DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek2 and Lingo1

DIOPT Version :9

Sequence 1:	NP_523551.1	Gene:	kek2 / 34582	FlyBaseID:	FBgn0015400	Length:	894	Species:	Drosophila melanogaster
Sequence 2:	XP_006511149.1	Gene:	Lingo1 / 235402	MGIID:	1915522	Length:	647	Species:	Mus musculus

Alignment Length:	588	Identity:	123/588 - (20%)
Similarity:	195/588 - (33%)	Gaps:	217/588 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LPIWIPLLALL------AITAACPPEVCVCKWKGGKQTVECGGQQLSNLPEGMDPGTQVLNFSGN 62
            |..|.|:|.|:      .....|||.   |:.....:.|.|..::...:|||:...|::|:...|
Mouse    47 LACWQPILLLVLGSVLSGSATGCPPR---CECSAQDRAVLCHRKRFVAVPEGIPTETRLLDLGKN 108

  Fly    63 ALQVLQSERFLRM----------------------DLLNLQKIYLSRNQLIRIHEKAFRGLTNLV 105
            .::.|..:.|...                      :|.||:.:.|..|:|..|....|.||:||.
Mouse   109 RIKTLNQDEFASFPHLEELELNENIVSAVEPGAFNNLFNLRTLGLRSNRLKLIPLGVFTGLSNLT 173

  Fly   106 ELDLSENALQNVPSETFQDYSSLMRLSLSGNP--------------------------------- 137
            :||:|||.:..:....|||..:|..|.:..|.
Mouse   174 KLDISENKIVILLDYMFQDLYNLKSLEVGDNDLVYISHRAFSGLNSLEQLTLEKCNLTSIPTEAL 238

  Fly   138 ----------IRELKTSAFRHLSF-----------------------------LTTLELSNCQVE 163
                      :|.|..:|.|..||                             ||:|.:::|.:.
Mouse   239 SHLHGLIVLRLRHLNINAIRDYSFKRLYRLKVLEISHWPYLDTMTPNCLYGLNLTSLSITHCNLT 303

  Fly   164 RIENEAFVGMDNLEWLRLDGNRIGFIQGT--HIL-----------------PKSLHGIS------ 203
            .:...|...:..|.:|.|..|.||.|:|:  |.|                 |.:..|::
Mouse   304 AVPYLAVRHLVYLRFLNLSYNPIGTIEGSMLHELLRLQEIQLVGGQLAVVEPYAFRGLNYLRVLN 368

  Fly   204 ------------------------LHSNRWNCDCRLLDI--HFWLVNYNTPLAEEPKCMEPARLK 242
                                    |.||...||||||.:  ..|.:|:|   .::|.|..|..::
Mouse   369 VSGNQLTTLEESAFHSVGNLETLILDSNPLACDCRLLWVFRRRWRLNFN---RQQPTCATPEFVQ 430

  Fly   243 GQVIKSLQREQLACLPEVSPQSSYT--------------EVSEGRNMSITCLVRAIPEPKVLWLF 293
            |:..|.        .|:|...:.:|              .|.||..:...|.....|.|.:|||.
Mouse   431 GKEFKD--------FPDVLLPNYFTCRRAHIRDRKAQQVFVDEGHTVQFVCRADGDPPPAILWLS 487

  Fly   294 NGQVMSNDSLMDNLHMYYYIDETIGVSGAEEKRSEIFIYNVGAEDNGTFSCVGQNIAGT------ 352
            ..:.:.  |...|..:..:.|.|:.|..|:            .:||||:.|:..|..|.
Mouse   488 PRKHLV--SAKSNGRLTVFPDGTLEVRYAQ------------VQDNGTYLCIAANAGGNDSMPAH 538

  Fly   353 ----TFS-------NYTLRVIIKEP------PVVNEVSFPRDYMNYIVASSAGG-GIIFVVLLCT 399
                ::|       |.|...|..:|      .....|.||.|....|:|::.|. ..:.|||.|.
Mouse   539 LHVRSYSPDWPHQPNKTFAFISNQPGEGEANSTRATVPFPFDIKTLIIATTMGFISFLGVVLFCL 603

  Fly   400 IVV 402
            :::
Mouse   604 VLL 606

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek2	NP_523551.1	leucine-rich repeat	34..52	CDD:275380	5/17 (29%)
		leucine-rich repeat	54..79	CDD:275380	6/46 (13%)
		LRR_8	79..138	CDD:290566	22/101 (22%)
		LRR_RI	<80..187	CDD:238064	36/178 (20%)
		leucine-rich repeat	80..103	CDD:275380	8/22 (36%)
		leucine-rich repeat	104..127	CDD:275380	9/22 (41%)
		LRR_8	126..186	CDD:290566	18/131 (14%)
		leucine-rich repeat	128..151	CDD:275380	7/65 (11%)
		leucine-rich repeat	152..175	CDD:275380	5/22 (23%)
		leucine-rich repeat	176..198	CDD:275380	11/40 (28%)
		TPKR_C2	207..256	CDD:301599	15/50 (30%)
		I-set	258..361	CDD:254352	28/133 (21%)
		Ig_2	263..361	CDD:290606	26/128 (20%)
Lingo1	XP_006511149.1	LRRNT	68..102	CDD:214470	10/36 (28%)
		LRR	<93..398	CDD:227223	57/304 (19%)
		leucine-rich repeat	100..123	CDD:275380	5/22 (23%)
		leucine-rich repeat	124..147	CDD:275380	1/22 (5%)
		LRR_8	147..206	CDD:338972	22/58 (38%)
		leucine-rich repeat	148..171	CDD:275380	8/22 (36%)
		leucine-rich repeat	172..219	CDD:275380	12/46 (26%)
		leucine-rich repeat	220..243	CDD:275380	0/22 (0%)
		leucine-rich repeat	244..291	CDD:275380	6/46 (13%)
		leucine-rich repeat	292..315	CDD:275380	5/22 (23%)
		leucine-rich repeat	316..339	CDD:275380	10/22 (45%)
		leucine-rich repeat	340..363	CDD:275380	2/22 (9%)
		leucine-rich repeat	364..384	CDD:275380	0/19 (0%)
		PCC	368..>448	CDD:188093	19/90 (21%)
		Ig	466..541	CDD:386229	20/88 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8825
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000