DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek2 and slitrk3

DIOPT Version :9

Sequence 1:	NP_523551.1	Gene:	kek2 / 34582	FlyBaseID:	FBgn0015400	Length:	894	Species:	Drosophila melanogaster
Sequence 2:	XP_002933279.1	Gene:	slitrk3 / 100127669	XenbaseID:	XB-GENE-964617	Length:	885	Species:	Xenopus tropicalis

Alignment Length:	349	Identity:	94/349 - (26%)
Similarity:	151/349 - (43%)	Gaps:	51/349 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSGLPIWIPLLALLAITAACP------------P--EVCVCKWKGGKQTVECGGQQLSNLPEGMD 51
            :.|..:||.||:.:|:....|            |  :.|.|:.|.....:.|..:..:|:.:..:
Frog    10 LKGRMLWIILLSTIALAWTTPIPLIEDSEEIDEPCFDPCYCEVKESLFHIYCDNKGFTNISQITE 74

  Fly    52 PGTQ--VLNFSGNALQVLQSERFLRMDLLNLQKIYLSRNQLIRIHEKAFRGLTNLVELDLSENAL 114
            ..::  .|....|:::.|.:..||.::  |...|.:..|.|..|...||.||..|..|.|.||.|
Frog    75 YWSRPFKLYLQRNSMRKLYTNSFLHLN--NAVSINMGNNALQDIQAGAFNGLKVLKRLYLHENKL 137

  Fly   115 QNVPSETFQDYSSLMRLSLSGNPIRELKTSAFRHLSFLTTLELSNCQVERIENEAFVGMDNLEWL 179
            .:..::||....||..|....|.|:.:::.|||:|:.|..|.|::..:..:....|..: :|..|
Frog   138 DSFKNDTFLGLESLEYLQADYNVIKRIESGAFRYLNKLRVLILNDNHIPLLPTNLFKSV-SLTHL 201

  Fly   180 RLDGNR--IGFIQG--THILPKSLHGISLHSNRWNCDCRLLDIHFWL--VNYNTPLAEEPKCMEP 238
            .|.|||  |.|.:|  .|| .:||..|.|..|.|||.|.:|.:..||  :.| |.|..:..|..|
Frog   202 DLRGNRLKILFYKGMLDHI-GRSLMEIQLAENPWNCTCEILQLKNWLERIPY-TVLVGDITCESP 264

  Fly   239 ARLKGQVIKSLQREQLACLPEVSPQSSYTEVSEGRNMSITCLVRAIPEPKVLWLFNGQVMSNDSL 303
            ....|:.::.::|.:|.  |.::  .|..|:|.|        :..||..|.    |.......|:
Frog   265 FHFHGKDLRDIKRSKLC--PSLT--ESEAEISWG--------IPQIPSSKE----NAWPTKPSSM 313

  Fly   304 MDNLHMYYYIDETIGVSGAEEKRS 327
            :.:.|        :..|..|.|.|
Frog   314 LSSSH--------VTASSVEYKSS 329

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek2	NP_523551.1	leucine-rich repeat	34..52	CDD:275380	2/17 (12%)
		leucine-rich repeat	54..79	CDD:275380	5/26 (19%)
		LRR_8	79..138	CDD:290566	21/58 (36%)
		LRR_RI	<80..187	CDD:238064	35/108 (32%)
		leucine-rich repeat	80..103	CDD:275380	8/22 (36%)
		leucine-rich repeat	104..127	CDD:275380	8/22 (36%)
		LRR_8	126..186	CDD:290566	19/61 (31%)
		leucine-rich repeat	128..151	CDD:275380	8/22 (36%)
		leucine-rich repeat	152..175	CDD:275380	4/22 (18%)
		leucine-rich repeat	176..198	CDD:275380	11/25 (44%)
		TPKR_C2	207..256	CDD:301599	16/50 (32%)
		I-set	258..361	CDD:254352	15/70 (21%)
		Ig_2	263..361	CDD:290606	14/65 (22%)
slitrk3	XP_002933279.1	LRR_8	81..137	CDD:338972	19/57 (33%)
		leucine-rich repeat	81..102	CDD:275380	5/22 (23%)
		leucine-rich repeat	103..126	CDD:275380	8/22 (36%)
		LRR_8	127..185	CDD:338972	20/57 (35%)
		leucine-rich repeat	127..150	CDD:275380	8/22 (36%)
		leucine-rich repeat	151..174	CDD:275380	8/22 (36%)
		leucine-rich repeat	175..197	CDD:275380	4/22 (18%)
		leucine-rich repeat	198..283	CDD:275380	31/88 (35%)
		leucine-rich repeat	224..236	CDD:275378	5/11 (45%)
		LRRCT	232..>270	CDD:214507	13/38 (34%)
		LRR	<388..>562	CDD:227223
		leucine-rich repeat	389..409	CDD:275380
		leucine-rich repeat	410..433	CDD:275380
		leucine-rich repeat	434..457	CDD:275380
		LRR_8	457..516	CDD:338972
		leucine-rich repeat	458..481	CDD:275380
		leucine-rich repeat	482..505	CDD:275380
		leucine-rich repeat	506..528	CDD:275380
		leucine-rich repeat	529..553	CDD:275380
		LRRCT	562..>597	CDD:214507
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910