DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kek2 and Lingo3

DIOPT Version :9

Sequence 1:	NP_523551.1	Gene:	kek2 / 34582	FlyBaseID:	FBgn0015400	Length:	894	Species:	Drosophila melanogaster
Sequence 2:	NP_001013780.2	Gene:	Lingo3 / 237403	MGIID:	3609246	Length:	589	Species:	Mus musculus

Alignment Length:	580	Identity:	125/580 - (21%)
Similarity:	198/580 - (34%)	Gaps:	221/580 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 WIPLLAL-------LAITAACPPEVCVCKWKGGKQTVECGGQQLSNLPEG--------------- 49
            |:.:|.|       ..:.|.||..   |:.....:||.||.::|:.:|||
Mouse     4 WLHMLGLHLLLLPTAPLAAGCPAR---CECSASTRTVACGRRRLTAIPEGIPAETRMLELSRNRI 65

  Fly    50 --------------------------MDPGT-------QVLNFSGNALQVLQSERFLRM------ 75
                                      ::||.       :||...||.|:::....|..:
Mouse    66 RCLNPGDLASLPTLEELDLNHNVIAHVEPGAFANLPRLRVLRLRGNQLKLIPPGVFTHLDSLTLL 130

  Fly    76 ----------------DLLNLQKIYLSRNQLIRIHEKAFRGLTNLVEL--------DLSENAL-- 114
                            ||.:||::.:..|.|:.|..:||.||..|.||        .||..:|
Mouse   131 DLSENKLVILLDFSFQDLRSLQRLEVGDNDLVFISRRAFAGLLGLAELTLERCNLTSLSPESLGH 195

  Fly   115 -------------------QN-------------------------------------------V 117
                               ||                                           |
Mouse   196 LRGLGALRLRHLAIAALEDQNFQKLPGLSHLEIDNWPLLEEVAPGSLRGLNLTSLSITHTNITAV 260

  Fly   118 PSETFQDYSSLMRLSLSGNPIRELKTSAFRHLSFLTTLELSNCQVERIENEAFVGMDNLEWLRLD 182
            |:...:..:.|..|:||.|||..:...:||.|..|..|.|:...:..||.:||||:..:..|.|.
Mouse   261 PAAALRQQAHLTCLNLSHNPISMVPRGSFRDLVRLRELHLAGALLAVIEPQAFVGLRQIRLLNLS 325

  Fly   183 GNRIGFI-QGTHILPKSLHGISLHSNRWNCDCRLLDIHFWLV------NYNTPLAEEPKCMEPAR 240
            .|.:..: :.|.....:|..:.:..|...||||||    |:|      |::..|   |.|..||.
Mouse   326 DNLLSTLEENTFHSVNTLETLRVDGNPLACDCRLL----WIVQRRKTLNFDGRL---PACATPAE 383

  Fly   241 LKGQVIKSLQR----EQLAC-LPEVSPQS-SYTEVSEGRNMSITCLVRAIPEPKVLWLFNGQVMS 299
            ::|..:.:|..    |...| .|::..:. .:...:||.::...|.....|.|.|.|:
Mouse   384 VRGDALHNLPDSVLFEYFVCRKPKIRERRLQHVTATEGDDVRFLCRAEGEPAPTVAWV------- 441

  Fly   300 NDSLMDNLHMYYYIDETIGVSGAEEKRSEIF------IYNVGAEDNGTFSCVGQNIAG--TTFSN 356
                         ..:...|:.|...|:.:.      |.:...:|:||::||..|..|  |.|:.
Mouse   442 -------------TPQHHSVTAASRGRARVLPGGTLTIADTRPQDSGTYTCVASNAGGNDTYFAT 493

  Fly   357 YTLRVIIKEPPVVNE------------VSFPRDYMNYIVASSAGGGIIF--VVLLCTIVV 402
            .|::      |..|.            |.||.| :..|:.|:|.|.|.|  |||.|.:::
Mouse   494 LTVQ------PAANRTQGDGHNETQVGVRFPLD-LTTILVSTAMGCITFLGVVLFCFLLL 546

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek2	NP_523551.1	leucine-rich repeat	34..52	CDD:275380	8/58 (14%)
		leucine-rich repeat	54..79	CDD:275380	8/53 (15%)
		LRR_8	79..138	CDD:290566	24/130 (18%)
		LRR_RI	<80..187	CDD:238064	41/178 (23%)
		leucine-rich repeat	80..103	CDD:275380	9/22 (41%)
		leucine-rich repeat	104..127	CDD:275380	10/94 (11%)
		LRR_8	126..186	CDD:290566	22/59 (37%)
		leucine-rich repeat	128..151	CDD:275380	10/22 (45%)
		leucine-rich repeat	152..175	CDD:275380	9/22 (41%)
		leucine-rich repeat	176..198	CDD:275380	4/22 (18%)
		TPKR_C2	207..256	CDD:301599	18/58 (31%)
		I-set	258..361	CDD:254352	22/111 (20%)
		Ig_2	263..361	CDD:290606	21/106 (20%)
Lingo3	NP_001013780.2	LRRNT	23..55	CDD:214470	11/34 (32%)
		leucine-rich repeat	34..53	CDD:275380	8/18 (44%)
		LRR 1	54..75		0/20 (0%)
		LRR	<55..353	CDD:227223	54/297 (18%)
		leucine-rich repeat	55..78	CDD:275380	0/22 (0%)
		LRR 2	78..99		2/20 (10%)
		leucine-rich repeat	79..102	CDD:275380	2/22 (9%)
		LRR 3	102..123		6/20 (30%)
		leucine-rich repeat	103..150	CDD:275380	8/46 (17%)
		LRR 4	126..147		0/20 (0%)
		LRR 5	150..171		7/20 (35%)
		leucine-rich repeat	151..174	CDD:275380	9/22 (41%)
		LRR 6	174..195		6/20 (30%)
		leucine-rich repeat	175..198	CDD:275380	6/22 (27%)
		leucine-rich repeat	199..222	CDD:275380	2/22 (9%)
		LRR 7	206..227		2/20 (10%)
		leucine-rich repeat	223..246	CDD:275380	0/22 (0%)
		LRR_8	246..302	CDD:338972	15/55 (27%)
		LRR 8	246..267		2/20 (10%)
		leucine-rich repeat	247..270	CDD:275380	2/22 (9%)
		LRR 9	270..291		8/20 (40%)
		leucine-rich repeat	271..292	CDD:275380	9/20 (45%)
		LRR 10	294..315		7/20 (35%)
		leucine-rich repeat	295..318	CDD:275380	9/22 (41%)
		LRR 11	318..339		4/20 (20%)
		leucine-rich repeat	321..342	CDD:275380	4/20 (20%)
		PCC	331..>405	CDD:188093	21/80 (26%)
		I-set	406..496	CDD:369462	21/109 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8825
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910