 (27%)
		LRR_RI	<80..187	CDD:238064	37/164 (23%)
		leucine-rich repeat	80..103	CDD:275380	11/22 (50%)
		leucine-rich repeat	104..127	CDD:275380	7/46 (15%)
		LRR_8	126..186	CDD:290566	19/93 (20%)
		leucine-rich repeat	128..151	CDD:275380	6/22 (27%)
		leucine-rich repeat	152..175	CDD:275380	8/46 (17%)
		leucine-rich repeat	176..198	CDD:275380	8/88 (9%)
		TPKR_C2	207..256	CDD:301599	15/55 (27%)
		I-set	258..361	CDD:254352	26/109 (24%)
		Ig_2	263..361	CDD:290606	25/104 (24%)
Lingo4	NP_796224.1	LRRNT	56..89	CDD:214470	10/35 (29%)
		leucine-rich repeat	69..86	CDD:275380	5/16 (31%)
		leucine-rich repeat	87..110	CDD:275380	9/24 (38%)
		LRR_8	90..145	CDD:290566	23/56 (41%)
		leucine-rich repeat	111..134	CDD:275380	11/22 (50%)
		LRR_RI	112..345	CDD:238064	40/232 (17%)
		LRR_8	134..193	CDD:290566	11/58 (19%)
		leucine-rich repeat	135..158	CDD:275380	6/22 (27%)
		leucine-rich repeat	159..182	CDD:275380	1/22 (5%)
		LRR_8	182..237	CDD:290566	11/54 (20%)
		leucine-rich repeat	183..206	CDD:275380	6/22 (27%)
		leucine-rich repeat	207..230	CDD:275380	4/22 (18%)
		leucine-rich repeat	231..254	CDD:275380	4/22 (18%)
		leucine-rich repeat	255..302	CDD:275380	5/46 (11%)
		LRR_8	278..334	CDD:290566	0/55 (0%)
		leucine-rich repeat	303..326	CDD:275380	0/22 (0%)
		LRR_8	326..385	CDD:290566	7/58 (12%)
		leucine-rich repeat	327..350	CDD:275380	5/22 (23%)
		leucine-rich repeat	351..369	CDD:275380	0/17 (0%)
		leucine-rich repeat	375..387	CDD:275378	2/11 (18%)
		IG_like	445..526	CDD:214653	24/101 (24%)
		Ig	456..526	CDD:299845	22/90 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8825
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910