DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek2 and islr2

DIOPT Version :9

Sequence 1:	NP_523551.1	Gene:	kek2 / 34582	FlyBaseID:	FBgn0015400	Length:	894	Species:	Drosophila melanogaster
Sequence 2:	NP_001120371.1	Gene:	islr2 / 100145445	XenbaseID:	XB-GENE-5920691	Length:	691	Species:	Xenopus tropicalis

Alignment Length:	689	Identity:	150/689 - (21%)
Similarity:	253/689 - (36%)	Gaps:	186/689 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 ALLAITAACPPEVCVCKWKGGKQTVECGGQQLSNLPEGMDPGTQVLNFSGNALQVLQSERFLRMD 76
            |||.:|..| ||.|.|..|..:|..:|..::|..:|.|.......|:.|.|.:..|:...|:.:.
Frog    12 ALLGLTLGC-PEPCSCVDKYNQQFADCTYKKLQKIPSGFPSNVTTLSLSANKITSLKKSDFIGVP 75

  Fly    77 LLNLQKIYLSRNQLIRIHEKAFRGLTNLVELDLSENALQNVPSETFQDYSSLMRLSLSGNPIREL 141
              .:..::|:.|::..|.|.|...:.||..||:|.|.|...|   ::|.:||..|.|
Frog    76 --QVTSLWLAHNEISEIEEGALATMVNLKNLDVSHNLLVEFP---WRDLASLSALQL-------- 127

  Fly   142 KTSAFRHLSFLTTLELSNCQVERIENEAFVGMDNLEWLRLDGNRIGFIQ-GTHILPKSLHGISLH 205
                         ::::|.::..:..:||..::.|:.||::.|:...|| ||.....||..|.::
Frog   128 -------------IKMNNNRMVNLPRDAFQNLNELKSLRINNNQFSVIQEGTFKPLISLSHIQIY 179

  Fly   206 SNRWNCDCRLLDIHFWL--VNYNTPLAEEPKCMEPARLKGQVIKSLQREQLAC-LPEVS----PQ 263
            :|.::|.|.|:.:..|.  ..::.|..:...|..|..|||..|..:  ..|.| .|.|.    |.
Frog   180 NNPFHCSCSLMWLKKWAEEAQFSVPEKDNIACSSPEELKGTPISKI--PDLPCEAPTVQLSYYPN 242

  Fly   264 SSYTEVSEGRNMSITCLVRAIPEPKVLWLFNGQVMSNDSLMDNLHMYYYIDETIGVSGAEEKRSE 328
            ...||:.:|..:|:.||...||:|.:.|.........:       :...:|..:..|...:|.|.
Frog   243 LDSTELYDGFTLSLQCLASGIPQPTIKWKVRNATQETE-------IKQPVDGQVKGSAKSQKSSS 300

  Fly   329 IFIYNVGA--------EDNGTFSCVGQNIAGTTFSNYTLRV---------IIKEPPVVNEVSFPR 376
            ..::..|.        :..||:.|.|.|..|::.::..:.|         :|:||  ....|.|.
Frog   301 FLVFQNGTLVIPHLSKKMEGTYICEGNNEMGSSQASVNVSVAGSQKYPTKVIEEP--TKSKSLPE 363

  Fly   377 DYMNYIVASSAGGGIIFVVLLCTIVVKCKKTSEPAKQRKKCDQVTSIAGG-------TDSSTGST 434
            :....:..|..|..          |:|..|:.|..|.....:|.....|.       ||..:.|.
Frog   364 NKKPGVKTSDTGNS----------VIKPDKSEEKGKPLIPTEQPFMTGGNKLGVPEHTDHPSASD 418

  Fly   435 QDTGMGMMKCASILNDGG---------DSMNGNP-----GLLLGDT--------LTP--TKAAN- 474
            :       ||..  :.||         :|.|..|     |::..|.        :||  .:..|
Frog   419 K-------KCGP--STGGQHISNHAFNESTNLKPHTFELGVIALDVSEKDAKVQITPYHNRQGND 474

  Fly   475 ----------GAAGGGIILGNQMKQNLLLY--------------ATPNSAQQQLQ---------- 505
                      ||.|..::..::::..:..|              .|......|:|
Frog   475 HLRMLYLCQEGANGLSLVQWSEIEDRVNSYWFQGLIPGTNYSVCLTYKGEDCQVQVVFTTKKEVP 539

  Fly   506 -----LNVNLMGTGPGSPPL-------LLSNGHG------------------LAAAYCSPPASL- 539
                 :.|::...|..:.||       |||..||                  :||.: .|.||.
Frog   540 SLIIIIVVSIFLLGLATIPLMGATCCHLLSKYHGKNYKLIMKAQKSDPMEKQMAADF-DPRASFV 603

  Fly   540 ---RNYQEKNPDLVNDAESVKHKLKTAVSLDGAGEYETQ 575
               :|:   ||..:.|.|:....:......:|.||.|.:
Frog   604 ESEKNF---NPSEMGDVEAEGDSVPIGGEGEGEGEAEVE 639

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek2	NP_523551.1	leucine-rich repeat	34..52	CDD:275380	5/17 (29%)
		leucine-rich repeat	54..79	CDD:275380	5/24 (21%)
		LRR_8	79..138	CDD:290566	18/58 (31%)
		LRR_RI	<80..187	CDD:238064	25/106 (24%)
		leucine-rich repeat	80..103	CDD:275380	5/22 (23%)
		leucine-rich repeat	104..127	CDD:275380	8/22 (36%)
		LRR_8	126..186	CDD:290566	11/59 (19%)
		leucine-rich repeat	128..151	CDD:275380	3/22 (14%)
		leucine-rich repeat	152..175	CDD:275380	3/22 (14%)
		leucine-rich repeat	176..198	CDD:275380	8/22 (36%)
		TPKR_C2	207..256	CDD:301599	13/50 (26%)
		I-set	258..361	CDD:254352	24/114 (21%)
		Ig_2	263..361	CDD:290606	21/105 (20%)
islr2	NP_001120371.1	leucine-rich repeat	36..52	CDD:275380	4/15 (27%)
		LRR_8	51..111	CDD:290566	16/61 (26%)
		LRR_4	52..92	CDD:289563	8/41 (20%)
		leucine-rich repeat	53..76	CDD:275380	5/24 (21%)
		LRR_4	75..115	CDD:289563	12/41 (29%)
		leucine-rich repeat	77..100	CDD:275380	5/22 (23%)
		LRR_8	100..159	CDD:290566	20/82 (24%)
		leucine-rich repeat	101..124	CDD:275380	10/25 (40%)
		leucine-rich repeat	125..148	CDD:275380	5/43 (12%)
		leucine-rich repeat	149..172	CDD:275380	8/22 (36%)
		LRRCT	181..>219	CDD:214507	9/37 (24%)
		IG_like	251..341	CDD:214653	19/96 (20%)
		Ig	254..338	CDD:143165	18/90 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm9487
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000