DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek2 and lrfn5a

DIOPT Version :9

Sequence 1:	NP_523551.1	Gene:	kek2 / 34582	FlyBaseID:	FBgn0015400	Length:	894	Species:	Drosophila melanogaster
Sequence 2:	XP_001921674.1	Gene:	lrfn5a / 100144400	ZFINID:	ZDB-GENE-080327-17	Length:	786	Species:	Danio rerio

Alignment Length:	637	Identity:	148/637 - (23%)
Similarity:	228/637 - (35%)	Gaps:	195/637 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 LAITAACPPEVCVCKWKGGKQTVECGGQQLSNLPEGMDPGTQVLNFSGNALQVLQSERFLRMDLL 78
            :|:.|...|:.|||:.........|..:.|..:|..:|..|..|..:.|.:..::     |.||.
Zfish    13 MAVKAQICPKRCVCQVLSPNLATLCAKKGLLFVPPNIDRHTVELRLADNFVTSVK-----RKDLA 72

  Fly    79 NLQKIY---LSRNQLIRIHEKAFRGLTNLVELDLSENALQNVPSETFQDYSSLMRLSLSGNPIRE 140
            |:.|:.   ||||.:..|...||..|.||..|.|..|.|..:.::||...|.|..|.|:.|.:..
Zfish    73 NMTKLVDLTLSRNTISYITPHAFADLENLRALHLDHNRLTRIANDTFSGMSKLHHLILNNNQLTL 137

  Fly   141 LKTSAFRHLSFLTTLELSNCQVERIENEAFVGMDNLEWLRLDGNRIGFI-QGTHILPKSLHGISL 204
            :...||..|..|..|:||...:|.|..||...|.:|..|.||.|.|.:| :||..|.:.|:.:.:
Zfish   138 IHMGAFNDLLALEELDLSYNNLETIPWEAIQRMTSLHTLSLDHNMIEYIPEGTFSLLQKLNRLDV 202

  Fly   205 HSNR-----------------------------------WNCDCRLLDIHFWLVNYNTPLAEEPK 234
            .||:                                   .:|:|.||    ||...|.. .:...
Zfish   203 TSNKLQKLPPDPLFQRAQVLATSGIMNPSSFALSFGGNPLHCNCELL----WLRRLNRE-DDLET 262

  Fly   235 CMEPARLKGQVIKSLQREQLACLPEVSPQSSY-TEVSEGRNMSITCLVRAIPEPKVLWLF-NGQV 297
            |..|..|.|:...|:..|:..|.|.:..:.|: ..|.||:.:::.|..|..|||.:.|:. .|::
Zfish   263 CATPLHLSGRYFWSIPEEEFLCEPPLITRHSHEMRVLEGQRVALKCKARGDPEPAIHWISPEGKL 327

  Fly   298 MSNDSLMDNLHMYYYIDETIGVSGAEEKRSEIFIYNVG--------AEDNGTFSCVGQNIAGTTF 354
            :||                         .|...:||.|        .:|.|:|:|:..|.||...
Zfish   328 VSN-------------------------TSRTLVYNNGTLDILISTVKDTGSFTCISSNPAGEAH 367

  Fly   355 SNYTLRVIIKEPPVVNEVSFPRDYMNYIVASSAGGGIIFVVLLCTIVVKCKKTSEPAKQRKKCDQ 419
            ....| ||||.|.:.|
Zfish   368 QTIEL-VIIKLPHISN------------------------------------------------- 382

  Fly   420 VTSIAGGTDSSTGSTQDTGMGMMKCASILNDGGDSMNGNPGLLLGDTLTPTKA-ANGAAGGGIIL 483
                      ||.:.|:.            |.|.|          |..|.|:| |||....|...
Zfish   383 ----------STNNIQEP------------DPGSS----------DISTSTRAGANGGNHTGDTK 415

  Fly   484 GNQMKQNLLLYATPNSAQQQLQLNVNLMGTGPGSPPLLLS-NG-HGLAAAYCSPPASLRNYQEKN 546
            .:..|:.::..||.::|..:.....|:    ||.....:. || :..:..|...|.:.:|:
Zfish   416 TSSDKRVVMAEATSSTALIKFNFQRNI----PGIRMFQIQYNGTYDDSLVYRMIPPTSKNF---- 472

  Fly   547 PDLVND-AESVKHKL------------KTAVSLDGAGEYETQSDCGQYEGCY 585
              |||: |...::.|            .||..:.|..::.|:|   :|..|:
Zfish   473 --LVNNLAAGTQYDLCVLAIYDDGMTSLTATRVVGCVQFTTES---EYLRCH 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek2	NP_523551.1	leucine-rich repeat	34..52	CDD:275380	3/17 (18%)
		leucine-rich repeat	54..79	CDD:275380	6/24 (25%)
		LRR_8	79..138	CDD:290566	23/61 (38%)
		LRR_RI	<80..187	CDD:238064	39/109 (36%)
		leucine-rich repeat	80..103	CDD:275380	9/25 (36%)
		leucine-rich repeat	104..127	CDD:275380	7/22 (32%)
		LRR_8	126..186	CDD:290566	22/59 (37%)
		leucine-rich repeat	128..151	CDD:275380	7/22 (32%)
		leucine-rich repeat	152..175	CDD:275380	9/22 (41%)
		leucine-rich repeat	176..198	CDD:275380	10/22 (45%)
		TPKR_C2	207..256	CDD:301599	14/83 (17%)
		I-set	258..361	CDD:254352	26/112 (23%)
		Ig_2	263..361	CDD:290606	25/107 (23%)
lrfn5a	XP_001921674.1	leucine-rich repeat	53..76	CDD:275380	7/27 (26%)
		LRR_8	75..135	CDD:290566	22/59 (37%)
		leucine-rich repeat	77..100	CDD:275380	8/22 (36%)
		LRR_4	99..138	CDD:289563	13/38 (34%)
		leucine-rich repeat	101..124	CDD:275380	7/22 (32%)
		leucine-rich repeat	125..148	CDD:275380	7/22 (32%)
		leucine-rich repeat	149..172	CDD:275380	9/22 (41%)
		LRR_8	155..207	CDD:290566	19/51 (37%)
		LRR_4	171..212	CDD:289563	13/40 (33%)
		leucine-rich repeat	173..196	CDD:275380	10/22 (45%)
		leucine-rich repeat	197..215	CDD:275380	3/17 (18%)
		TPKR_C2	240..>272	CDD:301599	10/36 (28%)
		I-set	287..374	CDD:254352	25/112 (22%)
		Ig_2	301..374	CDD:143241	22/98 (22%)
		fn3	421..494	CDD:278470	16/82 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm6336
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910