DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek2 and Nepn

DIOPT Version :9

Sequence 1:	NP_523551.1	Gene:	kek2 / 34582	FlyBaseID:	FBgn0015400	Length:	894	Species:	Drosophila melanogaster
Sequence 2:	XP_006256553.1	Gene:	Nepn / 309775	RGDID:	1307755	Length:	512	Species:	Rattus norvegicus

Alignment Length:	210	Identity:	56/210 - (26%)
Similarity:	89/210 - (42%)	Gaps:	29/210 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 TVECGGQQLSNLPEGMDPGTQVLNFSGNALQVLQSERFLRMDLLNLQKIYLSRNQLIRIHEKAFR 99
            |:|....:|..||..:....|.|:.|.|.:|.:.:..|  .||.:|:.::|..|.:......|.:
  Rat   281 TLEASQNRLQMLPPRLPSRLQKLDCSSNFIQRVTAPEF--QDLRDLKHLFLDNNVVSLFEAGALQ 343

  Fly   100 GLTNLVELDLSENALQNVPSETFQDYSSLMRLSLSGNPIRELKTSAFRHLSFLTTLELSNCQVER 164
            ..:.|..|.|.:|.|.::|   .:...:|.||.|.||.|:::.....|.|..|..|.|.|.::..
  Rat   344 KCSQLSNLALEQNLLLSIP---LRLPKTLARLDLKGNAIQDMAERELRDLKQLQVLNLRNNKISA 405

  Fly   165 IENEAFVGMDNLEWLRLDGNRIGFIQGTHILPKSLHGISLHSNRWNCDCRLLDIHFWLVNYNTPL 229
            ::.:|..|:..|..|.|||                       |.|||.|.||.....|....|.:
  Rat   406 LDLKALEGLPRLRHLYLDG-----------------------NPWNCTCSLLRAREVLKAKGTDV 447

  Fly   230 AEEPKCMEPARLKGQ 244
             :..:|..||..:|:
  Rat   448 -KGGQCAAPAERQGE 461

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek2	NP_523551.1	leucine-rich repeat	34..52	CDD:275380	5/16 (31%)
		leucine-rich repeat	54..79	CDD:275380	8/24 (33%)
		LRR_8	79..138	CDD:290566	16/58 (28%)
		LRR_RI	<80..187	CDD:238064	30/106 (28%)
		leucine-rich repeat	80..103	CDD:275380	4/22 (18%)
		leucine-rich repeat	104..127	CDD:275380	6/22 (27%)
		LRR_8	126..186	CDD:290566	20/59 (34%)
		leucine-rich repeat	128..151	CDD:275380	9/22 (41%)
		leucine-rich repeat	152..175	CDD:275380	6/22 (27%)
		leucine-rich repeat	176..198	CDD:275380	5/21 (24%)
		TPKR_C2	207..256	CDD:301599	13/38 (34%)
		I-set	258..361	CDD:254352
		Ig_2	263..361	CDD:290606
Nepn	XP_006256553.1	leucine-rich repeat	50..72	CDD:275380
		leucine-rich repeat	73..96	CDD:275380
		leucine-rich repeat	118..141	CDD:275380
		leucine-rich repeat	142..165	CDD:275380
		leucine-rich repeat	166..187	CDD:275380
		leucine-rich repeat	188..211	CDD:275380
		leucine-rich repeat	212..235	CDD:275380
		leucine-rich repeat	236..256	CDD:275380
		LRR_RI	<251..425	CDD:238064	43/171 (25%)
		leucine-rich repeat	257..278	CDD:275380
		leucine-rich repeat	279..299	CDD:275380	5/17 (29%)
		LRR_8	298..358	CDD:290566	16/61 (26%)
		leucine-rich repeat	300..323	CDD:275380	8/24 (33%)
		leucine-rich repeat	324..347	CDD:275380	4/22 (18%)
		leucine-rich repeat	348..371	CDD:275380	7/25 (28%)
		LRR_8	367..426	CDD:290566	20/81 (25%)
		leucine-rich repeat	372..392	CDD:275380	7/19 (37%)
		leucine-rich repeat	393..416	CDD:275380	6/22 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000