DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek2 and Slitrk3

DIOPT Version :9

Sequence 1:	NP_523551.1	Gene:	kek2 / 34582	FlyBaseID:	FBgn0015400	Length:	894	Species:	Drosophila melanogaster
Sequence 2:	NP_001101153.1	Gene:	Slitrk3 / 310519	RGDID:	1310506	Length:	979	Species:	Rattus norvegicus

Alignment Length:	1087	Identity:	205/1087 - (18%)
Similarity:	330/1087 - (30%)	Gaps:	339/1087 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 GLPIWIPLLALLAITAACP------------P--EVCVCKWKGGKQTVECGGQQLSNLPEGMDPG 53
            |..:||.||:.:|:....|            |  :.|.|:.|.....:.|..:..:|:
  Rat    12 GRMLWIILLSTIALGWTTPIPLIEDSEEIDEPCFDPCYCEVKESLFHIHCDSKGFTNI------- 69

  Fly    54 TQVLNF---------SGNALQVLQSERFLRMDLLNLQKIYLSRNQLIRIHEKAFRGLTNLVELDL 109
            :|:..|         ..|:::.|.:..||.::  |...|.|..|.|..|...||.||..|..|.|
  Rat    70 SQITEFWSRPFKLYLQRNSMRKLYTNSFLHLN--NAVSINLGNNALQDIQTGAFNGLKILKRLYL 132

  Fly   110 SENALQNVPSETFQDYSSLMRLSLSGNPIRELKTSAFRHLSFLTTLELSNCQVERIENEAFVGMD 174
            .||.|....::||....||..|....|.|:.:::.|||:||.|..|.|::..:..:....|..:
  Rat   133 HENKLDVFRNDTFLGLESLEYLQADYNVIKRIESGAFRNLSKLRVLILNDNLIPVLPTNLFKAV- 196

  Fly   175 NLEWLRLDGNRIG--FIQG--THILPKSLHGISLHSNRWNCDCRLLDIHFWL--VNYNTPLAEEP 233
            :|..|.|.|||:.  |.:|  .|| .:||..:.|..|.|||.|.::.:..||  :.| |.|..:.
  Rat   197 SLTHLDLRGNRLKVLFYRGMLDHI-GRSLMELQLEENPWNCTCEIVQLKSWLERIPY-TALVGDI 259

  Fly   234 KCMEPARLKGQVIKSLQREQLACL---PEVSPQSSYTEVSEGRNMSITCLVRAIPEPKVLWLFNG 295
            .|..|....|:.::.:::.:|..|   .||........:|..:.                   |.
  Rat   260 TCETPFHFHGKDLREIKKTELCPLLSDSEVEASLGIPHLSSSKE-------------------NA 305

  Fly   296 QVMSNDSLMDNLHMYYYIDETIGVSGAEEKRSEIFIYNVGAEDNGTFSCVGQNIAGTTFSNYTLR 360
            ......|::.::|        ...|..|.|.|                        ......|.:
  Rat   306 WPTKPSSMLSSVH--------FTASSVEYKSS------------------------NKQPKPTKQ 338

  Fly   361 VIIKEPPVVNEVSFPRDYMNYIVASSAGGGI-IFVVLLCT---------IVVKCKKTS------- 408
            .....||..::..:|......|........| |.....||         :.|.||:..
  Rat   339 PRTPRPPSTSQALYPGPNQPPIAPYQTRPPIPIICPTGCTCNLHINDLGLTVNCKERGFNNISEL 403

  Fly   409 --EPAKQRK---KCDQVTSIAGGTDSSTGSTQDTGMGMMKCASILNDGGD---------SMNGN- 458
              .|...:|   ..:.:..|......:..|.....:|..: .|.:.||..         .:|||
  Rat   404 LPRPLNAKKLYLSSNLIQKIYRSDFWNFSSLDLLHLGNNR-ISYVQDGAFINLPNLKSLFLNGND 467

  Fly   459 -----PG----------------------------------LLLGDTLTPTKAANGAAGGGIILG 484
                 ||                                  |.|.:.|..|...:..||..:...
  Rat   468 IEKLTPGMFRGLQSLHYLYFEFNVIREIQPAAFSLMPNLKLLFLNNNLLRTLPTDAFAGTSLARL 532

  Fly   485 NQMKQNLLLYATPNSAQQQL----QLNVNLMGTGPGSPPLLLSNGHGLAAAYCSPPASLRNYQEK 545
            | :::|..||.......:.|    |:::|                                   :
  Rat   533 N-LRKNYFLYLPVAGVLEHLNAIVQIDLN-----------------------------------E 561

  Fly   546 NP-DLVNDAESVKHKLKTAVSLDGAGE----------------YETQSDCGQYEGCYQLAAAPHP 593
            || |...|....|..::|..|:...|:                .|.:..|.:.....|...:| |
  Rat   562 NPWDCTCDLVPFKQWIETISSVSVVGDVLCRTPENLTHRDVRTIELEVLCPEMLHIAQPGPSP-P 625

  Fly   594 HQGHQHPHPGHPLMGRFAQAMTTLPRGMQLKPAPHQVDVHLNPVCFLG----QDGSFAYDYSSAH 654
            ..|..||: |.|..   |......|.|   .|.|..|.:....|.|..    ..|.|||......
  Rat   626 QSGDYHPN-GGPTS---ASPYDFSPPG---GPVPLSVLILSLLVLFFSAVFVAAGLFAYVLRRRR 683

  Fly   655 MVQQPPQQQQQQQQVQPANNFYRTLPHNRLHKQQQFQAAAAAGGNVGVGGNPTLRYSLEAEFIQR 719
              ::.|.:.::|:.|.        |...::...:.|:.:..:||..|.||.|||...      ::
  Rat   684 --KKLPFRSKRQEGVD--------LTGIQMQCHRLFEDSGGSGGGSGSGGRPTLSSP------EK 732

  Fly   720 GPTVSYEKYQLPNVRFTAEGYPQQQQQQQQQLQQQQQLQ-------------------LQQQHQF 765
            .|.|.:....:|:........|..:.::::::.......                   |....||
  Rat   733 APPVGHVYEYIPHPVTQMCNNPIYKPREEEEVAASAAQDTGATDRGGPGTQPPGMGEVLLGSEQF 797

  Fly   766 PSPPEGYKSDLAVMPAPFQQWPSCLPGYRFAQSPTSLPAVAT-----PPP--------------- 810
            ...|:...|:...:....::|       ..|.|.:.|..:.|     |.|
  Rat   798 AETPKENHSNYRTLLEKEKEW-------ALAVSNSQLNTIVTVNHHHPHPHHSAVGGVSGVGGGT 855

  Fly   811 -------------AAVVATPP-----------------PPTSAVSTQSTATSTIPELDESEASSP 845
                         ..||..||                 |....|........|:|:|.|.....|
  Rat   856 GGDLAGFRHHEKNGGVVLFPPGGGCGGGSLLLERERPQPAPCTVGFVDCLYGTVPKLKELHVHPP 920

  Fly   846 -----------RLEEAAGSAAPPAGEEESSDTAKLKQLNGPLADSPD 881
                       ||:|....:|.....:..:..:....|...|...||
  Rat   921 GMQYPDLQQDARLKETLLFSAGKGFTDHQTPKSDYLDLRAKLQTKPD 967

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek2	NP_523551.1	leucine-rich repeat	34..52	CDD:275380	2/17 (12%)
		leucine-rich repeat	54..79	CDD:275380	6/33 (18%)
		LRR_8	79..138	CDD:290566	22/58 (38%)
		LRR_RI	<80..187	CDD:238064	37/106 (35%)
		leucine-rich repeat	80..103	CDD:275380	9/22 (41%)
		leucine-rich repeat	104..127	CDD:275380	8/22 (36%)
		LRR_8	126..186	CDD:290566	19/59 (32%)
		leucine-rich repeat	128..151	CDD:275380	8/22 (36%)
		leucine-rich repeat	152..175	CDD:275380	4/22 (18%)
		leucine-rich repeat	176..198	CDD:275380	10/25 (40%)
		TPKR_C2	207..256	CDD:301599	14/50 (28%)
		I-set	258..361	CDD:254352	11/102 (11%)
		Ig_2	263..361	CDD:290606	9/97 (9%)
Slitrk3	NP_001101153.1	leucine-rich repeat	81..102	CDD:275380	4/22 (18%)
		leucine-rich repeat	103..126	CDD:275380	9/22 (41%)
		LRR_8	105..161	CDD:290566	21/55 (38%)
		leucine-rich repeat	127..150	CDD:275380	8/22 (36%)
		LRR_8	150..208	CDD:290566	19/58 (33%)
		leucine-rich repeat	151..174	CDD:275380	8/22 (36%)
		leucine-rich repeat	175..197	CDD:275380	4/22 (18%)
		leucine-rich repeat	198..402	CDD:275380	50/256 (20%)
		LRRCT	232..>270	CDD:214507	12/38 (32%)
		leucine-rich repeat	403..433	CDD:275380	3/29 (10%)
		LRR_8	432..492	CDD:290566	10/60 (17%)
		LRR_4	433..473	CDD:289563	8/40 (20%)
		leucine-rich repeat	434..457	CDD:275380	4/23 (17%)
		LRR_4	456..497	CDD:289563	5/40 (13%)
		leucine-rich repeat	458..481	CDD:275380	5/22 (23%)
		leucine-rich repeat	482..501	CDD:275380	0/18 (0%)
		leucine-rich repeat	506..528	CDD:275380	6/21 (29%)
		leucine-rich repeat	529..553	CDD:275380	5/24 (21%)
		LRRCT	562..>597	CDD:214507	8/34 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000