Protein Alignment kek2 and LINGO2

DIOPT Version :10

• Sequence 1: NP_523551.1
• Gene: kek2 / 34582
• FlyBaseID: FBgn0015400
• Length: 894
• Species: Drosophila melanogaster
• Sequence 2: NP_689783.1
• Gene: LINGO2 / 158038
• HGNCID: 21207
• Length: 606
• Species: Homo sapiens
• Alignment Length: 596
• Identity: 121/596 - (20%)
• Similarity: 203/596 - (34%)
• Gaps: 231/596 - (38%)

  Fly     2 SGLPIWIPLLALLAI------TAACPPEVCVCKWKGGKQTVECGGQQLSNLPEGMDPGTQVLNFS 60
            :.:..|.|.|.|..:      |..||..   |:.....::|.|..::|..:|||:...|::|:.|
Human     4 TAISCWQPFLGLAVVLIFMGSTIGCPAR---CECSAQNKSVSCHRRRLIAIPEGIPIETKILDLS 65

  Fly    61 GNALQVLQSERFLRMDLL----------------------NLQKIYLSRNQLIRIHEKAFRGLTN 103
            .|.|:.:..|.|:...||                      ||:.:.|..|:|..:....|.||:|
Human    66 KNRLKSVNPEEFISYPLLEEIDLSDNIIANVEPGAFNNLFNLRSLRLKGNRLKLVPLGVFTGLSN 130

  Fly   104 LVELDLSENA------------------------------------------------LQNVPSE 120
            |.:||:|||.                                                |..||:|
Human   131 LTKLDISENKIVILLDYMFQDLHNLKSLEVGDNDLVYISHRAFSGLLSLEQLTLEKCNLTAVPTE 195

  Fly   121 TFQDYSSLM-----RLSLSGNPIRELK-----------------------------TS------- 144
            ......||:     .|:::..|:...|                             ||
Human   196 ALSHLRSLISLHLKHLNINNMPVYAFKRLFHLKHLEIDYWPLLDMMPANSLYGLNLTSLSVTNTN 260

  Fly   145 -------AFRHLSFLTTLELSNCQVERIENEAFVGMDNLEWLRLDGNRIGFI-----QGTHIL-- 195
                   ||:||.:||.|.||...:..||...|..:..|:.|.:.|.::..|     ||...|
Human   261 LSTVPFLAFKHLVYLTHLNLSYNPISTIEAGMFSDLIRLQELHIVGAQLRTIEPHSFQGLRFLRV 325

  Fly   196 ------------------PKSLHGISLHSNRWNCDCRLLDIHFWLVNYNTPL---AEEPKCMEPA 239
                              |::|..:|:::|...||||||    |::.....|   .::|.|..|.
Human   326 LNVSQNLLETLEENVFSSPRALEVLSINNNPLACDCRLL----WILQRQPTLQFGGQQPMCAGPD 386

  Fly   240 RLKGQVIKSLQREQLA----C-LPEVSPQS-SYTEVSEGRNMSITCLVRAIPEPKVLWL------ 292
            .::.:..|......|:    | .|::..:. .:..|.||:.:.:.|.....|:|.:.|:
Human   387 TIRERSFKDFHSTALSFYFTCKKPKIREKKLQHLLVDEGQTVQLECSADGDPQPVISWVTPRRRF 451

  Fly   293 ----FNGQ--VMSNDSLMDNLHMYYYIDETIGVSGAEEKRSEIFIYNVGAEDNGTFSCVGQNIAG 351
                .||:  |:.              |.|:.:..|::            :|:|.:.|:..|.||
Human   452 ITTKSNGRATVLG--------------DGTLEIRFAQD------------QDSGMYVCIASNAAG 490

  Fly   352 TTFSNYTLRVIIK-----------EPPV------------VNEVSFPRDYMNYIVASSAGGGIIF 393
            .  ..:|..:.:|           ..|:            .|..:|..| :..|:.|:|.|...|
Human   491 N--DTFTASLTVKGFASDRFLYANRTPMYMTDSNDTISNGTNANTFSLD-LKTILVSTAMGCFTF 552

  Fly   394 --VVLLCTIVV 402
              |||.|.:::
Human   553 LGVVLFCFLLL 563

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kek2	NP_523551.1	LRR	<34..>204	CDD:443914	62/312 (20%)
		leucine-rich repeat	34..52	CDD:275380	6/17 (35%)
		leucine-rich repeat	54..79	CDD:275380	9/46 (20%)
		leucine-rich repeat	80..103	CDD:275380	7/22 (32%)
		leucine-rich repeat	104..127	CDD:275380	10/70 (14%)
		leucine-rich repeat	128..151	CDD:275380	10/70 (14%)
		leucine-rich repeat	152..175	CDD:275380	8/22 (36%)
		leucine-rich repeat	176..198	CDD:275380	8/46 (17%)
		LRRCT	207..256	CDD:214507	14/55 (25%)
		Ig_3	258..348	CDD:464046	17/102 (17%)
LINGO2	NP_689783.1	LRRNT	27..60	CDD:214470	9/35 (26%)
		leucine-rich repeat	39..57	CDD:275380	6/17 (35%)
		LRR	48..>340	CDD:443914	58/291 (20%)
		LRR 1	58..79		7/20 (35%)
		leucine-rich repeat	59..82	CDD:275380	7/22 (32%)
		LRR 2	82..103		2/20 (10%)
		leucine-rich repeat	83..106	CDD:275380	1/22 (5%)
		LRR 3	106..127		6/20 (30%)
		leucine-rich repeat	107..130	CDD:275380	7/22 (32%)
		LRR 4	130..151		7/20 (35%)
		leucine-rich repeat	131..154	CDD:275380	6/22 (27%)
		LRR 5	154..175		0/20 (0%)
		leucine-rich repeat	155..178	CDD:275380	0/22 (0%)
		LRR 6	178..199		4/20 (20%)
		leucine-rich repeat	179..202	CDD:275380	4/22 (18%)
		LRR 7	202..223		4/20 (20%)
		leucine-rich repeat	203..250	CDD:275380	4/46 (9%)
		LRR 8	226..247		0/20 (0%)
		LRR 9	250..271		4/20 (20%)
		leucine-rich repeat	251..274	CDD:275380	6/22 (27%)
		LRR 10	274..295		8/20 (40%)
		leucine-rich repeat	275..298	CDD:275380	8/22 (36%)
		LRR 11	298..319		4/20 (20%)
		leucine-rich repeat	299..322	CDD:275380	6/22 (27%)
		LRR 12	322..343		1/20 (5%)
		leucine-rich repeat	323..343	CDD:275380	1/19 (5%)
		LRRCT	355..408	CDD:214507	14/56 (25%)
		Ig	411..500	CDD:472250	20/116 (17%)
		Ig strand B	428..432	CDD:409353	0/3 (0%)
		Ig strand C	441..445	CDD:409353	0/3 (0%)
		Ig strand E	466..470	CDD:409353	1/3 (33%)
		Ig strand F	480..485	CDD:409353	1/4 (25%)
		Ig strand G	493..496	CDD:409353	0/2 (0%)