DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek2 and lrrn3a

DIOPT Version :9

Sequence 1:	NP_523551.1	Gene:	kek2 / 34582	FlyBaseID:	FBgn0015400	Length:	894	Species:	Drosophila melanogaster
Sequence 2:	XP_005163128.1	Gene:	lrrn3a / 101887059	ZFINID:	ZDB-GENE-061220-7	Length:	691	Species:	Danio rerio

Alignment Length:	658	Identity:	141/658 - (21%)
Similarity:	223/658 - (33%)	Gaps:	241/658 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSGLPIWIPLLALLAITAACPP--------EVCVCK---W------KGGKQTVECGGQQLSNLPE 48
            |..|...:.|||.||:|.:...        ::|.|:   |      .....||:|....|..|||
Zfish     1 MKDLLFAVCLLAGLALTNSVQASKWSVVCLKLCKCEIRPWFSPLSMYNEAPTVDCNDLGLLTLPE 65

  Fly    49 GMDPGTQVLNFSGNALQVLQSE-----RFLRMDLL------------------------------ 78
            .:...||||....|::..:.|.     ....:||.
Zfish    66 RLPSDTQVLLSQANSIAKIDSPLDYLVNLTEVDLSRNNISSLSDIYIGHIPQLLSLHLEENWLSS 130

  Fly    79 ----------NLQKIYLSRNQLIRIHEKAFRGLTNLVELDLSENALQNVPSETFQDYSSLMRLSL 133
                      |||::|::.|.|..|..:||:||..|:.|.|:.|.|:.:.||.|||.|.|..|.:
Zfish   131 LHDNFLAHFPNLQELYVNHNLLSLISAEAFQGLNKLLRLHLNSNQLRAIRSEWFQDLSQLEILMI 195

  Fly   134 SGNPIRELKTSAFRHLSFLTTLELSNCQVERIENEAFVGMD------------------------ 174
            ..|||..::...|:.|..|.:|.|:...:..|.:.|.||:|
Zfish   196 GENPIARIQNMNFKPLINLRSLVLTRMNLTEIPDSALVGLDKLESVSFYDNMFPKVPQAALRQVR 260

  Fly   175 NLEWLRLDGNRIGFIQ---------------------------GTHILP---------------- 196
            ||::|.|:.|.|..||                           ..|.||
Zfish   261 NLKFLDLNKNPIERIQRGDFVDMIHLKELGINSMPELVSIDSFALHNLPELTKIEATNNPRLSYI 325

  Fly   197 ---------------------KSLHGI-----------SLHSNRWNCDCRLLDIHFWLVNYNTPL 229
                                 ::||.|           |:|||...|||    :..|:...||.:
Zfish   326 HPNAFSQLPRLESLMLNSNALRALHHITVESLPNLQEVSIHSNPIYCDC----VIRWINMNNTRV 386

  Fly   230 ----AEEPKCMEPARLKGQVIKSLQREQLA--CLPEVSPQS--SYTEVSEGRNMSITCLVRAIPE 286
                .:...|..|:..:|:::|.:...::|  |||.:||:|  ....|..|..:|:.|...|.||
Zfish   387 RFMELDALLCAGPSEFEGRLVKQVHSREMADICLPLISPESLPDQVNVGTGHLVSLHCRAFADPE 451

  Fly   287 PKVLWLFNGQVMSNDSL---MDNLHMYYYIDETIGVSGAEEKRSEIFIYNVGAEDNGTFSCVGQN 348
            |::.|:    ..|.:.:   ||:...:.:.:.|..            ||.:...:.|.::||..|
Zfish   452 PEIYWV----TPSGEKILPQMDSKKYHLHPEGTFD------------IYGITENEAGQYTCVAHN 500

  Fly   349 IAGTTFSNYTLRVIIKEPPVVNE---VSFPRDYMNYIVAS--SAGGGIIFVVLLCT--------- 399
            :.|....:..:.|....|.:|||   :.......|.:..|  ...|.::..:...|
Zfish   501 LIGVDMRSVLVIVNGYYPLLVNESLHIQVENTEPNSVSISWVPPKGSLVSNIKWSTNSQHHSLQF 565

  Fly   400 ---IVVKCKK------------------TSEPAKQRKKCDQVTSIAGGTDSSTGSTQDTGMGMMK 443
               :|...||                  |...::..|.|..||:    |:.|.....|
Zfish   566 TSHVVSNVKKFYLTNLHSLTQYEVCVEITDMQSRHLKNCINVTT----TEVSKRKNDD------- 619

  Fly   444 CASILNDG 451
               ::|||
Zfish   620 ---VINDG 624

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek2	NP_523551.1	leucine-rich repeat	34..52	CDD:275380	7/17 (41%)
		leucine-rich repeat	54..79	CDD:275380	8/69 (12%)
		LRR_8	79..138	CDD:290566	25/58 (43%)
		LRR_RI	<80..187	CDD:238064	41/130 (32%)
		leucine-rich repeat	80..103	CDD:275380	10/22 (45%)
		leucine-rich repeat	104..127	CDD:275380	10/22 (45%)
		LRR_8	126..186	CDD:290566	21/83 (25%)
		leucine-rich repeat	128..151	CDD:275380	7/22 (32%)
		leucine-rich repeat	152..175	CDD:275380	8/46 (17%)
		leucine-rich repeat	176..198	CDD:275380	10/85 (12%)
		TPKR_C2	207..256	CDD:301599	12/54 (22%)
		I-set	258..361	CDD:254352	24/107 (22%)
		Ig_2	263..361	CDD:290606	21/102 (21%)
lrrn3a	XP_005163128.1	LRR_RI	29..>272	CDD:238064	60/242 (25%)
		leucine-rich repeat	52..70	CDD:275380	7/17 (41%)
		leucine-rich repeat	71..93	CDD:275380	6/21 (29%)
		leucine-rich repeat	94..117	CDD:275380	2/22 (9%)
		leucine-rich repeat	118..141	CDD:275380	0/22 (0%)
		LRR_8	140..200	CDD:290566	25/59 (42%)
		leucine-rich repeat	142..165	CDD:275380	10/22 (45%)
		leucine-rich repeat	166..189	CDD:275380	10/22 (45%)
		leucine-rich repeat	190..213	CDD:275380	7/22 (32%)
		LRR_8	213..272	CDD:290566	13/58 (22%)
		leucine-rich repeat	214..237	CDD:275380	7/22 (32%)
		leucine-rich repeat	238..261	CDD:275380	0/22 (0%)
		leucine-rich repeat	262..285	CDD:275380	7/22 (32%)
		leucine-rich repeat	286..310	CDD:275380	2/23 (9%)
		LRR_8	309..370	CDD:290566	8/60 (13%)
		leucine-rich repeat	311..333	CDD:275380	0/21 (0%)
		leucine-rich repeat	336..359	CDD:275378	3/22 (14%)
		leucine-rich repeat	360..372	CDD:275378	4/11 (36%)
		LRRCT	368..412	CDD:214507	11/47 (23%)
		IG_like	429..513	CDD:214653	20/99 (20%)
		Ig	437..513	CDD:299845	19/91 (21%)
		FN3	526..>591	CDD:238020	7/64 (11%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm6470
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.000