DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kek2 and Slitrk4

DIOPT Version :9

Sequence 1:	NP_523551.1	Gene:	kek2 / 34582	FlyBaseID:	FBgn0015400	Length:	894	Species:	Drosophila melanogaster
Sequence 2:	NP_001352040.1	Gene:	Slitrk4 / 245446	MGIID:	2442509	Length:	837	Species:	Mus musculus

Alignment Length:	334	Identity:	87/334 - (26%)
Similarity:	149/334 - (44%)	Gaps:	46/334 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 IWIPLL--ALLAITAA---CPPEVC-VCKWKGGKQTVECGGQQLS-NLPEGMDP---GTQVLNFS 60
            :|:.|:  ||::.|.|   ...|:| ||.....:..:....:::| ..|..:.|   ....|||.
Mouse     3 LWLFLIVSALISSTNADSDISVEICNVCSCVSVENVLYVNCEKVSVYRPNQLKPPWSNFYHLNFQ 67

  Fly    61 GNALQVLQSERFLRMDLLNLQKIYLSRNQLIRIHEKAFRGLTNLVELDLSENALQNVPSETFQDY 125
            .|.|.:|....|:...  :...::|..|:|..|...||.||:.|.:|.|:.|.|:.:.::||...
Mouse    68 NNFLNILYPNTFVNFS--HAVSLHLGNNKLQNIEGGAFLGLSALKQLHLNNNELKILRADTFLGI 130

  Fly   126 SSLMRLSLSGNPIRELKTSAFRHLSFLTTLELSNCQVERIENEAFVGMDNLEWLRLDGNR----- 185
            .:|..|....|.|:.::..||..|..|..|.|::..:..:.:..| ...:|..|.:.|||
Mouse   131 ENLEYLQADYNLIKYIERGAFNKLHKLKVLILNDNLISFLPDNIF-RFASLTHLDIRGNRIQKLP 194

  Fly   186 -IGFIQGTHILPKSLHGISLHSNRWNCDCRLLDIHFWLVN--YNTPLAEEPKCMEPARLKGQVIK 247
             ||.::  ||  ..:..:.|..|.|||.|.||.:..||.|  ||..:. |..|..|:.|.|:::|
Mouse   195 YIGVLE--HI--GRVVELQLEDNPWNCSCDLLPLKAWLENMPYNIYIG-EAICETPSDLYGRLLK 254

  Fly   248 SLQREQLA-----------CLPEVSPQSSYTEVSEGRNMSITCLVRAIPEP-------KVLWLFN 294
            ...:::|.           .||....::.:|  :...:.:.|.|.|.:.:|       |:..:..
Mouse   255 ETNKQELCPMGTGSDFDVRILPPSQQENGFT--TPNGHTTQTTLHRLVTKPPKTTNPSKISGIVA 317

  Fly   295 GQVMSNDSL 303
            |:.:||.:|
Mouse   318 GKALSNRNL 326

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek2	NP_523551.1	leucine-rich repeat	34..52	CDD:275380	2/18 (11%)
		leucine-rich repeat	54..79	CDD:275380	7/24 (29%)
		LRR_8	79..138	CDD:290566	18/58 (31%)
		LRR_RI	<80..187	CDD:238064	31/112 (28%)
		leucine-rich repeat	80..103	CDD:275380	8/22 (36%)
		leucine-rich repeat	104..127	CDD:275380	7/22 (32%)
		LRR_8	126..186	CDD:290566	16/65 (25%)
		leucine-rich repeat	128..151	CDD:275380	7/22 (32%)
		leucine-rich repeat	152..175	CDD:275380	4/22 (18%)
		leucine-rich repeat	176..198	CDD:275380	9/27 (33%)
		TPKR_C2	207..256	CDD:301599	19/61 (31%)
		I-set	258..361	CDD:254352	11/53 (21%)
		Ig_2	263..361	CDD:290606	10/48 (21%)
Slitrk4	NP_001352040.1	internalin_A	<15..>253	CDD:380193	69/245 (28%)
		LRR 1	60..81		7/20 (35%)
		leucine-rich repeat	63..84	CDD:275380	7/22 (32%)
		LRR_8	83..143	CDD:404697	18/61 (30%)
		LRR 2	84..105		6/20 (30%)
		leucine-rich repeat	85..108	CDD:275380	8/22 (36%)
		LRR 3	108..129		7/20 (35%)
		leucine-rich repeat	109..132	CDD:275380	7/22 (32%)
		LRR 4	132..153		6/20 (30%)
		leucine-rich repeat	133..156	CDD:275380	7/22 (32%)
		LRR 5	156..177		4/21 (19%)
		leucine-rich repeat	157..182	CDD:275380	5/25 (20%)
		LRR 6	179..200		7/20 (35%)
		leucine-rich repeat	183..325	CDD:275380	39/148 (26%)
		leucine-rich repeat	326..402	CDD:275380	1/1 (100%)
		leucine-rich repeat	358..378	CDD:275380
		PPP1R42	359..>550	CDD:411060
		LRR 7	378..399
		LRR_8	402..461	CDD:404697
		LRR 8	402..423
		leucine-rich repeat	403..426	CDD:275380
		LRR 9	426..447
		leucine-rich repeat	427..450	CDD:275380
		LRR 10	450..471
		leucine-rich repeat	451..472	CDD:275380
		LRR 11	474..495
		leucine-rich repeat	475..496	CDD:275380
		LRR 12	497..518
		leucine-rich repeat	498..522	CDD:275380
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	113	1.000	Inparanoid score	I4837
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050