DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek2 and Lingo1

DIOPT Version :9

Sequence 1:	NP_523551.1	Gene:	kek2 / 34582	FlyBaseID:	FBgn0015400	Length:	894	Species:	Drosophila melanogaster
Sequence 2:	NP_001094192.1	Gene:	Lingo1 / 315691	RGDID:	1308668	Length:	620	Species:	Rattus norvegicus

Alignment Length:	588	Identity:	123/588 - (20%)
Similarity:	195/588 - (33%)	Gaps:	217/588 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LPIWIPLLALL------AITAACPPEVCVCKWKGGKQTVECGGQQLSNLPEGMDPGTQVLNFSGN 62
            |..|.|:|.|:      .....|||.   |:.....:.|.|..::...:|||:...|::|:...|
  Rat    20 LACWQPILLLVLGSVLSGSATGCPPR---CECSAQDRAVLCHRKRFVAVPEGIPTETRLLDLGKN 81

  Fly    63 ALQVLQSERFLRM----------------------DLLNLQKIYLSRNQLIRIHEKAFRGLTNLV 105
            .::.|..:.|...                      :|.||:.:.|..|:|..|....|.||:||.
  Rat    82 RIKTLNQDEFASFPHLEELELNENIVSAVEPGAFNNLFNLRTLGLRSNRLKLIPLGVFTGLSNLT 146

  Fly   106 ELDLSENALQNVPSETFQDYSSLMRLSLSGNP--------------------------------- 137
            :||:|||.:..:....|||..:|..|.:..|.
  Rat   147 KLDISENKIVILLDYMFQDLYNLKSLEVGDNDLVYISHRAFSGLNSLEQLTLEKCNLTSIPTEAL 211

  Fly   138 ----------IRELKTSAFRHLSF-----------------------------LTTLELSNCQVE 163
                      :|.|..:|.|..||                             ||:|.:::|.:.
  Rat   212 SHLHGLIVLRLRHLNINAIRDYSFKRLYRLKVLEISHWPYLDTMTPNCLYGLNLTSLSITHCNLT 276

  Fly   164 RIENEAFVGMDNLEWLRLDGNRIGFIQGT--HIL-----------------PKSLHGIS------ 203
            .:...|...:..|.:|.|..|.||.|:|:  |.|                 |.:..|::
  Rat   277 AVPYLAVRHLVYLRFLNLSYNPIGTIEGSMLHELLRLQEIQLVGGQLAVVEPYAFRGLNYLRVLN 341

  Fly   204 ------------------------LHSNRWNCDCRLLDI--HFWLVNYNTPLAEEPKCMEPARLK 242
                                    |.||...||||||.:  ..|.:|:|   .::|.|..|..::
  Rat   342 VSGNQLTTLEESAFHSVGNLETLILDSNPLACDCRLLWVFRRRWRLNFN---RQQPTCATPEFVQ 403

  Fly   243 GQVIKSLQREQLACLPEVSPQSSYT--------------EVSEGRNMSITCLVRAIPEPKVLWLF 293
            |:..|.        .|:|...:.:|              .|.||..:...|.....|.|.:|||.
  Rat   404 GKEFKD--------FPDVLLPNYFTCRRAHIRDRKAQQVFVDEGHTVQFVCRADGDPPPAILWLS 460

  Fly   294 NGQVMSNDSLMDNLHMYYYIDETIGVSGAEEKRSEIFIYNVGAEDNGTFSCVGQNIAGT------ 352
            ..:.:.  |...|..:..:.|.|:.|..|:            .:||||:.|:..|..|.
  Rat   461 PRKHLV--SAKSNGRLTVFPDGTLEVRYAQ------------VQDNGTYLCIAANAGGNDSMPAH 511

  Fly   353 ----TFS-------NYTLRVIIKEP------PVVNEVSFPRDYMNYIVASSAGG-GIIFVVLLCT 399
                ::|       |.|...|..:|      .....|.||.|....|:|::.|. ..:.|||.|.
  Rat   512 LHVRSYSPDWPHQPNKTFAFISNQPGEGEANSTRATVPFPFDIKTLIIATTMGFISFLGVVLFCL 576

  Fly   400 IVV 402
            :::
  Rat   577 VLL 579

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek2	NP_523551.1	leucine-rich repeat	34..52	CDD:275380	5/17 (29%)
		leucine-rich repeat	54..79	CDD:275380	6/46 (13%)
		LRR_8	79..138	CDD:290566	22/101 (22%)
		LRR_RI	<80..187	CDD:238064	36/178 (20%)
		leucine-rich repeat	80..103	CDD:275380	8/22 (36%)
		leucine-rich repeat	104..127	CDD:275380	9/22 (41%)
		LRR_8	126..186	CDD:290566	18/131 (14%)
		leucine-rich repeat	128..151	CDD:275380	7/65 (11%)
		leucine-rich repeat	152..175	CDD:275380	5/22 (23%)
		leucine-rich repeat	176..198	CDD:275380	11/40 (28%)
		TPKR_C2	207..256	CDD:301599	15/50 (30%)
		I-set	258..361	CDD:254352	28/133 (21%)
		Ig_2	263..361	CDD:290606	26/128 (20%)
Lingo1	NP_001094192.1	LRRNT	41..75	CDD:214470	10/36 (28%)
		LRR	<66..371	CDD:227223	57/304 (19%)
		leucine-rich repeat	73..96	CDD:275380	5/22 (23%)
		leucine-rich repeat	97..120	CDD:275380	1/22 (5%)
		LRR_8	120..179	CDD:404697	22/58 (38%)
		leucine-rich repeat	121..144	CDD:275380	8/22 (36%)
		leucine-rich repeat	145..192	CDD:275380	12/46 (26%)
		leucine-rich repeat	193..216	CDD:275380	0/22 (0%)
		leucine-rich repeat	217..264	CDD:275380	6/46 (13%)
		leucine-rich repeat	265..288	CDD:275380	5/22 (23%)
		leucine-rich repeat	289..312	CDD:275380	10/22 (45%)
		leucine-rich repeat	313..336	CDD:275380	2/22 (9%)
		leucine-rich repeat	337..357	CDD:275380	0/19 (0%)
		PCC	341..>421	CDD:188093	19/90 (21%)
		IgI_Lingo-1	423..514	CDD:409561	22/104 (21%)
		Ig strand B	442..446	CDD:409561	0/3 (0%)
		Ig strand C	455..459	CDD:409561	1/3 (33%)
		Ig strand E	480..484	CDD:409561	1/3 (33%)
		Ig strand F	494..499	CDD:409561	2/4 (50%)
		Ig strand G	507..510	CDD:409561	0/2 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46071
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000