DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment kek2 and FLRT1

DIOPT Version :9

Sequence 1:NP_523551.1 Gene:kek2 / 34582 FlyBaseID:FBgn0015400 Length:894 Species:Drosophila melanogaster
Sequence 2:NP_001371395.1 Gene:FLRT1 / 23769 HGNCID:3760 Length:674 Species:Homo sapiens


Alignment Length:306 Identity:70/306 - (22%)
Similarity:109/306 - (35%) Gaps:77/306 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    18 AACPPEVCVCKWKGGKQTVECGGQQLSNLPEGMDPGTQVLNFSGNALQVLQSERFLRMDLLNLQK 82
            |..|.::   |.|...|.:......|...|..:....:.|:...|.::.:..:...|:.|  |:|
Human    96 AGIPQDL---KTKVNVQVIYLYENDLDEFPINLPRSLRELHLQDNNVRTIARDSLARIPL--LEK 155

  Fly    83 IYLSRNQL--IRIHEKAF--------------------RGLTN-LVELDLSENALQNVPSETFQD 124
            ::|..|.:  :.|.|.||                    .||.: |.||.|.:|.:..:|...|:.
Human   156 LHLDDNSVSTVSIEEDAFADSKQLKLLFLSRNHLSSIPSGLPHTLEELRLDDNRISTIPLHAFKG 220

  Fly   125 YSSLMRLSLSGNPI--RELKTSAFRHLSFLTTLE----------------------LSNCQVERI 165
            .:||.||.|.||.:  :.:....|..|..||.|.                      |.:..:..|
Human   221 LNSLRRLVLDGNLLANQRIADDTFSRLQNLTELSLVRNSLAAPPLNLPSAHLQKLYLQDNAISHI 285

  Fly   166 ENEAFVGMDNLEWLRLDGNRIGFIQGTHILPKSLHG-------ISLHSNRWNCDCRLLDIHFW-- 221
            .......|..||.|.|..|.:      ..||:.|..       :.|.:|.|.|.|.|:.:..|  
Human   286 PYNTLAKMRELERLDLSNNNL------TTLPRGLFDDLGNLAQLLLRNNPWFCGCNLMWLRDWVK 344

  Fly   222 ----LVNYNTPLAEEPKCMEPARLKGQVIKSLQREQLACLPEVSPQ 263
                :||....:     |..|.:::|..||.:..|...|. |..||
Human   345 ARAAVVNVRGLM-----CQGPEKVRGMAIKDITSEMDECF-ETGPQ 384

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kek2NP_523551.1 leucine-rich repeat 34..52 CDD:275380 3/17 (18%)
leucine-rich repeat 54..79 CDD:275380 4/24 (17%)
LRR_8 79..138 CDD:290566 24/81 (30%)
LRR_RI <80..187 CDD:238064 37/153 (24%)
leucine-rich repeat 80..103 CDD:275380 10/44 (23%)
leucine-rich repeat 104..127 CDD:275380 7/22 (32%)
LRR_8 126..186 CDD:290566 20/83 (24%)
leucine-rich repeat 128..151 CDD:275380 8/24 (33%)
leucine-rich repeat 152..175 CDD:275380 6/44 (14%)
leucine-rich repeat 176..198 CDD:275380 7/21 (33%)
TPKR_C2 207..256 CDD:301599 14/54 (26%)
I-set 258..361 CDD:254352 3/6 (50%)
Ig_2 263..361 CDD:290606 1/1 (100%)
FLRT1NP_001371395.1 PRK15370 <58..>329 CDD:185268 52/243 (21%)
leucine-rich repeat 108..128 CDD:275380 3/19 (16%)
leucine-rich repeat 129..152 CDD:275380 3/22 (14%)
leucine-rich repeat 153..178 CDD:275380 8/24 (33%)
leucine-rich repeat 179..199 CDD:275380 2/19 (11%)
leucine-rich repeat 200..223 CDD:275380 7/22 (32%)
leucine-rich repeat 224..249 CDD:275380 8/24 (33%)
leucine-rich repeat 250..271 CDD:275380 3/20 (15%)
leucine-rich repeat 272..295 CDD:275380 3/22 (14%)
leucine-rich repeat 296..319 CDD:275380 8/28 (29%)
PCC 300..>406 CDD:188093 24/97 (25%)
FN3 441..505 CDD:214495
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
00.000

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