DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek2 and Lrrc4c

DIOPT Version :9

Sequence 1:	NP_523551.1	Gene:	kek2 / 34582	FlyBaseID:	FBgn0015400	Length:	894	Species:	Drosophila melanogaster
Sequence 2:	NP_001276671.1	Gene:	Lrrc4c / 241568	MGIID:	2442636	Length:	640	Species:	Mus musculus

Alignment Length:	515	Identity:	129/515 - (25%)
Similarity:	194/515 - (37%)	Gaps:	145/515 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 PIWIPLLALLAITAA-------CPPEVCVCKWKGGKQTVECGGQQLSNLPEGMDPGTQVLNFSGN 62
            |:.:.||||..:..|       | |.||.|..:..|  |.|..:.|..:|:|:...|::||...|
Mouse    25 PLLVVLLALQLLVVAGLVRAQTC-PSVCSCSNQFSK--VICVRKNLREVPDGISTNTRLLNLHEN 86

  Fly    63 ALQVLQSERFLRMDLLNLQKIYLSRNQLIRIHEKAFRGLTNLVELDLSENALQNVPSETFQDYSS 127
            .:|:::...|  ..|.:|:.:.||||.:..|...||.||.||..|:|.:|.|..:|:..|...|.
Mouse    87 QIQIIKVNSF--KHLRHLEILQLSRNHIRTIEIGAFNGLANLNTLELFDNRLTTIPNGAFVYLSK 149

  Fly   128 LMRLSLSGNPIRELKTSAFRHLSFLTTLELSNC-QVERIENEAFVGMDNLEWLR----------- 180
            |..|.|..|||..:.:.||..:..|..|:|... ::..|...||.|:.||.:|.
Mouse   150 LKELWLRNNPIESIPSYAFNRIPSLRRLDLGELKRLSYISEGAFEGLSNLRYLNLAMCNLREIPN 214

  Fly   181 -----------LDGN-----RIGFIQGTHILPK-------------------------------- 197
                       |.||     |.|..||...|.|
Mouse   215 LTPLIKLDELDLSGNHLSAIRPGSFQGLMHLQKLWMIQSQIQVIERNAFDNLQSLVEINLAHNNL 279

  Fly   198 ------------SLHGISLHSNRWNCDCRLLDIHFWLVNY---NTPLAEEPKCMEPARLKGQVIK 247
                        .|..|.||.|.|||:|.:|.:.:|:.:.   ||...  .:|..|..|||:.|.
Mouse   280 TLLPHDLFTPLHHLERIHLHHNPWNCNCDILWLSWWIRDMAPSNTACC--ARCNTPPNLKGRYIG 342

  Fly   248 SLQREQLAC-LPEVSPQSSYTEVSEGRNMSITCLVRAIPE-PKVLWLF-NGQVMSNDSLMDNLHM 309
            .|.:....| .|.:....:...|:||....:.|  ||... ..|.|:. ||.||::.:.  .:.:
Mouse   343 ELDQNYFTCYAPVIVEPPADLNVTEGMAAELKC--RASTSLTSVSWITPNGTVMTHGAY--KVRI 403

  Fly   310 YYYIDETIGVSGAEEKRSEIFIYNVGAEDNGTFSCVGQNIAGTTFSNYTLRVIIKEPPVVNEVSF 374
            ....|.|:..:            ||..:|.|.::|:..|..|.|.::.||.       |....:.
Mouse   404 AVLSDGTLNFT------------NVTVQDTGMYTCMVSNSVGNTTASATLN-------VTAATTT 449

  Fly   375 PRDYMNYIVASSAGGGIIFVVLLCTIVVKCKKTSEPAKQRKKCDQVTSIAGGTDSSTGST 434
            |..|.:                  |:.|   :|.||::..         |..||::.|.|
Mouse   450 PFSYFS------------------TVTV---ETMEPSQDE---------ARTTDNNVGPT 479

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek2	NP_523551.1	leucine-rich repeat	34..52	CDD:275380	5/17 (29%)
		leucine-rich repeat	54..79	CDD:275380	7/24 (29%)
		LRR_8	79..138	CDD:290566	23/58 (40%)
		LRR_RI	<80..187	CDD:238064	41/134 (31%)
		leucine-rich repeat	80..103	CDD:275380	10/22 (45%)
		leucine-rich repeat	104..127	CDD:275380	7/22 (32%)
		LRR_8	126..186	CDD:290566	22/87 (25%)
		leucine-rich repeat	128..151	CDD:275380	8/22 (36%)
		leucine-rich repeat	152..175	CDD:275380	7/23 (30%)
		leucine-rich repeat	176..198	CDD:275380	11/92 (12%)
		TPKR_C2	207..256	CDD:301599	16/51 (31%)
		I-set	258..361	CDD:254352	25/104 (24%)
		Ig_2	263..361	CDD:290606	24/99 (24%)
Lrrc4c	NP_001276671.1	LRRNT	47..80	CDD:214470	12/35 (34%)
		PPP1R42	65..235	CDD:411060	50/171 (29%)
		LRR 1	77..98		6/22 (27%)
		leucine-rich repeat	78..101	CDD:275380	7/24 (29%)
		LRR 2	101..122		8/20 (40%)
		leucine-rich repeat	102..125	CDD:275380	10/22 (45%)
		LRR 3	125..146		8/20 (40%)
		leucine-rich repeat	126..149	CDD:275380	7/22 (32%)
		LRR 4	149..170		8/20 (40%)
		leucine-rich repeat	150..173	CDD:275380	8/22 (36%)
		LRR 5	173..195		6/21 (29%)
		leucine-rich repeat	174..198	CDD:275380	7/23 (30%)
		LRR 6	198..219		3/20 (15%)
		leucine-rich repeat	199..220	CDD:275380	2/20 (10%)
		LRR_8	220..279	CDD:404697	9/58 (16%)
		LRR 7	220..241		5/20 (25%)
		leucine-rich repeat	221..244	CDD:275380	7/22 (32%)
		LRR 8	244..265		2/20 (10%)
		leucine-rich repeat	245..268	CDD:275380	2/22 (9%)
		LRR_8	267..>301	CDD:404697	4/33 (12%)
		LRR 9	268..289		0/20 (0%)
		leucine-rich repeat	269..290	CDD:275380	0/20 (0%)
		LRRCT	301..>339	CDD:214507	13/39 (33%)
		IG	360..443	CDD:214652	24/105 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	463..482		7/26 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8825
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910