DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kek2 and Rtn4r

DIOPT Version :9

Sequence 1:	NP_523551.1	Gene:	kek2 / 34582	FlyBaseID:	FBgn0015400	Length:	894	Species:	Drosophila melanogaster
Sequence 2:	NP_446065.1	Gene:	Rtn4r / 113912	RGDID:	620810	Length:	473	Species:	Rattus norvegicus

Alignment Length:	354	Identity:	94/354 - (26%)
Similarity:	132/354 - (37%)	Gaps:	85/354 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SGLPIWIPLLALLAITAACPPEVCVCKWKGGKQTVECGGQQLSNLPEGMDPGTQVLNFSGNALQV 66
            |.||.|:..|....:...| |..||| :...|.|.....|.|..:|.|:...:|.:...||.:..
  Rat     9 SRLPTWVLWLQAWRVATPC-PGACVC-YNEPKVTTSRPQQGLQAVPAGIPASSQRIFLHGNRISY 71

  Fly    67 LQSERFLRMDLLNLQKIYLSRNQLIRIHEKAFRGLTNLVELDLSENA------------------ 113
            :.:..|  ....||..::|..|.|..|...||.|||.|.:||||:||
  Rat    72 VPAASF--QSCRNLTILWLHSNALAGIDAAAFTGLTLLEQLDLSDNAQLRVVDPTTFRGLGHLHT 134

  Fly   114 -------------------------------LQNVPSETFQDYSSLMRLSLSGNPIRELKTSAFR 147
                                           ||.:|..||:|..:|..|.|.||.|..:...|||
  Rat   135 LHLDRCGLQELGPGLFRGLAALQYLYLQDNNLQALPDNTFRDLGNLTHLFLHGNRIPSVPEHAFR 199

  Fly   148 HLSFLTTLELSNCQVERIENEAFVGMDNLEWLRLDGNRIGFIQGTHILP-KSLHGISLHSNRWNC 211
            .|..|..|.|....|.|:...||..:..|..|.|..|.:..:....::| :||..:.|:.|.|.|
  Rat   200 GLHSLDRLLLHQNHVARVHPHAFRDLGRLMTLYLFANNLSMLPAEVLVPLRSLQYLRLNDNPWVC 264

  Fly   212 DCRLLDIHFWLVNYNTPLAEEPKCMEPARLKGQVIKSL------------------QREQL---- 254
            |||...:..||..:....:..|..: |.||.|:.:|.|                  |..||
  Rat   265 DCRARPLWAWLQKFRGSSSGVPSNL-PQRLAGRDLKRLATSDLEGCAVASGPFRPFQTNQLTDEE 328

  Fly   255 ------ACLPEVSPQSSYTEVSEGRNMSI 277
                  .|.|:.:.::|..|  .||..|:
  Rat   329 LLGLPKCCQPDAADKASVLE--PGRPASV 355

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek2	NP_523551.1	leucine-rich repeat	34..52	CDD:275380	5/17 (29%)
		leucine-rich repeat	54..79	CDD:275380	4/24 (17%)
		LRR_8	79..138	CDD:290566	29/107 (27%)
		LRR_RI	<80..187	CDD:238064	44/155 (28%)
		leucine-rich repeat	80..103	CDD:275380	9/22 (41%)
		leucine-rich repeat	104..127	CDD:275380	13/71 (18%)
		LRR_8	126..186	CDD:290566	21/59 (36%)
		leucine-rich repeat	128..151	CDD:275380	10/22 (45%)
		leucine-rich repeat	152..175	CDD:275380	7/22 (32%)
		leucine-rich repeat	176..198	CDD:275380	5/22 (23%)
		TPKR_C2	207..256	CDD:301599	18/76 (24%)
		I-set	258..361	CDD:254352	6/20 (30%)
		Ig_2	263..361	CDD:290606	5/15 (33%)
Rtn4r	NP_446065.1	LRR 1. /evidence=ECO:0000255	56..79		4/24 (17%)
		LRR_8	60..115	CDD:290566	20/56 (36%)
		leucine-rich repeat	60..82	CDD:275380	4/23 (17%)
		LRR 2. /evidence=ECO:0000255	80..103		8/22 (36%)
		LRR_RI	81..>261	CDD:238064	49/179 (27%)
		leucine-rich repeat	83..106	CDD:275380	9/22 (41%)
		LRR 3. /evidence=ECO:0000255	105..128		8/22 (36%)
		leucine-rich repeat	107..131	CDD:275380	7/23 (30%)
		LRR 4. /evidence=ECO:0000255	129..152		0/22 (0%)
		LRR_8	131..190	CDD:290566	11/58 (19%)
		leucine-rich repeat	132..155	CDD:275380	0/22 (0%)
		LRR 5. /evidence=ECO:0000255	153..176		5/22 (23%)
		LRR_4	156..195	CDD:289563	12/38 (32%)
		leucine-rich repeat	156..179	CDD:275380	6/22 (27%)
		LRR 6. /evidence=ECO:0000255	178..200		8/21 (38%)
		LRR_8	179..238	CDD:290566	21/58 (36%)
		leucine-rich repeat	180..203	CDD:275380	10/22 (45%)
		LRR 7. /evidence=ECO:0000255	202..224		7/21 (33%)
		leucine-rich repeat	204..227	CDD:275380	7/22 (32%)
		LRR 8. /evidence=ECO:0000255	225..248		4/22 (18%)
		leucine-rich repeat	228..251	CDD:275380	5/22 (23%)
		LRR 9. /evidence=ECO:0000255	250..273		9/22 (41%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	346..446		4/12 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910