Protein Alignment kek2 and mxra5a

DIOPT Version :10

• Sequence 1: NP_523551.1
• Gene: kek2 / 34582
• FlyBaseID: FBgn0015400
• Length: 894
• Species: Drosophila melanogaster
• Sequence 2: XP_001919144.4
• Gene: mxra5a / 100151112
• ZFINID: ZDB-GENE-090312-22
• Length: 2516
• Species: Danio rerio
• Alignment Length: 1018
• Identity: 205/1018 - (20%)
• Similarity: 331/1018 - (32%)
• Gaps: 334/1018 - (32%)

  Fly     6 IWIPLLALLAITAA--CPPEVCVCKWKGGKQTVE--CGGQQLSNLPEGMDPGTQVLNFSGNALQV 66
            ||| :|.|:|:..|  |.|..|.|     .|.||  |..:.|..:|.|:....:.:|
Zfish     8 IWI-MLMLIAVPVAVQCCPRPCAC-----HQPVEVHCTFRSLLTVPAGVPKQVERMN-------- 58

  Fly    67 LQSERFLRMDLLNLQKIYLSRNQLIRIHEKAFRGLTNLVELDLSENALQNVPSETFQDYSSLMRL 131
                              |..|.:.:|...:|.||..:..|.:..|.:..:|..||:|..||..|
Zfish    59 ------------------LGFNTIHKITYSSFAGLRKMELLLMHGNNVHQIPDGTFRDLISLQML 105

  Fly   132 SLSGNPIRELKTSAFRHLSFLTTLELSNCQVERIENEAFVGMDNLEWLRLDGNRIGFIQGTH--- 193
            .||.|.::.|.......|..||.|.|.:.::|.|..:||.|:.||..|.|:||:   :|..|
Zfish   106 KLSYNKLKLLSRQTLMGLWSLTRLHLDHNRLEFIHPDAFQGLTNLRLLHLEGNQ---LQQLHPAT 167

  Fly   194 -----IL---PKS-------------------------LHGISLHSNRWNCDCRLLDIHFWLVNY 225
                 :|   |.|                         |..:|||.|.|.||||:...:.|..|.
Zfish   168 FSTFSVLRHFPVSTLKHLYLSDNILTTLSQKMLASMPYLESLSLHGNPWTCDCRMRWFNEWNKNS 232

  Fly   226 NTPLAEE-----------PKCMEPARLKGQVIKSLQREQLAC---LPEVSPQSSYTEVSE----- 271
            ...|..:           |.|..|.:||.:.::.|  |:..|   :..:|.::..:|.:|
Zfish   233 QGVLKCKKDKAYPSGQLCPLCFSPKQLKKKQLQEL--EKPTCNSPIISISNRAISSEDTESDLLT 295

  Fly   272 -------------------GRNMSITCLVRAIPEPKVL----WLFNGQVMSNDSLMDNLHMYYYI 313
                               |..:.:.|||   .||:.|    |.:..|...:.:|...|.:...|
Zfish   296 MDEFRQPLGNISLGLSDEHGHQVDLECLV---IEPRELTSIGWDYVNQYQISVNLTLTLDLICGI 357

  Fly   314 DETIGVSGAEEK---------------RSEIFI---------YNVGAE-DNGTFSCVGQNIAGTT 353
            |.:     :.|:               |.||.:         |....| |...|:.|..|||.
Zfish   358 DRS-----SYERLWRLIAYYSDVPAHLRREIMLSKDPYLSYRYRQDIERDALYFTGVKANIAA-- 415

  Fly   354 FSNYTLRVIIKEPPVVNEVSFPRDYMNYIVASSAGGGIIFVVLLCTIVVKCKKTSEPAKQRKKCD 418
                       .||.:.:.|.... :|.:.::|....:|....:..::       |....||:..
Zfish   416 -----------NPPWLMQSSMDLQ-LNRLQSTSKNVRLILSTYMTDVM-------ERETIRKQSQ 461

  Fly   419 QVTSIAGGTDSSTGSTQDTGMGMMKCASILNDGGDSMNGNPGLLLGDTL-TPTKAAN---GAAGG 479
            ....|....|:.|......|.......::.:.|.:|:...  |..|.|: ||.:.:.   .|:..
Zfish   462 GWVLIESKNDTRTMQAAVVGSPAKINCTVHSSGNESVKWM--LPDGSTIETPYRNSENRLSASSS 524

  Fly   480 GIILGNQMK-----QNLLLYATPNSAQQQLQLNVNLMGTGPGSPPLLLSNGHGL---AAAYCSPP 536
            |::   ::|     .:.:.|.....:.........|......|||   ..|.|:   ...:...|
Zfish   525 GLL---EIKSLDHSDSGVYYCIAQVSDDLTVFPFRLTVEESSSPP---PGGEGITEPVTGFAGEP 583

  Fly   537 ASLRNYQEKNPD------LVNDAESVKHKLKTAVSLDGAGEYETQSDCGQYEGCYQLAAAPHPHQ 595
            .||......:||      |.|.:...|....:.:|:...|....|:......|.|:..|
Zfish   584 FSLPCAATGSPDADIHWILPNGSIVNKWLNISRISVASNGSLVIQNSQLSDNGYYKCVA------ 642

  Fly   596 GHQH-------------PHPGHPLMGRFAQAMTTLPRGMQLKPAPHQ-VDVHLN----------- 635
            |:||             | ||.|.:.:::.:           |.|.: |...:|
Zfish   643 GNQHGMDTLATKLIISRP-PGIPALRKYSSS-----------PQPAEGVSTKINILMTNDMESSG 695

  Fly   636 ---PVCFLGQDGSFAYDYSSAHMVQQPPQQQQQQQQVQPANNFYRTLPHNRLHKQQQFQAAAAAG 697
               |..||.:        :.|..|:.|.:               |.:|
Zfish   696 DNEPEDFLAK--------ALAKKVEIPNR---------------RRIP----------------- 720

  Fly   698 GNVGV-GGNP---------TLRYSLEAEFIQRGPTV------SYEKYQLP--------------- 731
             |:|: ||:|         |.|..:..:.|.|..||      |..|.|:.
Zfish   721 -NMGIRGGHPSRNSWRQASTPRRRVGTQVIDRANTVDSRRRISMLKNQIDPKHWASILSKVRSGG 784

  Fly   732 -NVRFTAEGYPQQQQQQQQQLQQQQQLQLQQQHQFPSPPEGYKSDLAVMPAPFQQWPSCLPGYRF 795
             :.:.|...|.|....:.|:.:|.     .:|.:..:..||..|:......|.:.
Zfish   785 NDTKATTPNYAQTSTNKIQESEQN-----TKQSEIVNKIEGSSSEFTTTRPPVKD---------- 834

  Fly   796 AQSPTSLPAVATPPPAAVVATPPPPTSAVSTQSTATSTIPELD 838
             .:.:.:|..||.....:.|.....|..|..|..:..|:|..|
Zfish   835 -ATVSQMPDGATEFNLDIRALDYENTRHVIYQIASPETVPNSD 876

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kek2	NP_523551.1	LRR	<34..>204	CDD:443914	49/207 (24%)
		leucine-rich repeat	34..52	CDD:275380	7/19 (37%)
		leucine-rich repeat	54..79	CDD:275380	1/24 (4%)
		leucine-rich repeat	80..103	CDD:275380	6/22 (27%)
		leucine-rich repeat	104..127	CDD:275380	6/22 (27%)
		leucine-rich repeat	128..151	CDD:275380	7/22 (32%)
		leucine-rich repeat	152..175	CDD:275380	9/22 (41%)
		leucine-rich repeat	176..198	CDD:275380	9/32 (28%)
		LRRCT	207..256	CDD:214507	16/59 (27%)
		Ig_3	258..348	CDD:464046	25/142 (18%)
mxra5a	XP_001919144.4	None