DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kek2 and Lingo2

DIOPT Version :9

Sequence 1:	NP_523551.1	Gene:	kek2 / 34582	FlyBaseID:	FBgn0015400	Length:	894	Species:	Drosophila melanogaster
Sequence 2:	NP_001159471.1	Gene:	Lingo2 / 242384	MGIID:	2442298	Length:	606	Species:	Mus musculus

Alignment Length:	596	Identity:	123/596 - (20%)
Similarity:	204/596 - (34%)	Gaps:	231/596 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SGLPIWIPLLALLAI------TAACPPEVCVCKWKGGKQTVECGGQQLSNLPEGMDPGTQVLNFS 60
            :.:|.|.|.|.|..:      |..||..   |:.....::|.|..::|..:|||:...|::|:.|
Mouse     4 TAIPCWQPFLGLAVVLLLMGSTIGCPAR---CECSAQNKSVSCHRRRLLAIPEGIPIETKILDLS 65

  Fly    61 GNALQVLQSERFLRMDLL----------------------NLQKIYLSRNQLIRIHEKAFRGLTN 103
            .|.|:.:..|.|:...||                      ||:.:.|..|:|..:....|.||:|
Mouse    66 KNRLKSINPEEFISYPLLEEIDLSDNIIANVEPGAFNNLFNLRSLRLKGNRLKLVPLGVFTGLSN 130

  Fly   104 LVELDLSENA------------------------------------------------LQNVPSE 120
            |.:||:|||.                                                |..||:|
Mouse   131 LTKLDISENKIVILLDYMFQDLHNLKSLEVGDNDLVYISHRAFSGLLSLEQLTLEKCNLTAVPTE 195

  Fly   121 TFQDYSSLM-----RLSLSGNPIRELK-----------------------------TS------- 144
            ......||:     .|:::..|:...|                             ||
Mouse   196 ALSHLRSLIALHLKHLNINNMPVYAFKRLFHLKNLEIDYWPLLDLMPANSLYGLNLTSLSITNTN 260

  Fly   145 -------AFRHLSFLTTLELSNCQVERIENEAFVGMDNLEWLRLDGNRIGFI-----QGTHIL-- 195
                   ||:||.:||.|.||...:..||...|..:..|:.|.:.|.::..|     ||...|
Mouse   261 LSTVPFLAFKHLVYLTHLNLSYNPISTIEAGMFSDLIRLQELHIVGAQLRTIEPHSFQGLRFLRV 325

  Fly   196 ------------------PKSLHGISLHSNRWNCDCRLLDIHFWLVNYNTPL---AEEPKCMEPA 239
                              |::|..:|:::|...||||||    ||:.....|   .::|.|..|.
Mouse   326 LNVSQNLLETLEENVFSSPRALEVLSINNNPLACDCRLL----WLLQRQPNLQFGGQQPMCAGPD 386

  Fly   240 RLKGQVIKSLQREQLA----C-LPEVSPQS-SYTEVSEGRNMSITCLVRAIPEPKVLWL------ 292
            .::.:..|......|:    | .|::..:. .:..|.||:.:.:.|.....|:|.:.|:
Mouse   387 TIRERSFKDFHSTALSFYFTCKKPKIREKKLQHLLVDEGQTVQLECNADGDPQPVISWVTPRRRF 451

  Fly   293 ----FNGQ--VMSNDSLMDNLHMYYYIDETIGVSGAEEKRSEIFIYNVGAEDNGTFSCVGQNIAG 351
                .||:  |:.              |.|:.:..|::            :|:|.:.|:..|.||
Mouse   452 ITTKSNGRATVLG--------------DGTLEIRFAQD------------QDSGMYVCIASNAAG 490

  Fly   352 TTFSNYTLRVIIK-----------EPPV------------VNEVSFPRDYMNYIVASSAGGGIIF 393
            .  ..:|..:.:|           ..|:            .|..:|..| :..|:.|:|.|...|
Mouse   491 N--DTFTASLTVKGFTSDRFLYANRTPMYMTDSNDTVSNGTNANTFSLD-LKTILVSTAMGCFTF 552

  Fly   394 --VVLLCTIVV 402
              |||.|.:::
Mouse   553 LGVVLFCFLLL 563

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek2	NP_523551.1	leucine-rich repeat	34..52	CDD:275380	6/17 (35%)
		leucine-rich repeat	54..79	CDD:275380	9/46 (20%)
		LRR_8	79..138	CDD:290566	22/111 (20%)
		LRR_RI	<80..187	CDD:238064	40/202 (20%)
		leucine-rich repeat	80..103	CDD:275380	7/22 (32%)
		leucine-rich repeat	104..127	CDD:275380	10/70 (14%)
		LRR_8	126..186	CDD:290566	22/107 (21%)
		leucine-rich repeat	128..151	CDD:275380	10/70 (14%)
		leucine-rich repeat	152..175	CDD:275380	8/22 (36%)
		leucine-rich repeat	176..198	CDD:275380	8/46 (17%)
		TPKR_C2	207..256	CDD:301599	15/55 (27%)
		I-set	258..361	CDD:254352	21/115 (18%)
		Ig_2	263..361	CDD:290606	20/110 (18%)
Lingo2	NP_001159471.1	LRRNT	27..60	CDD:214470	9/35 (26%)
		leucine-rich repeat	39..57	CDD:275380	6/17 (35%)
		LRR 1	58..79		7/20 (35%)
		leucine-rich repeat	59..82	CDD:275380	7/22 (32%)
		LRR_8	60..117	CDD:404697	12/56 (21%)
		LRR 2	82..103		2/20 (10%)
		leucine-rich repeat	83..106	CDD:275380	1/22 (5%)
		LRR_8	106..165	CDD:404697	15/58 (26%)
		LRR 3	106..127		6/20 (30%)
		leucine-rich repeat	107..130	CDD:275380	7/22 (32%)
		LRR 4	130..151		7/20 (35%)
		leucine-rich repeat	131..154	CDD:275380	6/22 (27%)
		LRR 5	154..175		0/20 (0%)
		leucine-rich repeat	155..178	CDD:275380	0/22 (0%)
		PPP1R42	176..>373	CDD:411060	42/200 (21%)
		LRR 6	178..199		4/20 (20%)
		leucine-rich repeat	179..202	CDD:275380	4/22 (18%)
		LRR 7	202..223		4/20 (20%)
		leucine-rich repeat	203..250	CDD:275380	4/46 (9%)
		LRR 8	226..247		0/20 (0%)
		LRR 9	250..271		4/20 (20%)
		leucine-rich repeat	251..274	CDD:275380	6/22 (27%)
		LRR 10	274..295		8/20 (40%)
		leucine-rich repeat	275..298	CDD:275380	8/22 (36%)
		LRR 11	298..319		4/20 (20%)
		leucine-rich repeat	299..322	CDD:275380	6/22 (27%)
		LRR 12	322..343		1/20 (5%)
		leucine-rich repeat	323..343	CDD:275380	1/19 (5%)
		LRRCT	355..408	CDD:214507	15/56 (27%)
		Ig	411..500	CDD:416386	20/116 (17%)
		Ig strand A'	417..421	CDD:409353	0/3 (0%)
		Ig strand B	427..436	CDD:409353	1/8 (13%)
		Ig strand C	441..446	CDD:409353	1/4 (25%)
		Ig strand C'	449..451	CDD:409353	0/1 (0%)
		Ig strand D	460..463	CDD:409353	0/2 (0%)
		Ig strand E	466..473	CDD:409353	1/6 (17%)
		Ig strand F	479..487	CDD:409353	2/7 (29%)
		Ig strand G	490..500	CDD:409353	2/11 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8825
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000