Protein Alignment kek2 and CHADL

DIOPT Version :10

• Sequence 1: NP_523551.1
• Gene: kek2 / 34582
• FlyBaseID: FBgn0015400
• Length: 894
• Species: Drosophila melanogaster
• Sequence 2: XP_054181131.1
• Gene: CHADL / 150356
• HGNCID: 25165
• Length: 771
• Species: Homo sapiens
• Alignment Length: 393
• Identity: 87/393 - (22%)
• Similarity: 142/393 - (36%)
• Gaps: 133/393 - (33%)

  Fly     4 LPIWIPLLALLAITAA-------CPPEVCVCKWKGGKQTVECGGQQLSNLPEGMDPGTQVLNFSG 61
            :|:.:|||.||.:..|       | |:.|:|  ...::.|.|..|.|:.:|:.:...||.|:..|
Human    10 VPLVLPLLVLLLLAPARQAAAQRC-PQACIC--DNSRRHVACRYQNLTEVPDAIPELTQRLDLQG 71

  Fly    62 NALQVLQSERFLRMDLLNLQKIYLSRNQLIRIHEKAFRGLTNLVELDLSENALQNVPSETFQDYS 126
            |.|:|:.:..|  ..:.:|..:.|...::..:.|.|||||..|:.|:|:.|.|:.:|.|......
Human    72 NLLKVIPAAAF--QGVPHLTHLDLRHCEVELVAEGAFRGLGRLLLLNLASNHLRELPQEALDGLG 134

  Fly   127 SLMRLSLSGNPIRELKTSAFRHLSFLTTLELSNCQVERIENEAFVGMDNLEWLRLDGNRIGFIQG 191
            ||.||.|.||.:.||:...|..|..|.||.|::..:..:...||.|:..:.||||..|.:..
Human   135 SLRRLELEGNALEELRPGTFGALGALATLNLAHNALVYLPAMAFQGLLRVRWLRLSHNALSV--- 196

  Fly   192 THILPKSLHG------ISLHSNR------------------------------------------ 208
              :.|::|.|      :|||.|.
Human   197 --LAPEALAGLPALRRLSLHHNELQALPGPVLSQARGLARLELGHNPLTYAGEEDGLALPGLREL 259

  Fly   209 -----------------------------------------------------WNCDCRLLDIHF 220
                                                                 | |.|:...:..
Human   260 LLDGGALQALGPRAFAHCPRLHTLDLRGNQLDTLPPLQGPGQLRRLRLQGNPLW-CGCQARPLLE 323

  Fly   221 WLVNYNTPLAEEPKCMEPARLKGQVIKSLQREQLACLPEVSPQSSYTEVSEGRNMSITCLVRAIP 285
            ||.  ...:..:..|..|.||:|:.:.:|:...|.|..:.:.:..  |:.|          ||:.
Human   324 WLA--RARVRSDGACQGPRRLRGEALDALRPWDLRCPGDAAQEEE--ELEE----------RAVA 374

  Fly   286 EPK 288
            .|:
Human   375 GPR 377

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kek2	NP_523551.1	LRR	<34..>204	CDD:443914	54/175 (31%)
		leucine-rich repeat	34..52	CDD:275380	5/17 (29%)
		leucine-rich repeat	54..79	CDD:275380	8/24 (33%)
		leucine-rich repeat	80..103	CDD:275380	8/22 (36%)
		leucine-rich repeat	104..127	CDD:275380	7/22 (32%)
		leucine-rich repeat	128..151	CDD:275380	10/22 (45%)
		leucine-rich repeat	152..175	CDD:275380	7/22 (32%)
		leucine-rich repeat	176..198	CDD:275380	6/21 (29%)
		LRRCT	207..256	CDD:214507	13/143 (9%)
		Ig_3	258..348	CDD:464046	5/31 (16%)
CHADL	XP_054181131.1	LRRNT	33..65	CDD:214470	9/34 (26%)
		leucine-rich repeat	44..62	CDD:275380	5/17 (29%)
		leucine-rich repeat	64..87	CDD:275380	8/24 (33%)
		LRR_8	65..146	CDD:404697	29/82 (35%)
		leucine-rich repeat	88..135	CDD:275380	15/46 (33%)
		LRR	<128..>312	CDD:443914	31/188 (16%)
		leucine-rich repeat	136..159	CDD:275380	10/22 (45%)
		leucine-rich repeat	160..183	CDD:275380	7/22 (32%)
		leucine-rich repeat	184..207	CDD:275380	8/27 (30%)
		leucine-rich repeat	208..231	CDD:275380	4/22 (18%)
		leucine-rich repeat	232..255	CDD:275380	0/22 (0%)
		leucine-rich repeat	256..279	CDD:275380	0/22 (0%)
		LRRNT	395..429	CDD:214470
		leucine-rich repeat	410..426	CDD:275380
		leucine-rich repeat	427..450	CDD:275380
		LRR	<445..>677	CDD:443914
		leucine-rich repeat	451..474	CDD:275380
		leucine-rich repeat	475..498	CDD:275380
		leucine-rich repeat	499..522	CDD:275380
		leucine-rich repeat	523..546	CDD:275380
		leucine-rich repeat	547..570	CDD:275380
		leucine-rich repeat	571..594	CDD:275380
		leucine-rich repeat	595..619	CDD:275380
		leucine-rich repeat	620..644	CDD:275380
		LRRCT	675..723	CDD:214507