DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek2 and pxn-1

DIOPT Version :9

Sequence 1:	NP_523551.1	Gene:	kek2 / 34582	FlyBaseID:	FBgn0015400	Length:	894	Species:	Drosophila melanogaster
Sequence 2:	NP_505188.3	Gene:	pxn-1 / 191484	WormBaseID:	WBGene00004256	Length:	1285	Species:	Caenorhabditis elegans

Alignment Length:	881	Identity:	176/881 - (19%)
Similarity:	265/881 - (30%)	Gaps:	352/881 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LLALLAITAA--------CPPEVCVCKWKGGKQTVECGGQQLSNLPEGMDPGTQVLNFSGNALQV 66
            ||.|:..|::        ||.| |.|..||  ..|:|....|:.:|:.:....:.|....|.:..
Worm     5 LLLLVIATSSWQFVAGLECPVE-CTCDKKG--LVVDCSSSGLTRIPKNISRNVRSLVIRNNRIHK 66

  Fly    67 LQSERFLRMDL---LNLQKIYLSRNQLIRIHEKAFRGLTNLVELDLSENALQNVPSETFQDYSSL 128
            |:     |.||   ..|:.:.|:.|::..|.|.....|..|..|.|:.|.|..:| ....|...|
Worm    67 LK-----RSDLEGFNQLETLVLTHNKIKIIEENVLDHLPELKRLSLAHNELVYIP-PLCSDSRPL 125

  Fly   129 MRLSLSGNPIRELKTSAFRHLSFLTTLELSNCQVERIENEAFVGMDNLEWLRLDGNRIGFIQGTH 193
            ..|:|..|.|:.:.....|:...||.|:.|:.:::.:..:.|   ||
Worm   126 ASLNLKRNHIQFIDEQVLRYFPDLTQLDFSHNRIQSLRTKLF---DN------------------ 169

  Fly   194 ILPKSLHGISLHSNRWNCDCR------LLDIHFWLVNYNTPLAEEPK--CMEPARLKGQVIKSLQ 250
             ||...|. .||||.|:||||      ||....|          |.|  |..|..|:.|.:..:.
Worm   170 -LPALSHA-HLHSNPWHCDCRASKVKALLQKVKW----------EKKVYCTNPVELRHQALDEVD 222

  Fly   251 REQLAC----------------------------------------------------------- 256
            ...|.|
Worm   223 DSALTCARPAEESWTGEEIKLTCAKNSSSKLVVWMYENVEVDSSSLDGYEIHDTVITVPRKTNVN 287

  Fly   257 ----------LP------------EVSPQSSY----TEVSEGRNMSITCLVRAIPEPKVLWLFNG 295
                      :|            ..|||.:|    ....||..:.:.|.|...|:|.:.|..||
Worm   288 FMTCTYDFDHIPHHRRLRQSQHQGNGSPQFTYKPRDNSFREGSEVKVNCEVMGNPKPTINWYHNG 352

  Fly   296 QVMSNDSLMDNLHMYYYIDETIGVSGAEEKRSEIFIYNVGAEDNGTFSCVGQNIAGTTFSNYTLR 360
            :...:..           ...:|:|     .:.:.||....||:|.::|...|..|.....::|.
Worm   353 KRFISSR-----------KRQLGLS-----NNVLRIYPFLEEDSGRYTCEAVNSVGKVRHAFSLD 401

  Fly   361 VIIKEPPVVNEVSFPRDYMNYIVASSAGGGIIFVVLLCTIVVKCKKTSEPAKQRKKCDQVTSIAG 425
            :|...||.:.|  .|:.     |:.:.||.::||         ||....|            :..
Worm   402 LISSVPPNIYE--GPQS-----VSQNLGGSVVFV---------CKANGNP------------VPD 438

  Fly   426 GTDSSTGSTQDTGMGMMKCASILNDGG----------------DSMNGNP-GLLLGDT-LTPTKA 472
            .|.|..|||    :|.:|...:::|.|                ..|.||| |.:..|. ||
Worm   439 YTWSFDGST----IGHIKGRFMVSDDGTELRISNIEKKDEGYYSCMAGNPVGAMSADAKLT---- 495

  Fly   473 ANGAAGGGIILGNQMKQ-------NLLLYATPNSAQQQLQLNVNLMGTGPGSPPLLLSNGHGLAA 530
                     ::|.:.::       ..||.|....|:|.::..|.
Worm   496 ---------VIGGETRKAAAPQIDEELLRAIAQKARQNVENAVE--------------------- 530

  Fly   531 AYCSPPASLRNYQEKNPDLVNDAESVKHKL-----KTAVSLDGAGEYETQSDCGQYEGCYQLAAA 590
                     :..::...|.|.:...:|...     |.||.|..|.|.        ||...:|.
Worm   531 ---------KTRKQLTQDKVTNTNDLKRLFRFSTPKQAVELSKAREI--------YEESVRLV-- 576

  Fly   591 PHPHQGHQHPHPG--------HPLMGRFAQAMTTLPRGMQLKPAPHQVDVHLNPV--------CF 639
                  .:|...|        ||                  |...::..:|:..|        |.
Worm   577 ------REHVEKGLILNVDELHP------------------KNVSYESVLHVTHVQALMGLSGCH 617

  Fly   640 LGQ------DGSFAYDYSSAHMVQQPPQQQQQQQQVQPANNFYRTLPHNRLHKQQQFQAAAAAGG 698
            .||      |..|.:.|.|.        ..|...:.:|... ...:|..||.|     .....|.
Worm   618 TGQYKNPCTDTCFHHRYRSF--------DGQCNNKNKPMTG-VSLMPLRRLLK-----PVYENGF 668

  Fly   699 NVGVGGNPTLRYSLEAEFIQRGPTVSYEKYQLPNVR 734
            |..||.             ::|..  |..|.|||||
Worm   669 NTPVGW-------------EKGRL--YNGYPLPNVR 689

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek2	NP_523551.1	leucine-rich repeat	34..52	CDD:275380	4/17 (24%)
		leucine-rich repeat	54..79	CDD:275380	6/27 (22%)
		LRR_8	79..138	CDD:290566	17/58 (29%)
		LRR_RI	<80..187	CDD:238064	26/106 (25%)
		leucine-rich repeat	80..103	CDD:275380	6/22 (27%)
		leucine-rich repeat	104..127	CDD:275380	7/22 (32%)
		LRR_8	126..186	CDD:290566	13/59 (22%)
		leucine-rich repeat	128..151	CDD:275380	6/22 (27%)
		leucine-rich repeat	152..175	CDD:275380	5/22 (23%)
		leucine-rich repeat	176..198	CDD:275380	2/21 (10%)
		TPKR_C2	207..256	CDD:301599	16/56 (29%)
		I-set	258..361	CDD:254352	25/118 (21%)
		Ig_2	263..361	CDD:290606	22/101 (22%)
pxn-1	NP_505188.3	LRRNT	23..51	CDD:279764	11/30 (37%)
		leucine-rich repeat	35..53	CDD:275380	4/17 (24%)
		LRR_8	52..112	CDD:290566	16/64 (25%)
		LRR_4	53..93	CDD:289563	10/44 (23%)
		leucine-rich repeat	54..77	CDD:275380	6/27 (22%)
		LRR_4	77..120	CDD:289563	12/43 (28%)
		leucine-rich repeat	78..101	CDD:275380	6/22 (27%)
		leucine-rich repeat	102..117	CDD:275380	6/15 (40%)
		LRR_8	123..182	CDD:290566	19/81 (23%)
		leucine-rich repeat	125..148	CDD:275380	6/22 (27%)
		leucine-rich repeat	149..172	CDD:275380	8/44 (18%)
		I-set	315..400	CDD:254352	22/100 (22%)
		IGc2	328..392	CDD:197706	18/79 (23%)
		IG_like	414..496	CDD:214653	26/124 (21%)
		Ig	420..496	CDD:299845	24/113 (21%)
		An_peroxidase	634..1181	CDD:281139	20/85 (24%)
		peroxidasin_like	757..1203	CDD:188658
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910