DRSC/TRiP Functional Genomics Resources

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Protein Alignment kek2 and LRRC17

DIOPT Version :9

Sequence 1:NP_523551.1 Gene:kek2 / 34582 FlyBaseID:FBgn0015400 Length:894 Species:Drosophila melanogaster
Sequence 2:NP_001026862.1 Gene:LRRC17 / 10234 HGNCID:16895 Length:441 Species:Homo sapiens


Alignment Length:259 Identity:62/259 - (23%)
Similarity:95/259 - (36%) Gaps:81/259 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    34 QTVECGGQQLSNLPEGMDPGTQVLNFSGNALQVLQSERFLRMDLLNLQKIYLSRNQLIRIHEKAF 98
            ||::|..::|..:|..:.|....|:.|.|.:..|:.:.|  .|:..|:|:.||.|.:..|...||
Human   250 QTLDCKRKELKKVPNNIPPDIVKLDLSYNKINQLRPKEF--EDVHELKKLNLSSNGIEFIDPAAF 312

  Fly    99 RGLTNLVELDLSENALQNVPSETFQDYSSLMRLSLSGNPIRELKTSAFRHLSFLTTLELSNCQVE 163
            .|||:|.|||||.|:|||.      ||..|                  ..|.||..|        
Human   313 LGLTHLEELDLSNNSLQNF------DYGVL------------------EDLYFLKLL-------- 345

  Fly   164 RIENEAFVGMDNLEWLRLDGNRIGFIQGTHILPKSLHGISLHSNRWNCDCRLLDIHFWLVNYNTP 228
                          |||                         .|.|.||..:..:::||.::...
Human   346 --------------WLR-------------------------DNPWRCDYNIHYLYYWLKHHYNV 371

  Fly   229 LAEEPKCMEPARLK----GQVIKSLQRE----QLACLPEVSPQSSYTEVSEGRNMSITCLVRAI 284
            .....:|..|...|    |:.|:|...|    :|...||...|.:..:..|.::...|...:::
Human   372 HFNGLECKTPEEYKGWSVGKYIRSYYEECPKDKLPAYPESFDQDTEDDEWEKKHRDHTAKKQSV 435

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kek2NP_523551.1 leucine-rich repeat 34..52 CDD:275380 5/17 (29%)
leucine-rich repeat 54..79 CDD:275380 6/24 (25%)
LRR_8 79..138 CDD:290566 24/58 (41%)
LRR_RI <80..187 CDD:238064 31/106 (29%)
leucine-rich repeat 80..103 CDD:275380 10/22 (45%)
leucine-rich repeat 104..127 CDD:275380 12/22 (55%)
LRR_8 126..186 CDD:290566 8/59 (14%)
leucine-rich repeat 128..151 CDD:275380 2/22 (9%)
leucine-rich repeat 152..175 CDD:275380 2/22 (9%)
leucine-rich repeat 176..198 CDD:275380 3/21 (14%)
TPKR_C2 207..256 CDD:301599 14/56 (25%)
I-set 258..361 CDD:254352 5/27 (19%)
Ig_2 263..361 CDD:290606 3/22 (14%)
LRRC17NP_001026862.1 leucine-rich repeat 63..81 CDD:275380
LRR 1 82..103
LRR_8 84..141 CDD:290566
leucine-rich repeat 84..106 CDD:275380
LRR_4 105..146 CDD:289563
LRR 2 106..127
leucine-rich repeat 107..130 CDD:275380
LRR 3 130..151
leucine-rich repeat 131..154 CDD:275380
leucine-rich repeat 155..244 CDD:275380
leucine-rich repeat 249..269 CDD:275380 5/18 (28%)
LRR_RI <267..>351 CDD:238064 38/156 (24%)
LRR 4 269..290 5/22 (23%)
leucine-rich repeat 270..293 CDD:275380 6/24 (25%)
LRR_8 272..328 CDD:290566 24/57 (42%)
LRR 5 293..314 8/20 (40%)
LRR_4 294..332 CDD:289563 21/43 (49%)
leucine-rich repeat 294..317 CDD:275380 10/22 (45%)
LRR 6 317..340 13/46 (28%)
leucine-rich repeat 318..341 CDD:275380 14/46 (30%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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