Protein Alignment kek2 and islr2

DIOPT Version :10

• Sequence 1: NP_523551.1
• Gene: kek2 / 34582
• FlyBaseID: FBgn0015400
• Length: 894
• Species: Drosophila melanogaster
• Sequence 2: NP_001120371.1
• Gene: islr2 / 100145445
• XenbaseID: XB-GENE-5920691
• Length: 691
• Species: Xenopus tropicalis
• Alignment Length: 689
• Identity: 150/689 - (21%)
• Similarity: 253/689 - (36%)
• Gaps: 186/689 - (26%)

  Fly    12 ALLAITAACPPEVCVCKWKGGKQTVECGGQQLSNLPEGMDPGTQVLNFSGNALQVLQSERFLRMD 76
            |||.:|..| ||.|.|..|..:|..:|..::|..:|.|.......|:.|.|.:..|:...|:.:.
 Frog    12 ALLGLTLGC-PEPCSCVDKYNQQFADCTYKKLQKIPSGFPSNVTTLSLSANKITSLKKSDFIGVP 75

  Fly    77 LLNLQKIYLSRNQLIRIHEKAFRGLTNLVELDLSENALQNVPSETFQDYSSLMRLSLSGNPIREL 141
              .:..::|:.|::..|.|.|...:.||..||:|.|.|...|   ::|.:||..|.|
 Frog    76 --QVTSLWLAHNEISEIEEGALATMVNLKNLDVSHNLLVEFP---WRDLASLSALQL-------- 127

  Fly   142 KTSAFRHLSFLTTLELSNCQVERIENEAFVGMDNLEWLRLDGNRIGFIQ-GTHILPKSLHGISLH 205
                         ::::|.::..:..:||..::.|:.||::.|:...|| ||.....||..|.::
 Frog   128 -------------IKMNNNRMVNLPRDAFQNLNELKSLRINNNQFSVIQEGTFKPLISLSHIQIY 179

  Fly   206 SNRWNCDCRLLDIHFWL--VNYNTPLAEEPKCMEPARLKGQVIKSLQREQLAC-LPEVS----PQ 263
            :|.::|.|.|:.:..|.  ..::.|..:...|..|..|||..|..:  ..|.| .|.|.    |.
 Frog   180 NNPFHCSCSLMWLKKWAEEAQFSVPEKDNIACSSPEELKGTPISKI--PDLPCEAPTVQLSYYPN 242

  Fly   264 SSYTEVSEGRNMSITCLVRAIPEPKVLWLFNGQVMSNDSLMDNLHMYYYIDETIGVSGAEEKRSE 328
            ...||:.:|..:|:.||...||:|.:.|.........:       :...:|..:..|...:|.|.
 Frog   243 LDSTELYDGFTLSLQCLASGIPQPTIKWKVRNATQETE-------IKQPVDGQVKGSAKSQKSSS 300

  Fly   329 IFIYNVGA--------EDNGTFSCVGQNIAGTTFSNYTLRV---------IIKEPPVVNEVSFPR 376
            ..::..|.        :..||:.|.|.|..|::.::..:.|         :|:||  ....|.|.
 Frog   301 FLVFQNGTLVIPHLSKKMEGTYICEGNNEMGSSQASVNVSVAGSQKYPTKVIEEP--TKSKSLPE 363

  Fly   377 DYMNYIVASSAGGGIIFVVLLCTIVVKCKKTSEPAKQRKKCDQVTSIAGG-------TDSSTGST 434
            :....:..|..|..          |:|..|:.|..|.....:|.....|.       ||..:.|.
 Frog   364 NKKPGVKTSDTGNS----------VIKPDKSEEKGKPLIPTEQPFMTGGNKLGVPEHTDHPSASD 418

  Fly   435 QDTGMGMMKCASILNDGG---------DSMNGNP-----GLLLGDT--------LTP--TKAAN- 474
            :       ||..  :.||         :|.|..|     |::..|.        :||  .:..|
 Frog   419 K-------KCGP--STGGQHISNHAFNESTNLKPHTFELGVIALDVSEKDAKVQITPYHNRQGND 474

  Fly   475 ----------GAAGGGIILGNQMKQNLLLY--------------ATPNSAQQQLQ---------- 505
                      ||.|..::..::::..:..|              .|......|:|
 Frog   475 HLRMLYLCQEGANGLSLVQWSEIEDRVNSYWFQGLIPGTNYSVCLTYKGEDCQVQVVFTTKKEVP 539

  Fly   506 -----LNVNLMGTGPGSPPL-------LLSNGHG------------------LAAAYCSPPASL- 539
                 :.|::...|..:.||       |||..||                  :||.: .|.||.
 Frog   540 SLIIIIVVSIFLLGLATIPLMGATCCHLLSKYHGKNYKLIMKAQKSDPMEKQMAADF-DPRASFV 603

  Fly   540 ---RNYQEKNPDLVNDAESVKHKLKTAVSLDGAGEYETQ 575
               :|:   ||..:.|.|:....:......:|.||.|.:
 Frog   604 ESEKNF---NPSEMGDVEAEGDSVPIGGEGEGEGEAEVE 639

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kek2	NP_523551.1	LRR	<34..>204	CDD:443914	42/170 (25%)
		leucine-rich repeat	34..52	CDD:275380	5/17 (29%)
		leucine-rich repeat	54..79	CDD:275380	5/24 (21%)
		leucine-rich repeat	80..103	CDD:275380	5/22 (23%)
		leucine-rich repeat	104..127	CDD:275380	8/22 (36%)
		leucine-rich repeat	128..151	CDD:275380	3/22 (14%)
		leucine-rich repeat	152..175	CDD:275380	3/22 (14%)
		leucine-rich repeat	176..198	CDD:275380	8/22 (36%)
		LRRCT	207..256	CDD:214507	13/50 (26%)
		Ig_3	258..348	CDD:464046	22/101 (22%)
islr2	NP_001120371.1	LRR	<36..>228	CDD:443914	53/219 (24%)
		leucine-rich repeat	36..52	CDD:275380	4/15 (27%)
		leucine-rich repeat	53..76	CDD:275380	5/24 (21%)
		leucine-rich repeat	77..100	CDD:275380	5/22 (23%)
		leucine-rich repeat	101..124	CDD:275380	10/25 (40%)
		leucine-rich repeat	125..148	CDD:275380	5/43 (12%)
		leucine-rich repeat	149..172	CDD:275380	8/22 (36%)
		Ig	251..332	CDD:472250	18/87 (21%)
		Ig strand B	254..258	CDD:409353	1/3 (33%)
		Ig strand C	267..271	CDD:409353	0/3 (0%)
		Ig strand E	307..311	CDD:409353	1/3 (33%)
		Ig strand F	321..326	CDD:409353	2/4 (50%)