Protein Alignment kek2 and Amigo1

DIOPT Version :10

• Sequence 1: NP_523551.1
• Gene: kek2 / 34582
• FlyBaseID: FBgn0015400
• Length: 894
• Species: Drosophila melanogaster
• Sequence 2: NP_666249.2
• Gene: Amigo1 / 229715
• MGIID: 2653612
• Length: 492
• Species: Mus musculus
• Alignment Length: 503
• Identity: 133/503 - (26%)
• Similarity: 208/503 - (41%)
• Gaps: 76/503 - (15%)

  Fly     6 IWIPLLALLAI----------TAACPPEVCVCKWKGGKQTVECGGQQLSNLPEGMDPGTQVLNFS 60
            :|:.||::..:          ..:||.. |:|    ....:.|..|||.|:|:.:...|.:|:.|
Mouse    10 LWLLLLSVFLLLFEVARAGRSVVSCPAN-CLC----ASNILSCSKQQLPNVPQSLPSYTALLDLS 69

  Fly    61 GNALQVLQSERFLRMDLLNLQKIYLSRNQLIRIHEKAFRGLTNLVELDLSENALQNVPSETFQDY 125
            .|.|..|::| :....|.||..:.||.|.|..|..:||..:.||..||||.|.|..:....|.|.
Mouse    70 HNNLSRLRAE-WTPTRLTNLHSLLLSHNHLNFISSEAFVPVPNLRYLDLSSNHLHTLDEFLFSDL 133

  Fly   126 SSLMRLSLSGNPIRELKTSAFRHLSFLTTLELSNCQVERIENEAFVG---MDNLEWLRLDGNRIG 187
            .:|..|.|..|.|..:..:||..::.|..|.||..|:.|...|....   :..|..|.|..|::.
Mouse   134 QALEVLLLYNNHIVVVDRNAFEDMAQLQKLYLSQNQISRFPVELIKDGNKLPKLMLLDLSSNKLK 198

  Fly   188 FIQGTHI--LPKSL-HGISLHSNRWNCDCRLLDI--HFWLVNYNTPL--AEEPKCMEPARLKGQV 245
            .:..|.:  ||..: :|:.||:|...|||:|..:  |:.....::.:  .|:..||...:|..
Mouse   199 KLPLTDLQKLPAWVKNGLYLHNNPLECDCKLYQLFSHWQYRQLSSVMDFQEDLYCMHSKKLHN-- 261

  Fly   246 IKSLQREQLACLPEVSPQSSYTEVSEGRNMSITCLVRAIPEPKVLWL--FNGQVMSNDSLMDNLH 308
            |.||.....:...|     |..|...|..::|.|..:.....|| |:  .|.||:|.
Mouse   262 IFSLDFFNCSEYKE-----SAWEAHLGDTLTIRCDTKQQGMTKV-WVSPSNEQVLSQ-------- 312

  Fly   309 MYYYIDETIGVSGAEEKRS-EIFIYNVGAEDNGTFSCVGQNIAGTTFSNYTLRVIIKEPPVVN-E 371
                     |.:|:...|: ::|...|..||.|.::|...   |.|| |.||.|.:|   |.| .
Mouse   313 ---------GSNGSVSVRNGDLFFKKVQVEDGGVYTCYAM---GETF-NETLSVELK---VYNFT 361

  Fly   372 VSFPRDYMNYIVASSAGGGIIFVVLLCTIVVK-----CKKTSEPAKQRKKCDQVTSIAGGT---- 427
            :....|.:|....:..|..:..|::|..:.:.     |:...:|:..:.  |.::|....|
Mouse   362 LHGHHDTLNTAYTTLVGCILSVVLVLIYLYLTPCRCWCRGVEKPSSHQG--DSLSSSMLSTTPNH 424

  Fly   428 DSSTGSTQDTGMGMMKCASILNDGGDSMNGNPGLLLGDTLTPTKAANG 475
            |...|..:|.|..  :..:.|...|.....|..|..|:|| |...|.|
Mouse   425 DPMAGGDKDDGFD--RRVAFLEPAGPGQGQNGKLKPGNTL-PVPEATG 469

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kek2	NP_523551.1	LRR	<34..>204	CDD:443914	55/175 (31%)
		leucine-rich repeat	34..52	CDD:275380	6/17 (35%)
		leucine-rich repeat	54..79	CDD:275380	8/24 (33%)
		leucine-rich repeat	80..103	CDD:275380	8/22 (36%)
		leucine-rich repeat	104..127	CDD:275380	9/22 (41%)
		leucine-rich repeat	128..151	CDD:275380	7/22 (32%)
		leucine-rich repeat	152..175	CDD:275380	7/25 (28%)
		leucine-rich repeat	176..198	CDD:275380	7/23 (30%)
		LRRCT	207..256	CDD:214507	13/52 (25%)
		Ig_3	258..348	CDD:464046	22/92 (24%)
Amigo1	NP_666249.2	leucine-rich repeat	44..64	CDD:275380	6/19 (32%)
		LRR 1. /evidence=ECO:0000269|PubMed:21983541	62..83		7/21 (33%)
		leucine-rich repeat	65..87	CDD:275380	7/22 (32%)
		LRR	<66..>224	CDD:443914	51/158 (32%)
		LRR 2. /evidence=ECO:0000269|PubMed:21983541	87..108		9/20 (45%)
		leucine-rich repeat	88..111	CDD:275380	8/22 (36%)
		LRR 3. /evidence=ECO:0000269|PubMed:21983541	111..132		9/20 (45%)
		leucine-rich repeat	112..135	CDD:275380	9/22 (41%)
		LRR 4. /evidence=ECO:0000269|PubMed:21983541	135..156		7/20 (35%)
		leucine-rich repeat	136..159	CDD:275380	7/22 (32%)
		LRR 5. /evidence=ECO:0000269|PubMed:21983541	159..180		7/20 (35%)
		leucine-rich repeat	160..186	CDD:275380	7/25 (28%)
		LRR 6. /evidence=ECO:0000269|PubMed:21983541	186..206		5/19 (26%)
		leucine-rich repeat	187..210	CDD:275380	6/22 (27%)
		IG_like	279..357	CDD:214653	28/102 (27%)
		Ig strand E	323..327	CDD:409512	0/3 (0%)
		Ig strand F	337..342	CDD:409512	1/4 (25%)
		Ig strand G	351..354	CDD:409512	1/2 (50%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	404..492		18/71 (25%)